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Q68Y02

- TADA_RICTY

UniProt

Q68Y02 - TADA_RICTY

Protein

tRNA-specific adenosine deaminase

Gene

tadA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).UniRule annotation

    Catalytic activityi

    Adenine(34) in tRNA + H2O = hypoxanthine(34) in tRNA + NH3.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi48 – 481Zinc; via pros nitrogen; catalyticUniRule annotation
    Active sitei50 – 501Proton donorUniRule annotation
    Metal bindingi78 – 781Zinc; catalyticUniRule annotation
    Metal bindingi81 – 811Zinc; catalyticUniRule annotation

    GO - Molecular functioni

    1. tRNA-specific adenosine-34 deaminase activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tRNA wobble adenosine to inosine editing Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-859-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA-specific adenosine deaminaseUniRule annotation (EC:3.5.4.33UniRule annotation)
    Gene namesi
    Name:tadAUniRule annotation
    Ordered Locus Names:RT0819
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 148148tRNA-specific adenosine deaminasePRO_0000293138Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi257363.RT0819.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68Y02.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 9696CMP/dCMP deaminase zinc-bindingUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cytidine and deoxycytidylate deaminase family.UniRule annotation
    Contains 1 CMP/dCMP deaminase zinc-binding domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0590.
    HOGENOMiHOG000085050.
    KOiK01485.
    OMAiSQPTCHH.
    OrthoDBiEOG64FKGZ.

    Family and domain databases

    HAMAPiMF_00972. tRNA_aden_deaminase.
    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR028883. tRNA_aden_deaminase.
    [Graphical view]
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53927. SSF53927. 1 hit.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68Y02-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQALKQARL AFDKNEVPVG VVIVYRLNQK IIVSSHNNIE EKNNALCHAE    50
    IIAINEACNL ISSKNLNDYD IYVTLEPCAM CASAISHSRL KRLFYGASDS 100
    KQGAVESNLR YFNSSACFHR PEIYSGILSE HSRFLMKEFF QKMRSTID 148
    Length:148
    Mass (Da):16,823
    Last modified:October 11, 2004 - v1
    Checksum:iC78F020EC98F73C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04274.1.
    RefSeqiYP_067756.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU04274; AAU04274; RT0819.
    GeneIDi2958939.
    KEGGirty:RT0819.
    PATRICi17910888. VBIRicTyp34752_0836.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04274.1 .
    RefSeqi YP_067756.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68Y02.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0819.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU04274 ; AAU04274 ; RT0819 .
    GeneIDi 2958939.
    KEGGi rty:RT0819.
    PATRICi 17910888. VBIRicTyp34752_0836.

    Phylogenomic databases

    eggNOGi COG0590.
    HOGENOMi HOG000085050.
    KOi K01485.
    OMAi SQPTCHH.
    OrthoDBi EOG64FKGZ.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-859-MONOMER.

    Family and domain databases

    HAMAPi MF_00972. tRNA_aden_deaminase.
    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR028883. tRNA_aden_deaminase.
    [Graphical view ]
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53927. SSF53927. 1 hit.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiTADA_RICTY
    AccessioniPrimary (citable) accession number: Q68Y02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3