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Q68XS5 (PGSA_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

EC=2.7.8.5
Gene names
Name:pgsA
Ordered Locus Names:RT0081
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein catalyzes the committed step to the synthesis of the acidic phospholipids By similarity.

Catalytic activity

CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.

Pathway

Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 178178CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
PRO_0000281055

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane32 – 5221Helical; Potential
Transmembrane61 – 8121Helical; Potential
Transmembrane145 – 16521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q68XS5 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 8C08659AF6AD63BE

FASTA17819,959
        10         20         30         40         50         60 
MKNLPNYLTI ARIMVIPVII LLFYINNSLA RKLGALLFVL ASITDFFDGY IARKYNLVTS 

        70         80         90        100        110        120 
FGKMFDPIAD KLLVGCVTIM LLKKDNVDEI PCLLILAREF LVSGLREFLA LVKVSVPVSR 

       130        140        150        160        170 
LAKLKTFLQM FALSILILGS KGSGIIYLDI VGEIILWIAA FLTIITGYSY FKACKTYF 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU03567.1.
RefSeqYP_067049.1. NC_006142.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0081.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU03567; AAU03567; RT0081.
GeneID2959229.
KEGGrty:RT0081.
PATRIC17909330. VBIRicTyp34752_0086.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0558.
HOGENOMHOG000010898.
KOK00995.
OMAQMVAIPF.
OrthoDBEOG6WMJ3D.
ProtClustDBCLSK870720.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-86-MONOMER.
UniPathwayUPA00084; UER00503.

Family and domain databases

InterProIPR000462. CDP-OH_P_trans.
IPR004570. Phosphatidylglycerol_P_synth.
[Graphical view]
PfamPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFPIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMsTIGR00560. pgsA. 1 hit.
PROSITEPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGSA_RICTY
AccessionPrimary (citable) accession number: Q68XS5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2004
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways