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Q68XS5

- PGSA_RICTY

UniProt

Q68XS5 - PGSA_RICTY

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Protein

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Gene

pgsA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This protein catalyzes the committed step to the synthesis of the acidic phospholipids.By similarity

Catalytic activityi

CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. phosphatidylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-86-MONOMER.
UniPathwayiUPA00084; UER00503.

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC:2.7.8.5)
Gene namesi
Name:pgsA
Ordered Locus Names:RT0081
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence AnalysisAdd
BLAST
Transmembranei32 – 5221HelicalSequence AnalysisAdd
BLAST
Transmembranei61 – 8121HelicalSequence AnalysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferasePRO_0000281055Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0081.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0558.
HOGENOMiHOG000010898.
KOiK00995.
OMAiETKMGAM.
OrthoDBiEOG6WMJ3D.

Family and domain databases

InterProiIPR000462. CDP-OH_P_trans.
IPR004570. Phosphatidylglycerol_P_synth.
[Graphical view]
PfamiPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMsiTIGR00560. pgsA. 1 hit.
PROSITEiPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68XS5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNLPNYLTI ARIMVIPVII LLFYINNSLA RKLGALLFVL ASITDFFDGY
60 70 80 90 100
IARKYNLVTS FGKMFDPIAD KLLVGCVTIM LLKKDNVDEI PCLLILAREF
110 120 130 140 150
LVSGLREFLA LVKVSVPVSR LAKLKTFLQM FALSILILGS KGSGIIYLDI
160 170
VGEIILWIAA FLTIITGYSY FKACKTYF
Length:178
Mass (Da):19,959
Last modified:October 11, 2004 - v1
Checksum:i8C08659AF6AD63BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03567.1.
RefSeqiYP_067049.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03567; AAU03567; RT0081.
GeneIDi2959229.
KEGGirty:RT0081.
PATRICi17909330. VBIRicTyp34752_0086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03567.1 .
RefSeqi YP_067049.1. NC_006142.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0081.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03567 ; AAU03567 ; RT0081 .
GeneIDi 2959229.
KEGGi rty:RT0081.
PATRICi 17909330. VBIRicTyp34752_0086.

Phylogenomic databases

eggNOGi COG0558.
HOGENOMi HOG000010898.
KOi K00995.
OMAi ETKMGAM.
OrthoDBi EOG6WMJ3D.

Enzyme and pathway databases

UniPathwayi UPA00084 ; UER00503 .
BioCyci RTYP257363:GJEQ-86-MONOMER.

Family and domain databases

InterProi IPR000462. CDP-OH_P_trans.
IPR004570. Phosphatidylglycerol_P_synth.
[Graphical view ]
Pfami PF01066. CDP-OH_P_transf. 1 hit.
[Graphical view ]
PIRSFi PIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMsi TIGR00560. pgsA. 1 hit.
PROSITEi PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiPGSA_RICTY
AccessioniPrimary (citable) accession number: Q68XS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2004
Last modified: November 26, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3