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Protein

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Gene

pgsA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein catalyzes the committed step to the synthesis of the acidic phospholipids.By similarity

Catalytic activityi

CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. phosphatidylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-86-MONOMER.
UniPathwayiUPA00084; UER00503.

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC:2.7.8.5)
Gene namesi
Name:pgsA
Ordered Locus Names:RT0081
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604 Componenti: Chromosome

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence AnalysisAdd
BLAST
Transmembranei32 – 5221HelicalSequence AnalysisAdd
BLAST
Transmembranei61 – 8121HelicalSequence AnalysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferasePRO_0000281055Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0081.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0558.
HOGENOMiHOG000010898.
KOiK00995.
OMAiFAAVTDW.
OrthoDBiEOG6WMJ3D.

Family and domain databases

InterProiIPR000462. CDP-OH_P_trans.
IPR004570. Phosphatidylglycerol_P_synth.
[Graphical view]
PfamiPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMsiTIGR00560. pgsA. 1 hit.
PROSITEiPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68XS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNLPNYLTI ARIMVIPVII LLFYINNSLA RKLGALLFVL ASITDFFDGY
60 70 80 90 100
IARKYNLVTS FGKMFDPIAD KLLVGCVTIM LLKKDNVDEI PCLLILAREF
110 120 130 140 150
LVSGLREFLA LVKVSVPVSR LAKLKTFLQM FALSILILGS KGSGIIYLDI
160 170
VGEIILWIAA FLTIITGYSY FKACKTYF
Length:178
Mass (Da):19,959
Last modified:October 10, 2004 - v1
Checksum:i8C08659AF6AD63BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03567.1.
RefSeqiWP_011190554.1. NC_006142.1.
YP_067049.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03567; AAU03567; RT0081.
GeneIDi2959229.
KEGGirty:RT0081.
PATRICi17909330. VBIRicTyp34752_0086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03567.1.
RefSeqiWP_011190554.1. NC_006142.1.
YP_067049.1. NC_006142.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0081.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU03567; AAU03567; RT0081.
GeneIDi2959229.
KEGGirty:RT0081.
PATRICi17909330. VBIRicTyp34752_0086.

Phylogenomic databases

eggNOGiCOG0558.
HOGENOMiHOG000010898.
KOiK00995.
OMAiFAAVTDW.
OrthoDBiEOG6WMJ3D.

Enzyme and pathway databases

UniPathwayiUPA00084; UER00503.
BioCyciRTYP257363:GJEQ-86-MONOMER.

Family and domain databases

InterProiIPR000462. CDP-OH_P_trans.
IPR004570. Phosphatidylglycerol_P_synth.
[Graphical view]
PfamiPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMsiTIGR00560. pgsA. 1 hit.
PROSITEiPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiPGSA_RICTY
AccessioniPrimary (citable) accession number: Q68XS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 19, 2007
Last sequence update: October 10, 2004
Last modified: March 31, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.