Reviewed, UniProtKB/Swiss-Prot Q68XS7 (TLCA_RICTY)

Names and origin

Protein names

Recommended name:
    ADP,ATP carrier protein 1
Alternative name(s):
    ADP/ATP translocase 1

Gene names

Name:	tlcA
Synonyms:	tlc1
Ordered Locus Names:	RT0079

Organism

Rickettsia typhi [Complete proteome] [HAMAP]

Taxonomic identifier

785 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the ADP/ATP translocase tlc family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Nucleotide-binding
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP:ADP antiporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 498	498	ADP,ATP carrier protein 1		PRO_0000286468
Regions
	Topological domain	1 – 33	33	Cytoplasmic Probable
	Transmembrane	34 – 54	21	Probable
	Topological domain	55 – 67	13	Extracellular Probable
	Transmembrane	68 – 88	21	Probable
	Topological domain	89 – 92	4	Cytoplasmic Probable
	Transmembrane	93 – 113	21	Probable
	Topological domain	114 – 147	34	Extracellular Probable
	Transmembrane	148 – 168	21	Probable
	Topological domain	169 – 184	16	Cytoplasmic Probable
	Transmembrane	185 – 205	21	Probable
	Topological domain	206 – 218	13	Extracellular Probable
	Transmembrane	219 – 239	21	Probable
	Topological domain	240 – 279	40	Cytoplasmic Probable
	Transmembrane	280 – 300	21	Probable
	Topological domain	301 – 320	20	Extracellular Probable
	Transmembrane	321 – 341	21	Probable
	Topological domain	342 – 348	7	Cytoplasmic Probable
	Transmembrane	349 – 369	21	Probable
	Topological domain	370 – 379	10	Extracellular Probable
	Transmembrane	380 – 400	21	Probable
	Topological domain	401 – 438	38	Cytoplasmic Probable
	Transmembrane	439 – 459	21	Probable
	Topological domain	460 – 465	6	Extracellular Probable
	Transmembrane	466 – 486	21	Probable
	Topological domain	487 – 498	12	Cytoplasmic Probable
	Nucleotide binding	436 – 442	7	ATP Potential
Amino acid modifications
	Disulfide bond	37 ↔ 85		Probable

Sequences

	Sequence		Length	Mass (Da)
	Q68XS7-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 20C82BF035662AF6	FASTA	498	56,882
	10 20 30 40 50 60 MSTSKSENYL SELRKIIWPI EQHENKKFLP LAFMMFCILL NYSTLRSIKD GFVVTDIGTE 70 80 90 100 110 120 SISFLKTYIV LPSAVIAMVI YVKLCDILKQ ENIFYVITSF FLGYFALFAF VLYPYPDLVH 130 140 150 160 170 180 PDHKTIESLS LAYPNFKWFI KIVGKWSFAS FYTIAELWGT MMLSLLFWQF ANQITKITEA 190 200 210 220 230 240 KRFYSMFGLL ANLALPVTSV VIGYFLHEKT QIVSEHLKFI PLFVIMITSS FLIILTYRWM 250 260 270 280 290 300 NKNVLTDPRL YDPTLVKEKK AKAKLSFIES FKMIFTSKYV GYIALLIIAY GVSVNLVEGV 310 320 330 340 350 360 WKSKVKELYP TKEAYTIYMG QFQFYQGWVA IAFMLIGSNI LRKVSWLTAA MITPLMMFIT 370 380 390 400 410 420 GAAFFSFIFF DSVIAMNLTG ILASSPLTLA VMFGMIQNVL SKGVKYSLFD ATKNMAYIPL 430 440 450 460 470 480 DKDLRVKGQA AVEVIGGRLG KSGGAIIQST FFILFPAFGF IEATPYFASI FFIIVILWIF 490 AVKGLNKEYQ VLVNKNEN

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017197 Genomic DNA. Translation: AAU03565.1.
RefSeq	YP_067047.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2959196.
GenomeReviews	Gene locus RT0079 in contig AE017197_GR.
KEGG	rty:RT0079.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG586333.
OMA	AYPNFKW.
Enzyme and pathway databases
BioCyc	RTYP257363:RT0079-MON.
Family and domain databases
InterPro	IPR004667. ADP_ATP_car. [Graphical view]
Pfam	PF03219. TLC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TLCA_RICTY

Accession

Primary (citable) accession number: Q68XS7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	October 11, 2004
Last modified:	December 15, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)