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Protein

ATP-dependent zinc metalloprotease FtsH

Gene

ftsH

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi417Zinc; catalyticUniRule annotation1
Active sitei418UniRule annotation1
Metal bindingi421Zinc; catalyticUniRule annotation1
Metal bindingi495Zinc; catalyticUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi195 – 202ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciRTYP257363:G1G0L-90-MONOMER

Protein family/group databases

MEROPSiM41.001

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent zinc metalloprotease FtsHUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:ftsHUniRule annotation
Ordered Locus Names:RT0087
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000000604 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicUniRule annotation6
Transmembranei7 – 27HelicalUniRule annotationAdd BLAST21
Topological domaini28 – 103PeriplasmicUniRule annotationAdd BLAST76
Transmembranei104 – 124HelicalUniRule annotationAdd BLAST21
Topological domaini125 – 637CytoplasmicUniRule annotationAdd BLAST513

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002723371 – 637ATP-dependent zinc metalloprotease FtsHAdd BLAST637

Proteomic databases

PRIDEiQ68XR9

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0087

Structurei

3D structure databases

ProteinModelPortaliQ68XR9
SMRiQ68XR9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the central section; belongs to the AAA ATPase family.UniRule annotation
In the C-terminal section; belongs to the peptidase M41 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C3H Bacteria
COG0465 LUCA
HOGENOMiHOG000217277
KOiK03798
OMAiMNKRWRN
OrthoDBiPOG091H02HH

Family and domain databases

HAMAPiMF_01458 FtsH, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR005936 FtsH
IPR027417 P-loop_NTPase
IPR011546 Pept_M41_FtsH_extracell
IPR000642 Peptidase_M41
IPR037219 Peptidase_M41-like
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF06480 FtsH_ext, 1 hit
PF01434 Peptidase_M41, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF140990 SSF140990, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01241 FtsH_fam, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

Q68XR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNQGRSILA WAALFIFVIL LFNVFQSDGL LGVRNNITFS DFLTRVDERT
60 70 80 90 100
INSVKIQGRV IEGTSNDGST FSTYSPDYPD LVNRLTSNDV NIEVVPLETR
110 120 130 140 150
MNTFLGFLIS WFPMLLLIGV WVFFMRQMHG GGKAMGFGKS KARLLSDKGP
160 170 180 190 200
KITFKDVAGI DEAKEELTEI VDFLRDPSKF QKLGGKIPKG CLLIGPPGTG
210 220 230 240 250
KTLLAKAIAG EANVPFFSIS GSDFVEMFVG VGASRVRDMF EQGKRNAPCI
260 270 280 290 300
IFIDEIDAVG RHRGIGMGGG NDEREQTLNQ MLVEMDGFEA NEGVVIIAAT
310 320 330 340 350
NRPDVLDRAL LRPGRFDRQI AVANPDINGR EQILKVHLKK IKYNSTVLAR
360 370 380 390 400
IIARGTPGFS GAELANLVNE AALIAARLGK KEVDMHDMEE AKDKVLMGVV
410 420 430 440 450
RRSIAMSEKE KRLTAYHEGG HALVGLYCPA ASPIHKATII PRGNALGMVQ
460 470 480 490 500
RLPETDEYSQ NREQMESSIA VYMAGRVAEE IIFGKNKVTS GAASDIKGAT
510 520 530 540 550
NIARAMVTKA GLSDLIGPIF HGSSSDDMYG RQQSNEISEA TAKLIDAEVK
560 570 580 590 600
KIITQGYEFA KDILTKHIDQ LHTLANALIE YETLSGQQIK NLLSGRALDS
610 620 630
EEENKFPFND AHTIKIDKEK LHEKTKTTKA QKENIAS
Length:637
Mass (Da):69,979
Last modified:October 11, 2004 - v1
Checksum:i8EF54EB66B97BBBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA Translation: AAU03573.1
RefSeqiWP_011190560.1, NC_006142.1

Genome annotation databases

EnsemblBacteriaiAAU03573; AAU03573; RT0087
KEGGirty:RT0087

Similar proteinsi

Entry informationi

Entry nameiFTSH_RICTY
AccessioniPrimary (citable) accession number: Q68XR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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