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Protein

Probable tRNA-dihydrouridine synthase

Gene

dus

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.By similarity

Cofactori

FADBy similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. tRNA dihydrouridine synthase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-10-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA-dihydrouridine synthase (EC:1.-.-.-)
Gene namesi
Name:dus
Ordered Locus Names:RT0010
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Probable tRNA-dihydrouridine synthasePRO_0000280961Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0010.

Structurei

3D structure databases

ProteinModelPortaliQ68XZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Dus family.Curated

Phylogenomic databases

eggNOGiCOG0042.
HOGENOMiHOG000217855.
OMAiPVGIQIF.
OrthoDBiEOG6VHZFQ.

Family and domain databases

Gene3Di1.10.1200.80. 1 hit.
3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR024036. tRNA-dHydroUridine_Synthase_C.
IPR004652. tRNA_dU_NifR3.
IPR001269. tRNA_hU_synthase.
IPR018517. tRNA_hU_synthase_CS.
[Graphical view]
PANTHERiPTHR11082. PTHR11082. 1 hit.
PfamiPF01207. Dus. 1 hit.
[Graphical view]
PIRSFiPIRSF006621. Dus. 1 hit.
TIGRFAMsiTIGR00737. nifR3_yhdG. 1 hit.
PROSITEiPS01136. UPF0034. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68XZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKIGNIELS SNVILAPMSN ITDLEFRKLV KRFGAGLVVS EMIASRAMIM
60 70 80 90 100
KSRQSMQKCA IMHDDPTSAC VQLAGCEPDV IADAAKMNED MGAKIIDLNF
110 120 130 140 150
GCPAKKVVGG YAGSALMRDE RLATKIFEAT VKAVKIPVTV KMRMGWDDNT
160 170 180 190 200
KNAPTLAVIA ASSGVQMVTV HGRTRCQFYS GNANWDFIRV VKEAVKIPVI
210 220 230 240 250
ANGDITNFAK AKEALQKSGA DGIMVGRGVY GKPWLISQIA YYLKTGKEKP
260 270 280 290 300
APSIAEQLDI IIKHYDAIID YYGKSVGVPI ARKHIIWYSS GLPSSAEFRC
310 320
AVNLMNDPIA VKEKIAEFYM SVMDANK
Length:327
Mass (Da):35,691
Last modified:October 10, 2004 - v1
Checksum:iAB4DD899752814E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03499.1.
RefSeqiYP_066981.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03499; AAU03499; RT0010.
GeneIDi2958537.
KEGGirty:RT0010.
PATRICi17909170. VBIRicTyp34752_0009.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03499.1.
RefSeqiYP_066981.1. NC_006142.1.

3D structure databases

ProteinModelPortaliQ68XZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU03499; AAU03499; RT0010.
GeneIDi2958537.
KEGGirty:RT0010.
PATRICi17909170. VBIRicTyp34752_0009.

Phylogenomic databases

eggNOGiCOG0042.
HOGENOMiHOG000217855.
OMAiPVGIQIF.
OrthoDBiEOG6VHZFQ.

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-10-MONOMER.

Family and domain databases

Gene3Di1.10.1200.80. 1 hit.
3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR024036. tRNA-dHydroUridine_Synthase_C.
IPR004652. tRNA_dU_NifR3.
IPR001269. tRNA_hU_synthase.
IPR018517. tRNA_hU_synthase_CS.
[Graphical view]
PANTHERiPTHR11082. PTHR11082. 1 hit.
PfamiPF01207. Dus. 1 hit.
[Graphical view]
PIRSFiPIRSF006621. Dus. 1 hit.
TIGRFAMsiTIGR00737. nifR3_yhdG. 1 hit.
PROSITEiPS01136. UPF0034. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiDUS_RICTY
AccessioniPrimary (citable) accession number: Q68XZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 19, 2007
Last sequence update: October 10, 2004
Last modified: January 6, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.