Reviewed, UniProtKB/Swiss-Prot Q68XS0 (DHSB_RICTY)

Names and origin

Protein names

Recommended name:
    Succinate dehydrogenase iron-sulfur subunit
    EC=1.3.99.1

Gene names

Name:	sdhB
Ordered Locus Names:	RT0086

Organism

Rickettsia typhi [Complete proteome] [HAMAP]

Taxonomic identifier

785 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Succinate + acceptor = fumarate + reduced acceptor.
Cofactor	Binds 1 2Fe-2S cluster. Binds 1 3Fe-4S cluster. Binds 1 4Fe-4S cluster.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.
Subunit structure	Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and an hydrophobic anchor protein.
Sequence similarities	Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. Contains 1 2Fe-2S ferredoxin-type domain. Contains 1 4Fe-4S ferredoxin-type domain.

Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Ligand	2Fe-2S 3Fe-4S 4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW 3 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW succinate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Succinate dehydrogenase iron-sulfur subunit		PRO_0000280984
Regions
	Domain	28 – 119	92	2Fe-2S ferredoxin-type
	Domain	161 – 191	31	4Fe-4S ferredoxin-type
Sites
	Metal binding	80	1	Iron-sulfur 1 (2Fe-2S) By similarity
	Metal binding	85	1	Iron-sulfur 1 (2Fe-2S) By similarity
	Metal binding	88	1	Iron-sulfur 1 (2Fe-2S) By similarity
	Metal binding	100	1	Iron-sulfur 1 (2Fe-2S) By similarity
	Metal binding	171	1	Iron-sulfur 2 (4Fe-4S) By similarity
	Metal binding	174	1	Iron-sulfur 2 (4Fe-4S) By similarity
	Metal binding	177	1	Iron-sulfur 2 (4Fe-4S) By similarity
	Metal binding	181	1	Iron-sulfur 3 (3Fe-4S) By similarity
	Metal binding	228	1	Iron-sulfur 3 (3Fe-4S) By similarity
	Metal binding	234	1	Iron-sulfur 3 (3Fe-4S) By similarity
	Metal binding	238	1	Iron-sulfur 2 (4Fe-4S) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q68XS0-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: F9CBCE4066008131	FASTA	261	29,601
	10 20 30 40 50 60 MVELRLPSNS VVKKGRVHKA QQEMLKPRKV QVYRYDPDLN KNPTIDSFEI DLSKTGPMVL 70 80 90 100 110 120 DALIKIKNEI DSTLTFRRSC REGICGSCAM NIDGTNTLAC IKPIEDISGD IKIYPLPHMK 130 140 150 160 170 180 VVKDLVPDMS HFYTQYESIE PWLKNDNPAP SNSERLQSIQ DREKLDGLYE CILCACCSTS 190 200 210 220 230 240 CPSYWWNSDK YLGPAILLQA YRWIADSRDD NTGARLEALE DPFKLYRCHT IMNCTKTCPK 250 260 GLNPAKAIGR VKSLIAERHG V

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU03572.1.
RefSeq	YP_067054.1.
3D structure databases
HSSP	HSSP built from PDB template 1YQ3 based on UniProtKB Q9YHT2.
SMR	Q68XS0. Positions 28-256.
ModBase	Search...
Genome annotation databases
GeneID	2959191.
GenomeReviews	Gene locus RT0086 in contig AE017197_GR.
KEGG	rty:RT0086.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG616382.
OMA	SLIAERH.
Enzyme and pathway databases
BioCyc	RTYP257363:RT0086-MONOMER.
BRENDA	1.3.99.1. 281221.
Family and domain databases
InterPro	IPR006058. 2Fe2S_fd_BS. IPR017896. 4Fe4S_Fe-S-bd. IPR017900. 4Fe4S_Fe_S_CS. IPR012675. b-grasp_ferredoxin-like. IPR001041. Ferredoxin. IPR012285. Fum_reductase_C. IPR009051. Helical_ferredxn. IPR004489. Succ_DH/fum_Rdtase_Fe-S. [Graphical view]
Gene3D	G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit. G3DSA:1.10.1060.10. Fum_reductase_C. 1 hit.
TIGRFAMs	TIGR00384. dhsB. 1 hit.
PROSITE	PS00197. 2FE2S_FER_1. 1 hit. PS51085. 2FE2S_FER_2. 1 hit. PS00198. 4FE4S_FER_1. 1 hit. PS51379. 4FE4S_FER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHSB_RICTY

Accession

Primary (citable) accession number: Q68XS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	October 11, 2004
Last modified:	February 9, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)