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Q68XZ6

- LPXA_RICTY

UniProt

Q68XZ6 - LPXA_RICTY

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Protein
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Gene
lpxA, RT0006
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-6-MONOMER.
UniPathwayiUPA00359; UER00477.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (EC:2.3.1.129)
Short name:
UDP-N-acetylglucosamine acyltransferase
Gene namesi
Name:lpxA
Ordered Locus Names:RT0006
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseUniRule annotation
PRO_0000273129Add
BLAST

Interactioni

Subunit structurei

Homotrimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0006.

Structurei

3D structure databases

ProteinModelPortaliQ68XZ6.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1043.
HOGENOMiHOG000294326.
KOiK00677.
OMAiDHIKLND.
OrthoDBiEOG6F81P1.

Family and domain databases

Gene3Di1.20.1180.10. 1 hit.
HAMAPiMF_00387. LpxA.
InterProiIPR029098. Acetyltransf_C.
IPR001451. Hexapep_transf.
IPR010137. Lipid_A_LpxA.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF13720. Acetyltransf_11. 1 hit.
PF00132. Hexapep. 3 hits.
[Graphical view]
PIRSFiPIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01852. lipid_A_lpxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68XZ6-1 [UniParc]FASTAAdd to Basket

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MSNSNIHTTA IIAEGAKFGK NVKVGPYCII GPEVVLHDNV ELKSHVVIDG    50
ITEIGENTVI YPFASIGQPP QILKYANERS STIIGSNNTI REYVTVQAGS 100
KSGGMITRVG NNNLFMVGVH IGHDCKIGNN LVFANYVSLA GHIKVGDYAI 150
IGGLSAVHQY TRIGEYSMIG GLSPVSADVI PFGLVSSKRA VLEGLNLIGM 200
NRKGFDKVDS LTALNAVEEI FLGKGNFADR IKQVAEKYKN NSIVTQIIDF 250
LNQDSSRSFC HFKK 264
Length:264
Mass (Da):28,516
Last modified:October 11, 2004 - v1
Checksum:i9089EA5C76AE6C11
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03496.1.
RefSeqiYP_066978.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03496; AAU03496; RT0006.
GeneIDi2958533.
KEGGirty:RT0006.
PATRICi17909162. VBIRicTyp34752_0006.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03496.1 .
RefSeqi YP_066978.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68XZ6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 257363.RT0006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03496 ; AAU03496 ; RT0006 .
GeneIDi 2958533.
KEGGi rty:RT0006.
PATRICi 17909162. VBIRicTyp34752_0006.

Phylogenomic databases

eggNOGi COG1043.
HOGENOMi HOG000294326.
KOi K00677.
OMAi DHIKLND.
OrthoDBi EOG6F81P1.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00477 .
BioCyci RTYP257363:GJEQ-6-MONOMER.

Family and domain databases

Gene3Di 1.20.1180.10. 1 hit.
HAMAPi MF_00387. LpxA.
InterProi IPR029098. Acetyltransf_C.
IPR001451. Hexapep_transf.
IPR010137. Lipid_A_LpxA.
IPR011004. Trimer_LpxA-like.
[Graphical view ]
Pfami PF13720. Acetyltransf_11. 1 hit.
PF00132. Hexapep. 3 hits.
[Graphical view ]
PIRSFi PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAMi SSF51161. SSF51161. 1 hit.
TIGRFAMsi TIGR01852. lipid_A_lpxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiLPXA_RICTY
AccessioniPrimary (citable) accession number: Q68XZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi