Q68XS4 (YIDC_RICTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membrane protein insertase YidC

Alternative name(s):
Foldase YidC
Membrane integrase YidC
Membrane protein YidC

Gene names

Name:	yidC
Ordered Locus Names:	RT0082

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	558 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins By similarity.
Subunit structure	Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01810.
Sequence similarities	Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein insertion into membrane Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 558	558	Membrane protein insertase YidC		PRO_0000272372
Regions
	Transmembrane	5 – 25	21	Helical; Potential
	Transmembrane	332 – 352	21	Helical; Potential
	Transmembrane	355 – 375	21	Helical; Potential
	Transmembrane	429 – 449	21	Helical; Potential
	Transmembrane	474 – 494	21	Helical; Potential
	Transmembrane	520 – 540	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q68XS4 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 5E7852D533135342	FASTA	558	63,987
	10 20 30 40 50 60 MNNNIINLIA AIVLSLSIIF GWQYFVIKPE QKKQQQRMAI YKSENLKKQK ALAEHTSNIT 70 80 90 100 110 120 VQEAGQVQRI KIESESLTGS IALKGLRFDD LILKKYKQDL SQNSPAVRLF SPANTENAYF 130 140 150 160 170 180 AEIGLVSNLS SVKLPNSNTV WNSDSEVLSP EKPVNLFWVN EDGIKFLVTI TVDKNYLFTI 190 200 210 220 230 240 EQTIINNSDK ELPVQAYGLI NRKYIAVEKA VNILHQGPIG CIDENLKEYS YDDIKDQKSA 250 260 270 280 290 300 KFALSKVDWI GIADKYWLSS LIPDKSSSYS ANFNYALKQG AERYQVDFIS PVQVIKPGKN 310 320 330 340 350 360 LSIKSRIFAG AKKVDLLDEY EKSYDIKLFD RAIDFGWFYI ITKPVFYAMN FFYGYVGNFG 370 380 390 400 410 420 VSILIVTVII KLLMFTLANK SYRSMKKMKN LQPEIDRIKN LYNNDKARLN QEIMALYKKS 430 440 450 460 470 480 KVNPVAGCLP ILVQIPVFFS IYKVLYVTIE MRHAPFYGWI KDLSSPDPTT IFNLFGLLPF 490 500 510 520 530 540 APPSFLMIGA WPILMAITMF LHQKMSPELA DPIQAQVMKF MPLIFLFMFS SFPVGLLIYW 550 SWNNILSIIQ QYYINKFN

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU03568.1.
RefSeq	YP_067050.1. NC_006142.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2959214.
GenomeReviews	Gene locus RT0082 in contig AE017197_GR.
KEGG	rty:RT0082.
PATRIC	17909332. VBIRicTyp34752_0087.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG507812.
OMA	FVTIEMR.
ProtClustDB	PRK01318.
Enzyme and pathway databases
BioCyc	RTYP257363:RT0082-MONOMER.
Family and domain databases
HAMAP	MF_01810. YidC_type1. [Tree]
InterPro	IPR019998. Membr_insert_OxaA/YidC_bac. IPR001708. Membrane_insertion_OxaA/YidC. [Graphical view]
KO	K03217.
PANTHER	PTHR12428. Innermemb_insert. 1 hit.
Pfam	PF02096. 60KD_IMP. 1 hit. [Graphical view]
PRINTS	PR00701. 60KDINNERMP. PR01900. YIDCPROTEIN.
TIGRFAMs	TIGR03593. YidC_nterm. 1 hit. TIGR03592. YidC_oxa1_C. 1 hit.
ProtoNet	Search...

Entry information

Entry name

YIDC_RICTY

Accession

Primary (citable) accession number: Q68XS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program