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Q68XV7

- KDTA_RICTY

UniProt

Q68XV7 - KDTA_RICTY

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Protein

3-deoxy-D-manno-octulosonic acid transferase

Gene
waaA, kdtA, RT0048
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A By similarity.

Catalytic activityi

Lipid IV(A) + CMP-alpha-Kdo = alpha-Kdo-(2->6)-lipid IV(A) + CMP.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei104 – 1041Proton acceptor By similarity
Sitei174 – 1741Transition state stabilizer By similarity
Sitei249 – 2491Transition state stabilizer By similarity

GO - Molecular functioni

  1. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. lipopolysaccharide core region biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-50-MONOMER.
UniPathwayiUPA00958.

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-D-manno-octulosonic acid transferase (EC:2.4.99.12)
Short name:
Kdo transferase
Alternative name(s):
Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase
Gene namesi
Name:waaA
Synonyms:kdtA
Ordered Locus Names:RT0048
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221Helical; Signal-anchor; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4624623-deoxy-D-manno-octulosonic acid transferasePRO_0000286457Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0048.

Structurei

3D structure databases

ProteinModelPortaliQ68XV7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 9044RPE1 insertAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni308 – 3092CMP-Kdo binding By similarity
Regioni349 – 3513CMP-Kdo binding By similarity
Regioni374 – 3774CMP-Kdo binding By similarity

Sequence similaritiesi

Contains 1 RPE1 insert domain.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1519.
HOGENOMiHOG000010628.
KOiK02527.
OMAiLDHWQPD.
OrthoDBiEOG6H7FNN.

Family and domain databases

InterProiIPR007507. Glycos_transf_N.
[Graphical view]
PfamiPF04413. Glycos_transf_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68XV7-1 [UniParc]FASTAAdd to Basket

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MMLLYYILSF ILLPVYFIII FIRLLIGKED IRRIQERFAI GKQRQNSLLD    50
LQMSVNQEGF KVDTEHKATS YVYIHRNASL MYKLSLERSY AQSLVWIHAA 100
SVGEVMTSLT LIHNICKLAP NVRFLITSWT NTSAKILSTK LPKIATHQFL 150
PIDNVIFTRK FLSNWKPDLG IFIESELWPC IINEGAKHCK LLLVNARISN 200
KSFKTWLKRK KFFQLIIKNF SKIIVQSECD LQKFNALGIS DAMNLGNIKF 250
ANEKLLVNQE KLSKLSLHLD NRRVVVFAST HPEDEEVILP IINNLKEQFV 300
DCYIILIPRH PERVKSILNN CKCHNLLATA KSQNDLPVLS DDIYIVDRFG 350
EMGLFFSVAT ISFIGGSFKQ GGHNILEAAY FSNCIIFGPD MSKNTDIAKG 400
ILQNNAAIQI KNGEDLLNTL KSLLNANNAL KLKAYRENAL KFVEHNQKIL 450
DEYLHVIKPF LP 462
Length:462
Mass (Da):52,900
Last modified:October 11, 2004 - v1
Checksum:iD23F37C837B00178
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03535.1.
RefSeqiYP_067017.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03535; AAU03535; RT0048.
GeneIDi2958750.
KEGGirty:RT0048.
PATRICi17909246. VBIRicTyp34752_0045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03535.1 .
RefSeqi YP_067017.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68XV7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0048.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03535 ; AAU03535 ; RT0048 .
GeneIDi 2958750.
KEGGi rty:RT0048.
PATRICi 17909246. VBIRicTyp34752_0045.

Phylogenomic databases

eggNOGi COG1519.
HOGENOMi HOG000010628.
KOi K02527.
OMAi LDHWQPD.
OrthoDBi EOG6H7FNN.

Enzyme and pathway databases

UniPathwayi UPA00958 .
BioCyci RTYP257363:GJEQ-50-MONOMER.

Family and domain databases

InterProi IPR007507. Glycos_transf_N.
[Graphical view ]
Pfami PF04413. Glycos_transf_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiKDTA_RICTY
AccessioniPrimary (citable) accession number: Q68XV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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