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Q68Y02

- TADA_RICTY

UniProt

Q68Y02 - TADA_RICTY

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Protein

tRNA-specific adenosine deaminase

Gene
tadA, RT0819
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) By similarity.UniRule annotation

Catalytic activityi

Adenine(34) in tRNA + H2O = hypoxanthine(34) in tRNA + NH3.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi48 – 481Zinc; via pros nitrogen; catalytic By similarity
Active sitei50 – 501Proton donor By similarity
Metal bindingi78 – 781Zinc; catalytic By similarity
Metal bindingi81 – 811Zinc; catalytic By similarity

GO - Molecular functioni

  1. tRNA-specific adenosine-34 deaminase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. tRNA wobble adenosine to inosine editing Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-859-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-specific adenosine deaminase (EC:3.5.4.33)
Gene namesi
Name:tadA
Ordered Locus Names:RT0819
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 148148tRNA-specific adenosine deaminaseUniRule annotationPRO_0000293138Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0819.

Structurei

3D structure databases

ProteinModelPortaliQ68Y02.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9696CMP/dCMP deaminase zinc-bindingAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0590.
HOGENOMiHOG000085050.
KOiK01485.
OMAiSQPTCHH.
OrthoDBiEOG64FKGZ.

Family and domain databases

HAMAPiMF_00972. tRNA_aden_deaminase.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR028883. tRNA_aden_deaminase.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68Y02-1 [UniParc]FASTAAdd to Basket

« Hide

MEQALKQARL AFDKNEVPVG VVIVYRLNQK IIVSSHNNIE EKNNALCHAE    50
IIAINEACNL ISSKNLNDYD IYVTLEPCAM CASAISHSRL KRLFYGASDS 100
KQGAVESNLR YFNSSACFHR PEIYSGILSE HSRFLMKEFF QKMRSTID 148
Length:148
Mass (Da):16,823
Last modified:October 11, 2004 - v1
Checksum:iC78F020EC98F73C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU04274.1.
RefSeqiYP_067756.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU04274; AAU04274; RT0819.
GeneIDi2958939.
KEGGirty:RT0819.
PATRICi17910888. VBIRicTyp34752_0836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU04274.1 .
RefSeqi YP_067756.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68Y02.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0819.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU04274 ; AAU04274 ; RT0819 .
GeneIDi 2958939.
KEGGi rty:RT0819.
PATRICi 17910888. VBIRicTyp34752_0836.

Phylogenomic databases

eggNOGi COG0590.
HOGENOMi HOG000085050.
KOi K01485.
OMAi SQPTCHH.
OrthoDBi EOG64FKGZ.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-859-MONOMER.

Family and domain databases

HAMAPi MF_00972. tRNA_aden_deaminase.
InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR028883. tRNA_aden_deaminase.
[Graphical view ]
Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53927. SSF53927. 1 hit.
PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiTADA_RICTY
AccessioniPrimary (citable) accession number: Q68Y02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi