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Q68XU1

- PARC_RICTY

UniProt

Q68XU1 - PARC_RICTY

Protein

DNA topoisomerase 4 subunit A

Gene

parC

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.UniRule annotation

    Catalytic activityi

    ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei40 – 401Interaction with DNAUniRule annotation
    Sitei76 – 761Interaction with DNAUniRule annotation
    Sitei78 – 781Interaction with DNAUniRule annotation
    Sitei119 – 1191Transition state stabilizerUniRule annotation
    Active sitei120 – 1201O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. DNA binding Source: UniProtKB-HAMAP
    3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. chromosome segregation Source: UniProtKB-HAMAP
    2. DNA topological change Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase, Topoisomerase

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-68-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA topoisomerase 4 subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
    Alternative name(s):
    Topoisomerase IV subunit AUniRule annotation
    Gene namesi
    Name:parCUniRule annotation
    Ordered Locus Names:RT0065
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: InterPro
    2. extrinsic component of plasma membrane Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 737737DNA topoisomerase 4 subunit APRO_0000273115Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotetramer composed of ParC and ParE.UniRule annotation

    Protein-protein interaction databases

    STRINGi257363.RT0065.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68XU1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0188.
    HOGENOMiHOG000076277.
    KOiK02621.
    OMAiWHQETGS.
    OrthoDBiEOG661H5V.

    Family and domain databases

    Gene3Di3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPiMF_00936. ParC_type1.
    InterProiIPR024946. Arg_repress_C-like.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    IPR005742. TopoIV_A_Gneg.
    [Graphical view]
    PfamiPF03989. DNA_gyraseA_C. 2 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view]
    SMARTiSM00434. TOP4c. 1 hit.
    [Graphical view]
    SUPFAMiSSF56719. SSF56719. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q68XU1-1 [UniParc]FASTAAdd to Basket

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    MKEAKIENID FGNALSERYL AYALSTIMSR SLPDVRDGLK PVHRRLLYAM    50
    LQLRLEPNSG YKKCARVVGD VIGKYHPHGD VAVYDTLVRL AQHFSLRYPL 100
    IDGQGNFGSI DGDNAAAMRY TESRMTEICM LLMKDIDKDT VDFRSTYDDS 150
    DLEPVIMPAS FPNLLANGSE GIAVGMATNI PPHNLHELCD ALLYLIDNPQ 200
    AGVNDIMNFI KGPDFPTGGI IIDQTKVINA AYTTGRGSFR VRSRWEKEEL 250
    SYGTYQIVVT EIPYQVQKSK LIEQIAILLK DKKIPLISSI RDESTDIIRL 300
    VIEPRDRSCD PQIVMESLFK LTNLESRIQL NMNVIGSNNV PRVMNIVEIL 350
    QEFLVHRQNI ITRRSTYLLN KIKQRLEILK VLKIVYLNLD EIIEIIRRED 400
    EPKTIIMERF KISEIQVEVI LNTRLRALQK LEEHAIIDEH SNLQKQQAIL 450
    EKILKNHKEL WKIVKKEIKS VQTQFGLNTI IGARRTSFEE VDLTNQVIDI 500
    TAFITKEPIT IICSKMGWIR LLKGHNTDLS TIKYKEGDAE KFIIEAYTTD 550
    KILIISSKGR FFTLLADNIS KGKGTAVSIK LLVDIGNNDI TNILVYKPYQ 600
    LLLLASSIGK GFLVNSNEVI AQTKAGKQIM NIPEGYACIT CLPVNGNSIA 650
    CINESRRLLI FNINEIPEMK KGQGVVLQRF KNAKLLDIKI FNKEDGLSWN 700
    DGKKIQLEKN IVAFLGKRGS AGTLPPIGFP KNNRFSS 737
    Length:737
    Mass (Da):83,414
    Last modified:October 11, 2004 - v1
    Checksum:iCF736359974EBB90
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03551.1.
    RefSeqiYP_067033.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03551; AAU03551; RT0065.
    GeneIDi2958686.
    KEGGirty:RT0065.
    PATRICi17909288. VBIRicTyp34752_0065.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03551.1 .
    RefSeqi YP_067033.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68XU1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0065.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03551 ; AAU03551 ; RT0065 .
    GeneIDi 2958686.
    KEGGi rty:RT0065.
    PATRICi 17909288. VBIRicTyp34752_0065.

    Phylogenomic databases

    eggNOGi COG0188.
    HOGENOMi HOG000076277.
    KOi K02621.
    OMAi WHQETGS.
    OrthoDBi EOG661H5V.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-68-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPi MF_00936. ParC_type1.
    InterProi IPR024946. Arg_repress_C-like.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    IPR005742. TopoIV_A_Gneg.
    [Graphical view ]
    Pfami PF03989. DNA_gyraseA_C. 2 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view ]
    SMARTi SM00434. TOP4c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56719. SSF56719. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiPARC_RICTY
    AccessioniPrimary (citable) accession number: Q68XU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3