Q68XV9 (AAT_RICTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate aminotransferase
Short name=AspAT
EC=2.6.1.1

Alternative name(s):
Transaminase A

Gene names

Name:	aatA
Ordered Locus Names:	RT0046

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-aminocyclopropane-1-carboxylate synthase activity Inferred from electronic annotation. Source: InterPro L-aspartate:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 399	399	Aspartate aminotransferase		PRO_0000273126
Sites
	Binding site	39	1	Aspartate; via amide nitrogen By similarity
	Binding site	125	1	Aspartate By similarity
	Binding site	175	1	Aspartate By similarity
	Binding site	375	1	Aspartate By similarity
Amino acid modifications
	Modified residue	239	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q68XV9 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: B070EBE4775C43B8	FASTA	399	44,337
	10 20 30 40 50 60 MSIISTRLNS IKPSPTLAVV KKTLELKKAG VNIIALGAGE PDFDTPDNIK EVAITSIKDG 70 80 90 100 110 120 FTKYTNVDGI PLLKQAIKNK FKRENNIDYE LDEIIVSTGG KQVIYNLFMA SLDKGDEVII 130 140 150 160 170 180 PVPYWVSYPD MVALSTGTPI FVNCGIENNF KLTVEALERS ITDKTKWLII NSPSNPTGAG 190 200 210 220 230 240 YNCKELENIA KTLRKYPNVN IMSDDIYEHI TFDDFKFYTL AQIAPDLKER IFTVNGVSKA 250 260 270 280 290 300 YSMTGWRIGY GAGSKALIKA MTVIQSQSTS NPCSISQMAA IEALNGTQDY IKPNALNFQK 310 320 330 340 350 360 KRDLALSILE KVIYFECYKP EGAFYLFVKC DKIFGTKTKS GKIIANSNHF SEYLLEEAKV 370 380 390 AVVPGVAFGL DGYFRISYAT SMQELKEACI RIKQACNTL

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU03533.1.
RefSeq	YP_067015.1. NC_006142.1.
3D structure databases
HSSP	HSSP built from PDB template 1BKG based on UniProtKB Q56232.
ProteinModelPortal	Q68XV9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2958751.
GenomeReviews	Gene locus RT0046 in contig AE017197_GR.
KEGG	rty:RT0046.
PATRIC	17909242. VBIRicTyp34752_0043.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG645860.
OMA	MASLDKG.
ProtClustDB	PRK05764.
Enzyme and pathway databases
BioCyc	RTYP257363:RT0046-MONOMER.
Family and domain databases
InterPro	IPR001176. ACC_synthase. IPR004839. Aminotransferase_I/II. IPR004838. NHTrfase_class1_PyrdxlP-BS. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00812.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00753. ACCSYNTHASE.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AAT_RICTY

Accession

Primary (citable) accession number: Q68XV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program