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Protein

3-deoxy-D-manno-octulosonic acid transferase

Gene

waaA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.By similarity

Catalytic activityi

Lipid IV(A) + CMP-beta-Kdo = alpha-Kdo-(2->6)-lipid IV(A) + CMP.

Pathwayi: LPS core biosynthesis

This protein is involved in the pathway LPS core biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway LPS core biosynthesis and in Bacterial outer membrane biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei104Proton acceptorBy similarity1
Sitei174Transition state stabilizerBy similarity1
Sitei249Transition state stabilizerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciRTYP257363:G1G0L-49-MONOMER
UniPathwayiUPA00958

Protein family/group databases

CAZyiGT30 Glycosyltransferase Family 30

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-D-manno-octulosonic acid transferase (EC:2.4.99.12)
Short name:
Kdo transferase
Alternative name(s):
Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase
Gene namesi
Name:waaA
Synonyms:kdtA
Ordered Locus Names:RT0048
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000000604 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22Helical; Signal-anchorSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002864571 – 4623-deoxy-D-manno-octulosonic acid transferaseAdd BLAST462

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0048

Structurei

3D structure databases

ProteinModelPortaliQ68XV7
SMRiQ68XV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 90RPE1 insertAdd BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni308 – 309CMP-Kdo bindingBy similarity2
Regioni349 – 351CMP-Kdo bindingBy similarity3
Regioni374 – 377CMP-Kdo bindingBy similarity4

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D8A Bacteria
COG1519 LUCA
HOGENOMiHOG000010628
KOiK02527
OMAiFIKYEFW
OrthoDBiPOG091H01YQ

Family and domain databases

Gene3Di3.40.50.11720, 1 hit
InterProiView protein in InterPro
IPR007507 Glycos_transf_N
IPR038107 Glycos_transf_N_sf
PfamiView protein in Pfam
PF04413 Glycos_transf_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q68XV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLLYYILSF ILLPVYFIII FIRLLIGKED IRRIQERFAI GKQRQNSLLD
60 70 80 90 100
LQMSVNQEGF KVDTEHKATS YVYIHRNASL MYKLSLERSY AQSLVWIHAA
110 120 130 140 150
SVGEVMTSLT LIHNICKLAP NVRFLITSWT NTSAKILSTK LPKIATHQFL
160 170 180 190 200
PIDNVIFTRK FLSNWKPDLG IFIESELWPC IINEGAKHCK LLLVNARISN
210 220 230 240 250
KSFKTWLKRK KFFQLIIKNF SKIIVQSECD LQKFNALGIS DAMNLGNIKF
260 270 280 290 300
ANEKLLVNQE KLSKLSLHLD NRRVVVFAST HPEDEEVILP IINNLKEQFV
310 320 330 340 350
DCYIILIPRH PERVKSILNN CKCHNLLATA KSQNDLPVLS DDIYIVDRFG
360 370 380 390 400
EMGLFFSVAT ISFIGGSFKQ GGHNILEAAY FSNCIIFGPD MSKNTDIAKG
410 420 430 440 450
ILQNNAAIQI KNGEDLLNTL KSLLNANNAL KLKAYRENAL KFVEHNQKIL
460
DEYLHVIKPF LP
Length:462
Mass (Da):52,900
Last modified:October 11, 2004 - v1
Checksum:iD23F37C837B00178
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA Translation: AAU03535.1
RefSeqiWP_011190522.1, NC_006142.1

Genome annotation databases

EnsemblBacteriaiAAU03535; AAU03535; RT0048
KEGGirty:RT0048

Similar proteinsi

Entry informationi

Entry nameiKDTA_RICTY
AccessioniPrimary (citable) accession number: Q68XV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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