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Q68Y02

- TADA_RICTY

UniProt

Q68Y02 - TADA_RICTY

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Protein

tRNA-specific adenosine deaminase

Gene

tadA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).UniRule annotation

Catalytic activityi

Adenine(34) in tRNA + H2O = hypoxanthine(34) in tRNA + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi48 – 481Zinc; via pros nitrogen; catalyticUniRule annotation
Active sitei50 – 501Proton donorUniRule annotation
Metal bindingi78 – 781Zinc; catalyticUniRule annotation
Metal bindingi81 – 811Zinc; catalyticUniRule annotation

GO - Molecular functioni

  1. tRNA-specific adenosine-34 deaminase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. tRNA wobble adenosine to inosine editing Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-859-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-specific adenosine deaminaseUniRule annotation (EC:3.5.4.33UniRule annotation)
Gene namesi
Name:tadAUniRule annotation
Ordered Locus Names:RT0819
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 148148tRNA-specific adenosine deaminasePRO_0000293138Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0819.

Structurei

3D structure databases

ProteinModelPortaliQ68Y02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9696CMP/dCMP deaminase zinc-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cytidine and deoxycytidylate deaminase family.UniRule annotation
Contains 1 CMP/dCMP deaminase zinc-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0590.
HOGENOMiHOG000085050.
KOiK01485.
OMAiSQPTCHH.
OrthoDBiEOG64FKGZ.

Family and domain databases

HAMAPiMF_00972. tRNA_aden_deaminase.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR028883. tRNA_aden_deaminase.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68Y02-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQALKQARL AFDKNEVPVG VVIVYRLNQK IIVSSHNNIE EKNNALCHAE
60 70 80 90 100
IIAINEACNL ISSKNLNDYD IYVTLEPCAM CASAISHSRL KRLFYGASDS
110 120 130 140
KQGAVESNLR YFNSSACFHR PEIYSGILSE HSRFLMKEFF QKMRSTID
Length:148
Mass (Da):16,823
Last modified:October 11, 2004 - v1
Checksum:iC78F020EC98F73C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU04274.1.
RefSeqiYP_067756.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU04274; AAU04274; RT0819.
GeneIDi2958939.
KEGGirty:RT0819.
PATRICi17910888. VBIRicTyp34752_0836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU04274.1 .
RefSeqi YP_067756.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68Y02.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0819.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU04274 ; AAU04274 ; RT0819 .
GeneIDi 2958939.
KEGGi rty:RT0819.
PATRICi 17910888. VBIRicTyp34752_0836.

Phylogenomic databases

eggNOGi COG0590.
HOGENOMi HOG000085050.
KOi K01485.
OMAi SQPTCHH.
OrthoDBi EOG64FKGZ.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-859-MONOMER.

Family and domain databases

HAMAPi MF_00972. tRNA_aden_deaminase.
InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR028883. tRNA_aden_deaminase.
[Graphical view ]
Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53927. SSF53927. 1 hit.
PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiTADA_RICTY
AccessioniPrimary (citable) accession number: Q68Y02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 11, 2004
Last modified: November 26, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3