Reviewed, UniProtKB/Swiss-Prot Q68XS4 (OXAA_RICTY)

Names and origin

Protein names

Recommended name:
    Inner membrane protein oxaA

Gene names

Name:	oxaA
Ordered Locus Names:	RT0082

Organism

Rickettsia typhi [Complete proteome] [HAMAP]

Taxonomic identifier

785 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	558 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Required for the insertion of integral membrane proteins into the membrane. Probably plays an essential role in the integration of proteins of the respiratory chain complexes. Involved in integration of membrane proteins that insert dependently and independently of the Sec translocase complex By similarity.
Subunit structure	Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the OXA1/oxaA family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein insertion into membrane Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 558	558	Inner membrane protein oxaA HAMAP MF_01810		PRO_0000272372
Regions
	Transmembrane	5 – 25	21	Potential
	Transmembrane	332 – 352	21	Potential
	Transmembrane	355 – 375	21	Potential
	Transmembrane	429 – 449	21	Potential
	Transmembrane	474 – 494	21	Potential
	Transmembrane	520 – 540	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q68XS4-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 5E7852D533135342	FASTA	558	63,987
	10 20 30 40 50 60 MNNNIINLIA AIVLSLSIIF GWQYFVIKPE QKKQQQRMAI YKSENLKKQK ALAEHTSNIT 70 80 90 100 110 120 VQEAGQVQRI KIESESLTGS IALKGLRFDD LILKKYKQDL SQNSPAVRLF SPANTENAYF 130 140 150 160 170 180 AEIGLVSNLS SVKLPNSNTV WNSDSEVLSP EKPVNLFWVN EDGIKFLVTI TVDKNYLFTI 190 200 210 220 230 240 EQTIINNSDK ELPVQAYGLI NRKYIAVEKA VNILHQGPIG CIDENLKEYS YDDIKDQKSA 250 260 270 280 290 300 KFALSKVDWI GIADKYWLSS LIPDKSSSYS ANFNYALKQG AERYQVDFIS PVQVIKPGKN 310 320 330 340 350 360 LSIKSRIFAG AKKVDLLDEY EKSYDIKLFD RAIDFGWFYI ITKPVFYAMN FFYGYVGNFG 370 380 390 400 410 420 VSILIVTVII KLLMFTLANK SYRSMKKMKN LQPEIDRIKN LYNNDKARLN QEIMALYKKS 430 440 450 460 470 480 KVNPVAGCLP ILVQIPVFFS IYKVLYVTIE MRHAPFYGWI KDLSSPDPTT IFNLFGLLPF 490 500 510 520 530 540 APPSFLMIGA WPILMAITMF LHQKMSPELA DPIQAQVMKF MPLIFLFMFS SFPVGLLIYW 550 SWNNILSIIQ QYYINKFN

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017197 Genomic DNA. Translation: AAU03568.1.
RefSeq	YP_067050.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2959214.
GenomeReviews	Gene locus RT0082 in contig AE017197_GR.
KEGG	rty:RT0082.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG507812.
OMA	FVTIEMR.
Enzyme and pathway databases
BioCyc	RTYP257363:RT0082-MON.
Family and domain databases
HAMAP	MF_01810. [Tree]
InterPro	IPR020001. Membrane_insert_OxaA/YidC_core. IPR001708. Membrane_insertion_OxaA/YidC. IPR013308. Membrane_insertion_YidC. IPR019998. Membrane_insertion_YidC/OxoA_N. [Graphical view]
PANTHER	PTHR12428. Innermemb_insert. 1 hit.
Pfam	PF02096. 60KD_IMP. 1 hit. [Graphical view]
PRINTS	PR00701. 60KDINNERMP. PR01900. YIDCPROTEIN.
ProtoNet	Search...

Entry information

Entry name

OXAA_RICTY

Accession

Primary (citable) accession number: Q68XS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	October 11, 2004
Last modified:	December 15, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)