Q68XY6 (ERA_RICTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTPase Era

Gene names

Name:	era
Ordered Locus Names:	RT0018

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism By similarity. HAMAP MF_00367
Subunit structure	Monomer By similarity. HAMAP MF_00367
Subcellular location	Cytoplasm. Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_00367.
Sequence similarities	Belongs to the Era/MnmE GTP-binding protein family. Era subfamily. Contains 1 G (guanine nucleotide-binding) domain. Contains 1 KH type-2 domain.

Ontologies

Keywords
Biological process	Ribosome biogenesis
Cellular component	Cell inner membrane Cell membrane Cytoplasm Membrane
Ligand	GTP-binding Nucleotide-binding RNA-binding rRNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ribosome biogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 295	295	GTPase Era HAMAP MF_00367		PRO_0000278006
Regions
	Domain	20 – 125	106	G
	Domain	204 – 281	78	KH type-2
	Nucleotide binding	15 – 22	8	GTP Potential
	Nucleotide binding	62 – 66	5	GTP Potential
	Nucleotide binding	124 – 127	4	GTP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q68XY6 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: CB54FB2EB0C22A0F	FASTA	295	33,745
	10 20 30 40 50 60 MINQIQKTIS VCIIGRPNSG KSTLLNRIIG EKLSIVTPKV QTTRSIITGI ITLKDTQIIL 70 80 90 100 110 120 YDTPGIFEPK GMLEKAMVRC AWSSLYSADL VLSIIDSLKP LDDMAHNILN QFCLLNIVPI 130 140 150 160 170 180 FLLNKIDIES KYLNDIKAFL KISHPKSLLF PISALCGKNV DVLLKYIKSK AKVSPWLYAD 190 200 210 220 230 240 DDITNLPMRF IAAEITREQL FLNLQQELPY KLTVQTEKFE ELKDKSIKIN QVIVISRESY 250 260 270 280 290 KAIILGKNGT KIKDIGVKSR IQMEQLFCVP VHLFLFVKVH ALWENKQEFY QYMKI

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU03506.1.
RefSeq	YP_066988.1. NC_006142.1.
3D structure databases
HSSP	HSSP built from PDB template 1MKY based on UniProtKB Q9X1F8.
ProteinModelPortal	Q68XY6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2958605.
GenomeReviews	Gene locus RT0018 in contig AE017197_GR.
KEGG	rty:RT0018.
PATRIC	17909186. VBIRicTyp34752_0016.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG561652.
OMA	ITREQLF.
ProtClustDB	PRK00089.
Enzyme and pathway databases
BioCyc	RTYP257363:RT0018-MONOMER.
Family and domain databases
HAMAP	MF_00367. GTPase_Era. [Tree]
InterPro	IPR005662. GTP-bd_Era. IPR006073. GTP_binding_domain. IPR015946. KH_dom-like_a/b. IPR009019. KH_prok-type. IPR004044. KH_type_2. IPR005225. Small_GTP-bd_dom. [Graphical view]
Gene3D	G3DSA:3.30.300.20. KH_prok. 1 hit.
KO	K03595.
Pfam	PF07650. KH_2. 1 hit. PF01926. MMR_HSR1. 1 hit. [Graphical view]
SUPFAM	SSF54814. KH_prok. 1 hit.
TIGRFAMs	TIGR00436. Era. 1 hit. TIGR00231. Small_GTP. 1 hit.
PROSITE	PS50823. KH_TYPE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ERA_RICTY

Accession

Primary (citable) accession number: Q68XY6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program