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Protein

Probable tRNA-dihydrouridine synthase

Gene

dus

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.By similarity

Catalytic activityi

5,6-dihydrouracil in tRNA + NAD(P)+ = uracil in tRNA + NAD(P)H.By similarity

Cofactori

FMNBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei72FMNBy similarity1
Active sitei102Proton donorBy similarity1
Binding sitei141FMNBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 19FMNBy similarity3
Nucleotide bindingi202 – 204FMNBy similarity3
Nucleotide bindingi226 – 227FMNBy similarity2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Flavoprotein, FMN, NADP, RNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA-dihydrouridine synthase (EC:1.3.1.-)
Gene namesi
Name:dus
Ordered Locus Names:RT0010
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000000604 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002809611 – 327Probable tRNA-dihydrouridine synthaseAdd BLAST327

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0010.

Structurei

3D structure databases

ProteinModelPortaliQ68XZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Dus family.Curated

Phylogenomic databases

eggNOGiENOG4105CEH. Bacteria.
COG0042. LUCA.
HOGENOMiHOG000217855.
OMAiTIKMRKG.
OrthoDBiPOG091H02GM.

Family and domain databases

Gene3Di1.10.1200.80. 1 hit.
3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR024036. tRNA-dHydroUridine_Synthase_C.
IPR004652. tRNA_dU_NifR3.
IPR001269. tRNA_hU_synthase.
IPR018517. tRNA_hU_synthase_CS.
[Graphical view]
PANTHERiPTHR11082. PTHR11082. 1 hit.
PfamiPF01207. Dus. 1 hit.
[Graphical view]
PIRSFiPIRSF006621. Dus. 1 hit.
TIGRFAMsiTIGR00737. nifR3_yhdG. 1 hit.
PROSITEiPS01136. UPF0034. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68XZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKIGNIELS SNVILAPMSN ITDLEFRKLV KRFGAGLVVS EMIASRAMIM
60 70 80 90 100
KSRQSMQKCA IMHDDPTSAC VQLAGCEPDV IADAAKMNED MGAKIIDLNF
110 120 130 140 150
GCPAKKVVGG YAGSALMRDE RLATKIFEAT VKAVKIPVTV KMRMGWDDNT
160 170 180 190 200
KNAPTLAVIA ASSGVQMVTV HGRTRCQFYS GNANWDFIRV VKEAVKIPVI
210 220 230 240 250
ANGDITNFAK AKEALQKSGA DGIMVGRGVY GKPWLISQIA YYLKTGKEKP
260 270 280 290 300
APSIAEQLDI IIKHYDAIID YYGKSVGVPI ARKHIIWYSS GLPSSAEFRC
310 320
AVNLMNDPIA VKEKIAEFYM SVMDANK
Length:327
Mass (Da):35,691
Last modified:October 11, 2004 - v1
Checksum:iAB4DD899752814E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03499.1.
RefSeqiWP_011190486.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03499; AAU03499; RT0010.
KEGGirty:RT0010.
PATRICi17909170. VBIRicTyp34752_0009.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03499.1.
RefSeqiWP_011190486.1. NC_006142.1.

3D structure databases

ProteinModelPortaliQ68XZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU03499; AAU03499; RT0010.
KEGGirty:RT0010.
PATRICi17909170. VBIRicTyp34752_0009.

Phylogenomic databases

eggNOGiENOG4105CEH. Bacteria.
COG0042. LUCA.
HOGENOMiHOG000217855.
OMAiTIKMRKG.
OrthoDBiPOG091H02GM.

Family and domain databases

Gene3Di1.10.1200.80. 1 hit.
3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR024036. tRNA-dHydroUridine_Synthase_C.
IPR004652. tRNA_dU_NifR3.
IPR001269. tRNA_hU_synthase.
IPR018517. tRNA_hU_synthase_CS.
[Graphical view]
PANTHERiPTHR11082. PTHR11082. 1 hit.
PfamiPF01207. Dus. 1 hit.
[Graphical view]
PIRSFiPIRSF006621. Dus. 1 hit.
TIGRFAMsiTIGR00737. nifR3_yhdG. 1 hit.
PROSITEiPS01136. UPF0034. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDUS_RICTY
AccessioniPrimary (citable) accession number: Q68XZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.