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Q68XS0

- SDHB_RICTY

UniProt

Q68XS0 - SDHB_RICTY

Protein

Succinate dehydrogenase iron-sulfur subunit

Gene

sdhB

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    Binds 1 2Fe-2S cluster.
    Binds 1 3Fe-4S cluster.
    Binds 1 4Fe-4S cluster.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi80 – 801Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi85 – 851Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi100 – 1001Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi171 – 1711Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi174 – 1741Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi177 – 1771Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi181 – 1811Iron-sulfur 3 (3Fe-4S)By similarity
    Binding sitei186 – 1861Ubiquinone; shared with SdhD subunitBy similarity
    Metal bindingi228 – 2281Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi234 – 2341Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi238 – 2381Iron-sulfur 2 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    4. electron carrier activity Source: InterPro
    5. metal ion binding Source: UniProtKB-KW
    6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-91-MONOMER.
    UniPathwayiUPA00223; UER01005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase iron-sulfur subunit (EC:1.3.5.1)
    Gene namesi
    Name:sdhB
    Ordered Locus Names:RT0086
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Succinate dehydrogenase iron-sulfur subunitPRO_0000280984Add
    BLAST

    Interactioni

    Subunit structurei

    Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

    Protein-protein interaction databases

    STRINGi257363.RT0086.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68XS0.
    SMRiQ68XS0. Positions 28-256.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 119922Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini161 – 191314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0479.
    HOGENOMiHOG000160590.
    KOiK00240.
    OMAiSEPHWES.
    OrthoDBiEOG6CK7MG.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view]
    PfamiPF13085. Fer2_3. 1 hit.
    PF13183. Fer4_8. 1 hit.
    [Graphical view]
    SUPFAMiSSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR00384. dhsB. 1 hit.
    PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68XS0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVELRLPSNS VVKKGRVHKA QQEMLKPRKV QVYRYDPDLN KNPTIDSFEI    50
    DLSKTGPMVL DALIKIKNEI DSTLTFRRSC REGICGSCAM NIDGTNTLAC 100
    IKPIEDISGD IKIYPLPHMK VVKDLVPDMS HFYTQYESIE PWLKNDNPAP 150
    SNSERLQSIQ DREKLDGLYE CILCACCSTS CPSYWWNSDK YLGPAILLQA 200
    YRWIADSRDD NTGARLEALE DPFKLYRCHT IMNCTKTCPK GLNPAKAIGR 250
    VKSLIAERHG V 261
    Length:261
    Mass (Da):29,601
    Last modified:October 11, 2004 - v1
    Checksum:iF9CBCE4066008131
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03572.1.
    RefSeqiYP_067054.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03572; AAU03572; RT0086.
    GeneIDi2959191.
    KEGGirty:RT0086.
    PATRICi17909340. VBIRicTyp34752_0091.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03572.1 .
    RefSeqi YP_067054.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68XS0.
    SMRi Q68XS0. Positions 28-256.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0086.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03572 ; AAU03572 ; RT0086 .
    GeneIDi 2959191.
    KEGGi rty:RT0086.
    PATRICi 17909340. VBIRicTyp34752_0091.

    Phylogenomic databases

    eggNOGi COG0479.
    HOGENOMi HOG000160590.
    KOi K00240.
    OMAi SEPHWES.
    OrthoDBi EOG6CK7MG.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01005 .
    BioCyci RTYP257363:GJEQ-91-MONOMER.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view ]
    Pfami PF13085. Fer2_3. 1 hit.
    PF13183. Fer4_8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR00384. dhsB. 1 hit.
    PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiSDHB_RICTY
    AccessioniPrimary (citable) accession number: Q68XS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3