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Protein

Acetate kinase

Gene

ackA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9MagnesiumUniRule annotation1
Binding sitei16ATPUniRule annotation1
Binding sitei87SubstrateUniRule annotation1
Active sitei144Proton donor/acceptorUniRule annotation1
Sitei175Transition state stabilizerUniRule annotation1
Sitei235Transition state stabilizerUniRule annotation1
Metal bindingi373MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 206ATPUniRule annotation5
Nucleotide bindingi277 – 279ATPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:RT0026
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000000604 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001076061 – 385Acetate kinaseAdd BLAST385

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0026.

Structurei

3D structure databases

ProteinModelPortaliQ68XX8.
SMRiQ68XX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H. Bacteria.
COG0282. LUCA.
HOGENOMiHOG000288399.
KOiK00925.
OMAiFMMQKEN.
OrthoDBiPOG091H02K4.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68XX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDVILIANA GSSSLKISIF GIQNKKVKDK IYNIFLEKNN NKILFYINQK
60 70 80 90 100
QESAISIKDN AIEMMINLFE EWWTKQSALN LIATGHRIVH GGKNFNKPVI
110 120 130 140 150
VNEKIIKELR VLIPLSPLHQ PYNLQVLDLF FQKYKDISHI ICFDTSFHYT
160 170 180 190 200
NPPITKAFGL PKQYYDKGIM RYGFHGLSYQ YVSSHFKEIT MEDLPTKTII
210 220 230 240 250
AHLGSGSSLC AIKNGLSLTS SMGFSVLDGV MMATRTGNLD PGVVLYLINH
260 270 280 290 300
EKMTMKEITE LLYKKSGLLG ISGESSDMRT LITNNSHDSK FAVELFVYRI
310 320 330 340 350
VLEIGKLIAA LEGIDCIIFT AGIGQNSAVI REMISGKLSW LGIKIDYGKN
360 370 380
QKNEHRISTK GSKVKVFVVP TNEELIIAEE VMKFL
Length:385
Mass (Da):43,381
Last modified:October 11, 2004 - v1
Checksum:i6226C8A5676DA515
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03514.1.
RefSeqiWP_011190501.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03514; AAU03514; RT0026.
KEGGirty:RT0026.

Similar proteinsi

Entry informationi

Entry nameiACKA_RICTY
AccessioniPrimary (citable) accession number: Q68XX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 11, 2004
Last modified: June 7, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families