Reviewed, UniProtKB/Swiss-Prot Q68XX8 (ACKA_RICTY)

Names and origin

Protein names

Recommended name:
    Acetate kinase
    EC=2.7.2.1
Alternative name(s):
    Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	RT0026

Organism

Rickettsia typhi [Complete proteome] [HAMAP]

Taxonomic identifier

785 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	385 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro phosphorylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 385	385	Acetate kinase HAMAP MF_00020		PRO_0000107606

Sequences

	Sequence		Length	Mass (Da)
	Q68XX8-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 6226C8A5676DA515	FASTA	385	43,381
	10 20 30 40 50 60 MKDVILIANA GSSSLKISIF GIQNKKVKDK IYNIFLEKNN NKILFYINQK QESAISIKDN 70 80 90 100 110 120 AIEMMINLFE EWWTKQSALN LIATGHRIVH GGKNFNKPVI VNEKIIKELR VLIPLSPLHQ 130 140 150 160 170 180 PYNLQVLDLF FQKYKDISHI ICFDTSFHYT NPPITKAFGL PKQYYDKGIM RYGFHGLSYQ 190 200 210 220 230 240 YVSSHFKEIT MEDLPTKTII AHLGSGSSLC AIKNGLSLTS SMGFSVLDGV MMATRTGNLD 250 260 270 280 290 300 PGVVLYLINH EKMTMKEITE LLYKKSGLLG ISGESSDMRT LITNNSHDSK FAVELFVYRI 310 320 330 340 350 360 VLEIGKLIAA LEGIDCIIFT AGIGQNSAVI REMISGKLSW LGIKIDYGKN QKNEHRISTK 370 380 GSKVKVFVVP TNEELIIAEE VMKFL

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017197 Genomic DNA. Translation: AAU03514.1.
RefSeq	YP_066996.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2958568.
GenomeReviews	Gene locus RT0026 in contig AE017197_GR.
KEGG	rty:RT0026.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q68XX8.
OMA	SAVIREM
Enzyme and pathway databases
BioCyc	RTYP257363:RT0026-MON.
BRENDA	2.7.2.1. 281221.
Family and domain databases
HAMAP	MF_00020. [Tree]
InterPro	IPR000890. Acetate/butyrate_kinase. IPR004372. AckA. [Graphical view]
PANTHER	PTHR21060. Acetate_kin. 1 hit. PTHR21060:SF11. AckA. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. ackA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_RICTY

Accession

Primary (citable) accession number: Q68XX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	October 11, 2004
Last modified:	November 24, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)