Reviewed, UniProtKB/Swiss-Prot Q68XY6 (ERA_RICTY)

Names and origin

Protein names

Recommended name:
    GTP-binding protein era homolog

Gene names

Name:	era
Ordered Locus Names:	RT0018

Organism

Rickettsia typhi [Complete proteome] [HAMAP]

Taxonomic identifier

785 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Binds both GDP and GTP, has an intrinsic GTPase activity and is essential for cell growth By similarity.
Sequence similarities	Belongs to the era/mnmE GTP-binding protein family. Era subfamily. Contains 1 KH type-2 domain.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding RNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: HAMAP RNA binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 295	295	GTP-binding protein era homolog HAMAP MF_00367		PRO_0000278006
Regions
	Domain	204 – 281	78	KH type-2
	Nucleotide binding	15 – 22	8	GTP Potential
	Nucleotide binding	62 – 66	5	GTP Potential
	Nucleotide binding	124 – 127	4	GTP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q68XY6-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: CB54FB2EB0C22A0F	FASTA	295	33,745
	10 20 30 40 50 60 MINQIQKTIS VCIIGRPNSG KSTLLNRIIG EKLSIVTPKV QTTRSIITGI ITLKDTQIIL 70 80 90 100 110 120 YDTPGIFEPK GMLEKAMVRC AWSSLYSADL VLSIIDSLKP LDDMAHNILN QFCLLNIVPI 130 140 150 160 170 180 FLLNKIDIES KYLNDIKAFL KISHPKSLLF PISALCGKNV DVLLKYIKSK AKVSPWLYAD 190 200 210 220 230 240 DDITNLPMRF IAAEITREQL FLNLQQELPY KLTVQTEKFE ELKDKSIKIN QVIVISRESY 250 260 270 280 290 KAIILGKNGT KIKDIGVKSR IQMEQLFCVP VHLFLFVKVH ALWENKQEFY QYMKI

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017197 Genomic DNA. Translation: AAU03506.1.
RefSeq	YP_066988.1.
3D structure databases
HSSP	HSSP built from PDB template 1MKY based on UniProtKB Q9X1F8.
ModBase	Search...
Genome annotation databases
GeneID	2958605.
GenomeReviews	Gene locus RT0018 in contig AE017197_GR.
KEGG	rty:RT0018.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q68XY6.
OMA	ITREQLF
Enzyme and pathway databases
BioCyc	RTYP257363:RT0018-MON.
Family and domain databases
HAMAP	MF_00367. [Tree]
InterPro	IPR005662. Era_GTP_bd. IPR015946. KH-like_a/b. IPR009019. KH_prok-type. IPR004044. KH_type_2. IPR002917. MMR_HSR1_GTP_bd. IPR005225. Small_GTP_bd. [Graphical view]
Gene3D	G3DSA:3.30.300.20. KH_prok. 1 hit.
Pfam	PF07650. KH_2. 1 hit. PF01926. MMR_HSR1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00436. era. 1 hit. TIGR00231. small_GTP. 1 hit.
PROSITE	PS50823. KH_TYPE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ERA_RICTY

Accession

Primary (citable) accession number: Q68XY6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	October 11, 2004
Last modified:	November 24, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)