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Reviewed, UniProtKB/Swiss-Prot Q68XT0 (MNMG_RICTY)

Last modified December 15, 2009. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    tRNA uridine 5-carboxymethylaminomethyl modification enzyme mnmG
Alternative name(s):
    Glucose-inhibited division protein A
Gene names
Name: mnmG
Synonyms: gidA
Ordered Locus Names: RT0076
OrganismRickettsia typhi [Complete proteome] [HAMAP]
Taxonomic identifier785 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

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Protein attributes

Sequence length621 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34 By similarity.

Cofactor

FAD By similarity.

Subunit structure

Homodimer By similarity. Heterotetramer of two mnmE and two mnmG subunits By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the mnmG family.

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Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
NAD
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtRNA wobble uridine modification

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionFAD binding

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 621621tRNA uridine 5-carboxymethylaminomethyl modification enzyme mnmG HAMAP MF_00129
PRO_0000117167

Regions

Nucleotide binding10 – 156FAD By similarity
Nucleotide binding269 – 28315NAD Potential

Sites

Binding site1221FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding site1771FAD By similarity
Binding site3661FAD By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q68XT0-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 5AC5B7DE978FD61C

FASTA62169,134
        10         20         30         40         50         60 
MLKYGVIIIG GGHAGVEAAA ASARLGVHTL LITLKPENLG EMSCNPAIGG IAKGTLVKEI 

        70         80         90        100        110        120 
DALDGLMGFV IDKAGIHYKM LNETRGPAVW GPRAQADRKL YKKVMYQILT NYRNLDILYG 

       130        140        150        160        170        180 
KVEDIQIKSS KVEAVILNNG IKIFCQKVVL TTGTFLSGFI HIGSMKIPAG RIYEEPSYGL 

       190        200        210        220        230        240 
SNTLKRLGFK IARLKTGTPP RIDGRTIDYS KTTLQQGDQI PRPFSELTDA IDVPQINCFI 

       250        260        270        280        290        300 
TKTTAETHDI IRENLDKSAM YSGQIKGIGP RYCPSIEDKI VKFSTKLEHR IFLEPEGLED 

       310        320        330        340        350        360 
YTIYPNGIST SLPKEIQYKL IKTIPGLENA QVLRPGYAIE YDYVDPREIN ITLETKKITG 

       370        380        390        400        410        420 
LYFAGQINGT TGYEEAAGQG IIAGINAALS VKDQEPFILT RATSYIGVMI DDLTTSGTVE 

       430        440        450        460        470        480 
PYRMFTSRSE YRLSLRADNA DLRLTELGIN IGVVTEKRKN IFTKKCNNIE KTKLLLNKLS 

       490        500        510        520        530        540 
LTTSKLAKIG IQVAQDGKYK TVLDLFKIPT FNVEQAIKIF PILRKQNNNI LQLLYIEAKY 

       550        560        570        580        590        600 
ASYLTRQYAD INLFQSEEIQ LIPKNIDYFK IPSISLEIQE KLSYHKPTTI GVARRISGIT 

       610        620 
PAAIMAIIIY LKTKYSDGSS K

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References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

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Cross-references

Sequence databases

AE017197 Genomic DNA. Translation: AAU03562.1.
RefSeqYP_067044.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2959195.
GenomeReviewsGene locus RT0076 in contig AE017197_GR.
KEGGrty:RT0076.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG284774.
OMAIQFRVLN.

Enzyme and pathway databases

BioCycRTYP257363:RT0076-MON.

Family and domain databases

HAMAPMF_00129.
[Tree]
InterProIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004416. GidA.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view]
PfamPF01134. GIDA. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
PROSITEPS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameMNMG_RICTY
AccessionPrimary (citable) accession number: Q68XT0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 11, 2004
Last modified: December 15, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents