Q68Y08 (HTPG_RICTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chaperone protein HtpG

Alternative name(s):
Heat shock protein HtpG
High temperature protein G

Gene names

Name:	htpG
Ordered Locus Names:	RT0828

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia typhi

Protein attributes

Sequence length	621 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Molecular chaperone. Has ATPase activity By similarity. HAMAP-Rule MF_00505
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the heat shock protein 90 family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: HAMAP response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 621	621	Chaperone protein HtpG HAMAP-Rule MF_00505		PRO_0000224228
Regions
	Region	1 – 328	328	A; substrate-binding By similarity
	Region	329 – 544	216	B By similarity
	Region	545 – 621	77	C By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q68Y08 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: FC334AD04A502ECB	FASTA	621	70,937
	10 20 30 40 50 60 MTQEKKKFDA EVGKILNLMI HSLYSNKEIF MRELISNASD ACDKLRYLSQ SNSELISGDS 70 80 90 100 110 120 NFKIIVKVDK DNEQIIIRDN GIGMNKEDLI ENLGTIARSG TANFLKNLSG DSKKDNMLIG 130 140 150 160 170 180 QFGVGFYSSF MVADKVTVTS RKAGENKVYT WESDGLGEYI VADSEQEFAR GTEIVLYIKK 190 200 210 220 230 240 AETTFLDHFR LKHIVKSYSD HIAVPIYFCD EASNNEIQLN SASALWTRPK SEITEEQYKE 250 260 270 280 290 300 FYKSLSYSVD DPWVTLHNKN EGAIEFTNLL FIPSSKTFDL FHPDRKRRVK LYIKRVFISD 310 320 330 340 350 360 ENIDLIPSYL RFLRGVVDSE DLPLNISRES LQHNNVLEKI KNAITKRVLG ELRKKKEELP 370 380 390 400 410 420 EEYNKFWTNF GGALKEGLCE ATTDHEKLLE VCIFRSALHN KMISIDEYIA NFKEGQNTIY 430 440 450 460 470 480 YLSGDNPDKL LSSPQIEGLL NKNIDVLLFT DTVDDFWVNV NSEYKGYAIK SATRSDIDVE 490 500 510 520 530 540 HTTSRPQDKN TDSKKSDDEY KLLTDYFKEI LGELVKEVKI SKKLTLSPAC LAVSDTAMDI 550 560 570 580 590 600 RMERFLIEQK QIASASAKNL ELNPKNKIIE KIFNDLKANN KNNEELVNLI FDQACILEGE 610 620 PIADTGAFSK RLNDILQKAI L

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU04282.1.
RefSeq	YP_067764.1. NC_006142.1.
3D structure databases
ProteinModelPortal	Q68Y08.
ModBase	Search...
Protein-protein interaction databases
STRING	257363.RT0828.
Proteomic databases
PRIDE	Q68Y08.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAU04282; AAU04282; RT0828.
GeneID	2959007.
KEGG	rty:RT0828.
PATRIC	17910908. VBIRicTyp34752_0845.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0326.
HOGENOM	HOG000031989.
KO	K04079.
OMA	LTDSPAC.
ProtClustDB	PRK05218.
Enzyme and pathway databases
BioCyc	RTYP257363:GJEQ-868-MONOMER.
Family and domain databases
Gene3D	3.30.565.10. 1 hit.
HAMAP	MF_00505. HSP90.
InterPro	IPR003594. HATPase_ATP-bd. IPR019805. Heat_shock_protein_90_CS. IPR001404. Hsp90. IPR020575. Hsp90_N. IPR020568. Ribosomal_S5_D2-typ_fold. [Graphical view]
PANTHER	PTHR11528. PTHR11528. 1 hit.
Pfam	PF00183. HSP90. 1 hit. [Graphical view]
PIRSF	PIRSF002583. Hsp90. 1 hit.
PRINTS	PR00775. HEATSHOCK90.
SMART	SM00387. HATPase_c. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
PROSITE	PS00298. HSP90. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HTPG_RICTY

Accession

Primary (citable) accession number: Q68Y08

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program