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Q68XV7

- KDTA_RICTY

UniProt

Q68XV7 - KDTA_RICTY

Protein

3-deoxy-D-manno-octulosonic acid transferase

Gene

waaA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A By similarity.By similarity

    Catalytic activityi

    Lipid IV(A) + CMP-alpha-Kdo = alpha-Kdo-(2->6)-lipid IV(A) + CMP.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei104 – 1041Proton acceptorBy similarity
    Sitei174 – 1741Transition state stabilizerBy similarity
    Sitei249 – 2491Transition state stabilizerBy similarity

    GO - Molecular functioni

    1. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. lipopolysaccharide core region biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-50-MONOMER.
    UniPathwayiUPA00958.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-deoxy-D-manno-octulosonic acid transferase (EC:2.4.99.12)
    Short name:
    Kdo transferase
    Alternative name(s):
    Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase
    Gene namesi
    Name:waaA
    Synonyms:kdtA
    Ordered Locus Names:RT0048
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Cell inner membrane By similarity; Single-pass membrane protein By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4624623-deoxy-D-manno-octulosonic acid transferasePRO_0000286457Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi257363.RT0048.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68XV7.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221Helical; Signal-anchorSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini47 – 9044RPE1 insertAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni308 – 3092CMP-Kdo bindingBy similarity
    Regioni349 – 3513CMP-Kdo bindingBy similarity
    Regioni374 – 3774CMP-Kdo bindingBy similarity

    Sequence similaritiesi

    Belongs to the glycosyltransferase group 1 family.Curated
    Contains 1 RPE1 insert domain.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1519.
    HOGENOMiHOG000010628.
    KOiK02527.
    OMAiLDHWQPD.
    OrthoDBiEOG6H7FNN.

    Family and domain databases

    InterProiIPR007507. Glycos_transf_N.
    [Graphical view]
    PfamiPF04413. Glycos_transf_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68XV7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMLLYYILSF ILLPVYFIII FIRLLIGKED IRRIQERFAI GKQRQNSLLD    50
    LQMSVNQEGF KVDTEHKATS YVYIHRNASL MYKLSLERSY AQSLVWIHAA 100
    SVGEVMTSLT LIHNICKLAP NVRFLITSWT NTSAKILSTK LPKIATHQFL 150
    PIDNVIFTRK FLSNWKPDLG IFIESELWPC IINEGAKHCK LLLVNARISN 200
    KSFKTWLKRK KFFQLIIKNF SKIIVQSECD LQKFNALGIS DAMNLGNIKF 250
    ANEKLLVNQE KLSKLSLHLD NRRVVVFAST HPEDEEVILP IINNLKEQFV 300
    DCYIILIPRH PERVKSILNN CKCHNLLATA KSQNDLPVLS DDIYIVDRFG 350
    EMGLFFSVAT ISFIGGSFKQ GGHNILEAAY FSNCIIFGPD MSKNTDIAKG 400
    ILQNNAAIQI KNGEDLLNTL KSLLNANNAL KLKAYRENAL KFVEHNQKIL 450
    DEYLHVIKPF LP 462
    Length:462
    Mass (Da):52,900
    Last modified:October 11, 2004 - v1
    Checksum:iD23F37C837B00178
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03535.1.
    RefSeqiYP_067017.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03535; AAU03535; RT0048.
    GeneIDi2958750.
    KEGGirty:RT0048.
    PATRICi17909246. VBIRicTyp34752_0045.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03535.1 .
    RefSeqi YP_067017.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68XV7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0048.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03535 ; AAU03535 ; RT0048 .
    GeneIDi 2958750.
    KEGGi rty:RT0048.
    PATRICi 17909246. VBIRicTyp34752_0045.

    Phylogenomic databases

    eggNOGi COG1519.
    HOGENOMi HOG000010628.
    KOi K02527.
    OMAi LDHWQPD.
    OrthoDBi EOG6H7FNN.

    Enzyme and pathway databases

    UniPathwayi UPA00958 .
    BioCyci RTYP257363:GJEQ-50-MONOMER.

    Family and domain databases

    InterProi IPR007507. Glycos_transf_N.
    [Graphical view ]
    Pfami PF04413. Glycos_transf_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiKDTA_RICTY
    AccessioniPrimary (citable) accession number: Q68XV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3