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Q68XU1

- PARC_RICTY

UniProt

Q68XU1 - PARC_RICTY

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Protein

DNA topoisomerase 4 subunit A

Gene
parC, RT0065
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule By similarity.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei40 – 401Interaction with DNA By similarity
Sitei76 – 761Interaction with DNA By similarity
Sitei78 – 781Interaction with DNA By similarity
Sitei119 – 1191Transition state stabilizer By similarity
Active sitei120 – 1201O-(5'-phospho-DNA)-tyrosine intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. DNA binding Source: UniProtKB-HAMAP
  3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. chromosome segregation Source: UniProtKB-HAMAP
  2. DNA topological change Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Topoisomerase

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-68-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 4 subunit A (EC:5.99.1.3)
Alternative name(s):
Topoisomerase IV subunit A
Gene namesi
Name:parC
Ordered Locus Names:RT0065
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: InterPro
  2. extrinsic component of plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 737737DNA topoisomerase 4 subunit AUniRule annotationPRO_0000273115Add
BLAST

Interactioni

Subunit structurei

Heterotetramer composed of ParC and ParE By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0065.

Structurei

3D structure databases

ProteinModelPortaliQ68XU1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0188.
HOGENOMiHOG000076277.
KOiK02621.
OMAiWHQETGS.
OrthoDBiEOG661H5V.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_00936. ParC_type1.
InterProiIPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
IPR005742. TopoIV_A_Gneg.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 2 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68XU1-1 [UniParc]FASTAAdd to Basket

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MKEAKIENID FGNALSERYL AYALSTIMSR SLPDVRDGLK PVHRRLLYAM    50
LQLRLEPNSG YKKCARVVGD VIGKYHPHGD VAVYDTLVRL AQHFSLRYPL 100
IDGQGNFGSI DGDNAAAMRY TESRMTEICM LLMKDIDKDT VDFRSTYDDS 150
DLEPVIMPAS FPNLLANGSE GIAVGMATNI PPHNLHELCD ALLYLIDNPQ 200
AGVNDIMNFI KGPDFPTGGI IIDQTKVINA AYTTGRGSFR VRSRWEKEEL 250
SYGTYQIVVT EIPYQVQKSK LIEQIAILLK DKKIPLISSI RDESTDIIRL 300
VIEPRDRSCD PQIVMESLFK LTNLESRIQL NMNVIGSNNV PRVMNIVEIL 350
QEFLVHRQNI ITRRSTYLLN KIKQRLEILK VLKIVYLNLD EIIEIIRRED 400
EPKTIIMERF KISEIQVEVI LNTRLRALQK LEEHAIIDEH SNLQKQQAIL 450
EKILKNHKEL WKIVKKEIKS VQTQFGLNTI IGARRTSFEE VDLTNQVIDI 500
TAFITKEPIT IICSKMGWIR LLKGHNTDLS TIKYKEGDAE KFIIEAYTTD 550
KILIISSKGR FFTLLADNIS KGKGTAVSIK LLVDIGNNDI TNILVYKPYQ 600
LLLLASSIGK GFLVNSNEVI AQTKAGKQIM NIPEGYACIT CLPVNGNSIA 650
CINESRRLLI FNINEIPEMK KGQGVVLQRF KNAKLLDIKI FNKEDGLSWN 700
DGKKIQLEKN IVAFLGKRGS AGTLPPIGFP KNNRFSS 737
Length:737
Mass (Da):83,414
Last modified:October 11, 2004 - v1
Checksum:iCF736359974EBB90
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03551.1.
RefSeqiYP_067033.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03551; AAU03551; RT0065.
GeneIDi2958686.
KEGGirty:RT0065.
PATRICi17909288. VBIRicTyp34752_0065.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03551.1 .
RefSeqi YP_067033.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68XU1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0065.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03551 ; AAU03551 ; RT0065 .
GeneIDi 2958686.
KEGGi rty:RT0065.
PATRICi 17909288. VBIRicTyp34752_0065.

Phylogenomic databases

eggNOGi COG0188.
HOGENOMi HOG000076277.
KOi K02621.
OMAi WHQETGS.
OrthoDBi EOG661H5V.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-68-MONOMER.

Family and domain databases

Gene3Di 3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPi MF_00936. ParC_type1.
InterProi IPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
IPR005742. TopoIV_A_Gneg.
[Graphical view ]
Pfami PF03989. DNA_gyraseA_C. 2 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view ]
SMARTi SM00434. TOP4c. 1 hit.
[Graphical view ]
SUPFAMi SSF56719. SSF56719. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiPARC_RICTY
AccessioniPrimary (citable) accession number: Q68XU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi