Reviewed, UniProtKB/Swiss-Prot Q68XV0 (SAM_RICTY)

Names and origin

Protein names

Recommended name:
    S-adenosylmethionine uptake transporter

Gene names

Name:	sam
Ordered Locus Names:	RT0056

Organism

Rickettsia typhi [Complete proteome] [HAMAP]

Taxonomic identifier

785 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Transports S-adenosylmethionine.
Enzyme regulation	Transport is inhibited by S-adenosylethionine and to a lesser extent by S-adenosylhomocysteine. Unlike eukaryotic transporters is not inhibited by sinfungin. Also inhibited by 2.4-dinitrophenol, suggesting transport is an energy-dependent process.
Subcellular location	Cell inner membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (TC 2.A.7.3) family. [View classification]

Ontologies

Keywords
Biological process	Amino-acid transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	amino acid transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	S-adenosylmethionine uptake transporter		PRO_0000280998
Regions
	Transmembrane	8 – 28	21	Potential
	Transmembrane	41 – 61	21	Potential
	Transmembrane	72 – 91	20	Potential
	Transmembrane	98 – 118	21	Potential
	Transmembrane	121 – 141	21	Potential
	Transmembrane	148 – 168	21	Potential
	Transmembrane	178 – 198	21	Potential
	Transmembrane	207 – 227	21	Potential
	Transmembrane	237 – 257	21	Potential
	Transmembrane	260 – 280	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q68XV0-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 34778945A87EF02A	FASTA	294	33,141
	10 20 30 40 50 60 MNDALKTYLK GICWFLLSLV TSSVNDVISK YLGTRLHSFE VAFFRFLFSS IVLLPFVVYY 70 80 90 100 110 120 GKSTLKTRHP VIHVLRGLLL FFGMTSWTYG LTIAPVTTAT VISFSIPLFT LILAVFILNE 130 140 150 160 170 180 NIIWQRWVVT VVGFIGLVVM LKPHTKDFNP EILYLILAAI SFAMLDIINK KFVVKESMLS 190 200 210 220 230 240 MLFYSAIVTA IVSLPVSMEY WITPSSFELT LLFVLGSSGS FILFFLLKAF TMVDATATAP 250 260 270 280 290 YRYLELVISA IAAYFIFNEF PDKSTAHGAV IIIPATLFIM YSEKKSMSSK HESQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.
[2]	"S-adenosylmethionine transport in Rickettsia prowazekii." Tucker A.M., Winkler H.H., Driskell L.O., Wood D.O. J. Bacteriol. 185:3031-3035(2003) [PubMed: 12730161] [Abstract] Cited for: CHARACTERIZATION. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017197 Genomic DNA. Translation: AAU03542.1.
RefSeq	YP_067024.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2958728.
GenomeReviews	Gene locus RT0056 in contig AE017197_GR.
KEGG	rty:RT0056.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q68XV0.
OMA	PVASQYW
Enzyme and pathway databases
BioCyc	RTYP257363:RT0056-MON.
Family and domain databases
InterPro	IPR000620. DUF6_TM. [Graphical view]
Pfam	PF00892. DUF6. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SAM_RICTY

Accession

Primary (citable) accession number: Q68XV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	October 11, 2004
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)