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Protein

DNA topoisomerase 4 subunit A

Gene

parC

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei40 – 401Interaction with DNAUniRule annotation
Sitei76 – 761Interaction with DNAUniRule annotation
Sitei78 – 781Interaction with DNAUniRule annotation
Sitei119 – 1191Transition state stabilizerUniRule annotation
Active sitei120 – 1201O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Topoisomerase

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-68-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 4 subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
Alternative name(s):
Topoisomerase IV subunit AUniRule annotation
Gene namesi
Name:parCUniRule annotation
Ordered Locus Names:RT0065
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 737737DNA topoisomerase 4 subunit APRO_0000273115Add
BLAST

Interactioni

Subunit structurei

Heterotetramer composed of ParC and ParE.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0065.

Structurei

3D structure databases

ProteinModelPortaliQ68XU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0188.
HOGENOMiHOG000076277.
KOiK02621.
OMAiYHRQNIV.
OrthoDBiEOG661H5V.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_00936. ParC_type1.
InterProiIPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR013760. Topo_IIA-like_dom.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR005742. TopoIV_A_Gneg.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 2 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68XU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEAKIENID FGNALSERYL AYALSTIMSR SLPDVRDGLK PVHRRLLYAM
60 70 80 90 100
LQLRLEPNSG YKKCARVVGD VIGKYHPHGD VAVYDTLVRL AQHFSLRYPL
110 120 130 140 150
IDGQGNFGSI DGDNAAAMRY TESRMTEICM LLMKDIDKDT VDFRSTYDDS
160 170 180 190 200
DLEPVIMPAS FPNLLANGSE GIAVGMATNI PPHNLHELCD ALLYLIDNPQ
210 220 230 240 250
AGVNDIMNFI KGPDFPTGGI IIDQTKVINA AYTTGRGSFR VRSRWEKEEL
260 270 280 290 300
SYGTYQIVVT EIPYQVQKSK LIEQIAILLK DKKIPLISSI RDESTDIIRL
310 320 330 340 350
VIEPRDRSCD PQIVMESLFK LTNLESRIQL NMNVIGSNNV PRVMNIVEIL
360 370 380 390 400
QEFLVHRQNI ITRRSTYLLN KIKQRLEILK VLKIVYLNLD EIIEIIRRED
410 420 430 440 450
EPKTIIMERF KISEIQVEVI LNTRLRALQK LEEHAIIDEH SNLQKQQAIL
460 470 480 490 500
EKILKNHKEL WKIVKKEIKS VQTQFGLNTI IGARRTSFEE VDLTNQVIDI
510 520 530 540 550
TAFITKEPIT IICSKMGWIR LLKGHNTDLS TIKYKEGDAE KFIIEAYTTD
560 570 580 590 600
KILIISSKGR FFTLLADNIS KGKGTAVSIK LLVDIGNNDI TNILVYKPYQ
610 620 630 640 650
LLLLASSIGK GFLVNSNEVI AQTKAGKQIM NIPEGYACIT CLPVNGNSIA
660 670 680 690 700
CINESRRLLI FNINEIPEMK KGQGVVLQRF KNAKLLDIKI FNKEDGLSWN
710 720 730
DGKKIQLEKN IVAFLGKRGS AGTLPPIGFP KNNRFSS
Length:737
Mass (Da):83,414
Last modified:October 11, 2004 - v1
Checksum:iCF736359974EBB90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03551.1.
RefSeqiWP_011190538.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03551; AAU03551; RT0065.
KEGGirty:RT0065.
PATRICi17909288. VBIRicTyp34752_0065.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03551.1.
RefSeqiWP_011190538.1. NC_006142.1.

3D structure databases

ProteinModelPortaliQ68XU1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0065.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU03551; AAU03551; RT0065.
KEGGirty:RT0065.
PATRICi17909288. VBIRicTyp34752_0065.

Phylogenomic databases

eggNOGiCOG0188.
HOGENOMiHOG000076277.
KOiK02621.
OMAiYHRQNIV.
OrthoDBiEOG661H5V.

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-68-MONOMER.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_00936. ParC_type1.
InterProiIPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR013760. Topo_IIA-like_dom.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR005742. TopoIV_A_Gneg.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 2 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiPARC_RICTY
AccessioniPrimary (citable) accession number: Q68XU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 11, 2004
Last modified: July 22, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.