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Q68Y02 (TADA_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
tRNA-specific adenosine deaminase

EC=3.5.4.33
Gene names
Name:tadA
Ordered Locus Names:RT0819
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length148 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) By similarity. HAMAP-Rule MF_00972

Catalytic activity

Adenine34 in tRNA + H2O = hypoxanthine34 in tRNA + NH3. HAMAP-Rule MF_00972

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00972

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00972

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Contains 1 CMP/dCMP deaminase zinc-binding domain.

Ontologies

Keywords
   Biological processtRNA processing
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtRNA wobble adenosine to inosine editing

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functiontRNA-specific adenosine-34 deaminase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 148148tRNA-specific adenosine deaminase HAMAP-Rule MF_00972
PRO_0000293138

Regions

Domain1 – 9696CMP/dCMP deaminase zinc-binding

Sites

Active site501Proton donor By similarity
Metal binding481Zinc; via pros nitrogen; catalytic By similarity
Metal binding781Zinc; catalytic By similarity
Metal binding811Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68Y02 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: C78F020EC98F73C4

FASTA14816,823
        10         20         30         40         50         60 
MEQALKQARL AFDKNEVPVG VVIVYRLNQK IIVSSHNNIE EKNNALCHAE IIAINEACNL 

        70         80         90        100        110        120 
ISSKNLNDYD IYVTLEPCAM CASAISHSRL KRLFYGASDS KQGAVESNLR YFNSSACFHR 

       130        140 
PEIYSGILSE HSRFLMKEFF QKMRSTID 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU04274.1.
RefSeqYP_067756.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68Y02.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0819.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU04274; AAU04274; RT0819.
GeneID2958939.
KEGGrty:RT0819.
PATRIC17910888. VBIRicTyp34752_0836.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0590.
HOGENOMHOG000085050.
KOK01485.
OMASQPTCHH.
OrthoDBEOG64FKGZ.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-859-MONOMER.

Family and domain databases

HAMAPMF_00972. tRNA_aden_deaminase.
InterProIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR028883. tRNA_aden_deaminase.
[Graphical view]
PfamPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMSSF53927. SSF53927. 1 hit.
PROSITEPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTADA_RICTY
AccessionPrimary (citable) accession number: Q68Y02
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names