Reviewed, UniProtKB/Swiss-Prot Q68XZ3 (DUS_RICTY)

Names and origin

Protein names

Recommended name:
    Probable tRNA-dihydrouridine synthase
    EC=1.-.-.-

Gene names

Name:	dus
Ordered Locus Names:	RT0010

Organism

Rickettsia typhi [Complete proteome] [HAMAP]

Taxonomic identifier

785 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs By similarity.
Cofactor	FAD By similarity.
Sequence similarities	Belongs to the dus family.

Ontologies

Keywords
Biological process	tRNA processing
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro tRNA dihydrouridine synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 327	327	Probable tRNA-dihydrouridine synthase		PRO_0000280961

Sequences

	Sequence		Length	Mass (Da)
	Q68XZ3-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: AB4DD899752814E5	FASTA	327	35,691
	10 20 30 40 50 60 MIKIGNIELS SNVILAPMSN ITDLEFRKLV KRFGAGLVVS EMIASRAMIM KSRQSMQKCA 70 80 90 100 110 120 IMHDDPTSAC VQLAGCEPDV IADAAKMNED MGAKIIDLNF GCPAKKVVGG YAGSALMRDE 130 140 150 160 170 180 RLATKIFEAT VKAVKIPVTV KMRMGWDDNT KNAPTLAVIA ASSGVQMVTV HGRTRCQFYS 190 200 210 220 230 240 GNANWDFIRV VKEAVKIPVI ANGDITNFAK AKEALQKSGA DGIMVGRGVY GKPWLISQIA 250 260 270 280 290 300 YYLKTGKEKP APSIAEQLDI IIKHYDAIID YYGKSVGVPI ARKHIIWYSS GLPSSAEFRC 310 320 AVNLMNDPIA VKEKIAEFYM SVMDANK

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017197 Genomic DNA. Translation: AAU03499.1.
RefSeq	YP_066981.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2958537.
GenomeReviews	Gene locus RT0010 in contig AE017197_GR.
KEGG	rty:RT0010.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q68XZ3.
OMA	QLAGCEP
Enzyme and pathway databases
BioCyc	RTYP257363:RT0010-MON.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR004652. tRNA_dU_NifR3. IPR001269. tRNA_hU_synthase. IPR018517. tRNA_hU_synthase_CS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR11082. Du_synth. 1 hit.
Pfam	PF01207. Dus. 1 hit. [Graphical view]
PIRSF	PIRSF006621. Dus. 1 hit.
TIGRFAMs	TIGR00737. nifR3_yhdG. 1 hit.
PROSITE	PS01136. UPF0034. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUS_RICTY

Accession

Primary (citable) accession number: Q68XZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	October 11, 2004
Last modified:	November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)