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Q68XS5

- PGSA_RICTY

UniProt

Q68XS5 - PGSA_RICTY

Protein

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Gene

pgsA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    • Comment

    Functioni

    This protein catalyzes the committed step to the synthesis of the acidic phospholipids.By similarity

    Catalytic activityi

    CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. phosphatidylglycerol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-86-MONOMER.
    UniPathwayiUPA00084; UER00503.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC:2.7.8.5)
    Gene namesi
    Name:pgsA
    Ordered Locus Names:RT0081
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 178178CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferasePRO_0000281055Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi257363.RT0081.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei32 – 5221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0558.
    HOGENOMiHOG000010898.
    KOiK00995.
    OMAiETKMGAM.
    OrthoDBiEOG6WMJ3D.

    Family and domain databases

    InterProiIPR000462. CDP-OH_P_trans.
    IPR004570. Phosphatidylglycerol_P_synth.
    [Graphical view]
    PfamiPF01066. CDP-OH_P_transf. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000847. Phos_ph_gly_syn. 1 hit.
    TIGRFAMsiTIGR00560. pgsA. 1 hit.
    PROSITEiPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68XS5-1 [UniParc]FASTAAdd to Basket

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    MKNLPNYLTI ARIMVIPVII LLFYINNSLA RKLGALLFVL ASITDFFDGY    50
    IARKYNLVTS FGKMFDPIAD KLLVGCVTIM LLKKDNVDEI PCLLILAREF 100
    LVSGLREFLA LVKVSVPVSR LAKLKTFLQM FALSILILGS KGSGIIYLDI 150
    VGEIILWIAA FLTIITGYSY FKACKTYF 178
    Length:178
    Mass (Da):19,959
    Last modified:October 11, 2004 - v1
    Checksum:i8C08659AF6AD63BE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03567.1.
    RefSeqiYP_067049.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03567; AAU03567; RT0081.
    GeneIDi2959229.
    KEGGirty:RT0081.
    PATRICi17909330. VBIRicTyp34752_0086.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03567.1 .
    RefSeqi YP_067049.1. NC_006142.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0081.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03567 ; AAU03567 ; RT0081 .
    GeneIDi 2959229.
    KEGGi rty:RT0081.
    PATRICi 17909330. VBIRicTyp34752_0086.

    Phylogenomic databases

    eggNOGi COG0558.
    HOGENOMi HOG000010898.
    KOi K00995.
    OMAi ETKMGAM.
    OrthoDBi EOG6WMJ3D.

    Enzyme and pathway databases

    UniPathwayi UPA00084 ; UER00503 .
    BioCyci RTYP257363:GJEQ-86-MONOMER.

    Family and domain databases

    InterProi IPR000462. CDP-OH_P_trans.
    IPR004570. Phosphatidylglycerol_P_synth.
    [Graphical view ]
    Pfami PF01066. CDP-OH_P_transf. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000847. Phos_ph_gly_syn. 1 hit.
    TIGRFAMsi TIGR00560. pgsA. 1 hit.
    PROSITEi PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiPGSA_RICTY
    AccessioniPrimary (citable) accession number: Q68XS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3