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Protein

Protein translocase subunit SecF

Gene

secF

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.UniRule annotation

GO - Molecular functioni

  1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
  2. protein targeting Source: UniProtKB-HAMAP
  3. protein transport by the Sec complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-23-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecF
Gene namesi
Name:secFUniRule annotation
Ordered Locus Names:RT0022
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604 Componenti: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4220HelicalUniRule annotationAdd
BLAST
Transmembranei140 – 16021HelicalUniRule annotationAdd
BLAST
Transmembranei164 – 18421HelicalUniRule annotationAdd
BLAST
Transmembranei194 – 21421HelicalUniRule annotationAdd
BLAST
Transmembranei246 – 26621HelicalUniRule annotationAdd
BLAST
Transmembranei272 – 29221HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. intracellular Source: GOC
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Protein translocase subunit SecFPRO_0000272640Add
BLAST

Interactioni

Subunit structurei

Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0022.

Structurei

3D structure databases

ProteinModelPortaliQ68XY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecD/SecF family. SecF subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0341.
HOGENOMiHOG000245916.
KOiK03074.
OMAiMWLGVKR.
OrthoDBiEOG676Z5R.

Family and domain databases

HAMAPiMF_01464_B. SecF_B.
InterProiIPR022813. SecD/SecF_arch_bac.
IPR022645. SecD/SecF_bac.
IPR022646. SecD/SecF_CS.
IPR005665. SecF_bac.
[Graphical view]
PfamiPF07549. Sec_GG. 1 hit.
PF02355. SecD_SecF. 1 hit.
[Graphical view]
PRINTSiPR01755. SECFTRNLCASE.
TIGRFAMsiTIGR00916. 2A0604s01. 1 hit.
TIGR00966. 3a0501s07. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68XY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIYPLRFVP NKINFDFMNF KKVSYSFSII LSLISLIWIG IYKFNFGIDF
60 70 80 90 100
VGGIVIEVRL DRAPDLPKMR AVLSALGIGE VVLQNFESEH DLSIRFGSSS
110 120 130 140 150
EENLMKNIDI IKTSLRNNFP YNFEYRKVDF VGPQVGRHLI EAGAMAMLFS
160 170 180 190 200
FLAIMVYIGV RFEWYFGFGI LIALVHDVIL ALGFMSITKL DFNLSTIAAV
210 220 230 240 250
LTIIGYSVND SVVIYDRIRE NLRKYHKKNI TEIINLSINE TLSRTILTVI
260 270 280 290 300
TTLLANLALI LFGGKAIHSF SVLVFFGIIA GTYSSIFISA PILTIFANRK

FNKKVIER
Length:308
Mass (Da):34,940
Last modified:October 10, 2004 - v1
Checksum:i7E1FB0CC35708C73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03510.1.
RefSeqiYP_066992.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03510; AAU03510; RT0022.
GeneIDi2958489.
KEGGirty:RT0022.
PATRICi17909194. VBIRicTyp34752_0020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03510.1.
RefSeqiYP_066992.1. NC_006142.1.

3D structure databases

ProteinModelPortaliQ68XY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0022.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU03510; AAU03510; RT0022.
GeneIDi2958489.
KEGGirty:RT0022.
PATRICi17909194. VBIRicTyp34752_0020.

Phylogenomic databases

eggNOGiCOG0341.
HOGENOMiHOG000245916.
KOiK03074.
OMAiMWLGVKR.
OrthoDBiEOG676Z5R.

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-23-MONOMER.

Family and domain databases

HAMAPiMF_01464_B. SecF_B.
InterProiIPR022813. SecD/SecF_arch_bac.
IPR022645. SecD/SecF_bac.
IPR022646. SecD/SecF_CS.
IPR005665. SecF_bac.
[Graphical view]
PfamiPF07549. Sec_GG. 1 hit.
PF02355. SecD_SecF. 1 hit.
[Graphical view]
PRINTSiPR01755. SECFTRNLCASE.
TIGRFAMsiTIGR00916. 2A0604s01. 1 hit.
TIGR00966. 3a0501s07. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiSECF_RICTY
AccessioniPrimary (citable) accession number: Q68XY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 22, 2007
Last sequence update: October 10, 2004
Last modified: January 6, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.