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Q68XS5

- PGSA_RICTY

UniProt

Q68XS5 - PGSA_RICTY

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Protein

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Gene
pgsA, RT0081
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This protein catalyzes the committed step to the synthesis of the acidic phospholipids By similarity.

Catalytic activityi

CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. phosphatidylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-86-MONOMER.
UniPathwayiUPA00084; UER00503.

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC:2.7.8.5)
Gene namesi
Name:pgsA
Ordered Locus Names:RT0081
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521Helical; Reviewed predictionAdd
BLAST
Transmembranei32 – 5221Helical; Reviewed predictionAdd
BLAST
Transmembranei61 – 8121Helical; Reviewed predictionAdd
BLAST
Transmembranei145 – 16521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferasePRO_0000281055Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0081.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0558.
HOGENOMiHOG000010898.
KOiK00995.
OMAiETKMGAM.
OrthoDBiEOG6WMJ3D.

Family and domain databases

InterProiIPR000462. CDP-OH_P_trans.
IPR004570. Phosphatidylglycerol_P_synth.
[Graphical view]
PfamiPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMsiTIGR00560. pgsA. 1 hit.
PROSITEiPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68XS5-1 [UniParc]FASTAAdd to Basket

« Hide

MKNLPNYLTI ARIMVIPVII LLFYINNSLA RKLGALLFVL ASITDFFDGY    50
IARKYNLVTS FGKMFDPIAD KLLVGCVTIM LLKKDNVDEI PCLLILAREF 100
LVSGLREFLA LVKVSVPVSR LAKLKTFLQM FALSILILGS KGSGIIYLDI 150
VGEIILWIAA FLTIITGYSY FKACKTYF 178
Length:178
Mass (Da):19,959
Last modified:October 11, 2004 - v1
Checksum:i8C08659AF6AD63BE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03567.1.
RefSeqiYP_067049.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03567; AAU03567; RT0081.
GeneIDi2959229.
KEGGirty:RT0081.
PATRICi17909330. VBIRicTyp34752_0086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03567.1 .
RefSeqi YP_067049.1. NC_006142.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0081.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03567 ; AAU03567 ; RT0081 .
GeneIDi 2959229.
KEGGi rty:RT0081.
PATRICi 17909330. VBIRicTyp34752_0086.

Phylogenomic databases

eggNOGi COG0558.
HOGENOMi HOG000010898.
KOi K00995.
OMAi ETKMGAM.
OrthoDBi EOG6WMJ3D.

Enzyme and pathway databases

UniPathwayi UPA00084 ; UER00503 .
BioCyci RTYP257363:GJEQ-86-MONOMER.

Family and domain databases

InterProi IPR000462. CDP-OH_P_trans.
IPR004570. Phosphatidylglycerol_P_synth.
[Graphical view ]
Pfami PF01066. CDP-OH_P_transf. 1 hit.
[Graphical view ]
PIRSFi PIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMsi TIGR00560. pgsA. 1 hit.
PROSITEi PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiPGSA_RICTY
AccessioniPrimary (citable) accession number: Q68XS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi