Reviewed,
UniProtKB/Swiss-Prot Q68XT6 (KDSA_RICTY)
Last modified
December 15, 2009.
Version 36.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 2-dehydro-3-deoxyphosphooctonate aldolase EC=2.5.1.55 Alternative name(s): Phospho-2-dehydro-3-deoxyoctonate aldolase 3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase KDO-8-phosphate synthetase Short name=KDO 8-P synthase Short name=KDOPS | ||||
| Gene names |
| ||||
| Organism | Rickettsia typhi [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 785 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group |
Protein attributes
| Sequence length | 274 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP MF_00056 |
| Pathway | Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP MF_00056 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00056 |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the kdsA family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipopolysaccharide biosynthesis |
| Cellular component | Cytoplasm |
| Molecular function | Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 3-deoxy-8-phosphooctulonate synthase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 274 | 274 | 2-dehydro-3-deoxyphosphooctonate aldolase HAMAP MF_00056 | PRO_0000187161 | |||
Sequences
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References
| [1] | "Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. Weinstock G.M.J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington. |
Cross-references
Sequence databases | |
|---|---|
| AE017197 Genomic DNA. Translation: AAU03556.1. | |
| RefSeq | YP_067038.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2958710. |
| GenomeReviews | Gene locus RT0070 in contig AE017197_GR. |
| KEGG | rty:RT0070. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG575990. |
| OMA | LAPWDMG. |
Enzyme and pathway databases | |
| BioCyc | RTYP257363:RT0070-MON. |
| BRENDA | 2.5.1.55. 281221. |
Family and domain databases | |
| HAMAP | MF_00056. [Tree] |
| InterPro | IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006269. KDO8P_synthase. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| PANTHER | PTHR21057:SF2. KDO8P_synthase. 1 hit. |
| Pfam | PF00793. DAHP_synth_1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | KDSA_RICTY | ||||||||
| Accession | Primary (citable) accession number: Q68XT6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| Rickettsia typhi Rickettsia typhi (strain Wilmington): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


