Reviewed, UniProtKB/Swiss-Prot Q68XT9 (SYR_RICTY)

Names and origin

Protein names

Recommended name:
    Arginyl-tRNA synthetase
    EC=6.1.1.19
Alternative name(s):
    Arginine--tRNA ligase
      Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	RT0067

Organism

Rickettsia typhi [Complete proteome] [HAMAP]

Taxonomic identifier

785 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	576 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 576	576	Arginyl-tRNA synthetase HAMAP MF_00123		PRO_0000242085
Regions
	Motif	126 – 136	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q68XT9-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 006E9B38A061BD60	FASTA	576	65,090
	10 20 30 40 50 60 MNIFNQLKQD IIAASQQLYN NQEIANTATI ETPKDSFNGD LSSNIAMIIA SKESIAPREV 70 80 90 100 110 120 ALKFKEVLVT LPYIASIEIA GPGFINFTIK AESWQAAIKD ILQHEEKFFE IDIDKNSNIN 130 140 150 160 170 180 IEYVSANPTG PMHIGHARGA VYGDVLARIL QKVGYSVTKE YYVNDAGSQI NDLVSTVLLR 190 200 210 220 230 240 YKEALGEQIT IPIGLYPGEY LIPLGEILSK EYGNKLLTMN DVERFKIIKS LAVEKMLDLN 250 260 270 280 290 300 RKDLADLGIK HDIFFSEQSL YDKGEIEKTV KLLESMGLIY EGTLPAPKGK VHEDWKHKVQ 310 320 330 340 350 360 KLFKSTNYGD SQDRPIEKAD GSWSYFASDL AYAKDKIDRG ANHLIYVLGA DHSGYVKRIE 370 380 390 400 410 420 AIVKALGQEK VKVDVKICQL VNFVENGVPV KMSKRLGSFA SVQDVNKKVG KDIIRFMMLT 430 440 450 460 470 480 RQNDKPLDFD LVKVKEQSRE NPIFYVQYAH VRTKSILSKA RELMPEAYNS FKEGKYNLSL 490 500 510 520 530 540 LSTEEEIEII KLLAAWTKTL EASVKYFEPH RIAFYLINLA SKFHSMWNFG KENSDYRFII 550 560 570 ENNQELTLAR LALASVIQKV IASGLEVIGV EPMVTM

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017197 Genomic DNA. Translation: AAU03553.1.
RefSeq	YP_067035.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2959225.
GenomeReviews	Gene locus RT0067 in contig AE017197_GR.
KEGG	rty:RT0067.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q68XT9.
OMA	LGDCIAN
Enzyme and pathway databases
BioCyc	RTYP257363:RT0067-MON.
BRENDA	6.1.1.19. 281221.
Family and domain databases
HAMAP	MF_00123. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ic. IPR015945. Arg-tRNA-synth_Ic_core. IPR005148. Arg-tRNA-synth_Ic_N. IPR008909. DALR_anticod_bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM00836. DALR_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_RICTY

Accession

Primary (citable) accession number: Q68XT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	October 11, 2004
Last modified:	November 24, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)