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Q68XR9 (FTSH_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent zinc metalloprotease FtsH

EC=3.4.24.-
Gene names
Name:ftsH
Ordered Locus Names:RT0087
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length637 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins By similarity. HAMAP-Rule MF_01458

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01458

Subunit structure

Homohexamer Potential.

Subcellular location

Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side By similarity HAMAP-Rule MF_01458.

Sequence similarities

In the central section; belongs to the AAA ATPase family.

In the C-terminal section; belongs to the peptidase M41 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 637637ATP-dependent zinc metalloprotease FtsH HAMAP-Rule MF_01458
PRO_0000272337

Regions

Topological domain1 – 66Cytoplasmic Potential
Transmembrane7 – 2721Helical; Potential
Topological domain28 – 10376Periplasmic Potential
Transmembrane104 – 12421Helical; Potential
Topological domain125 – 637513Cytoplasmic Potential
Nucleotide binding195 – 2028ATP Potential

Sites

Active site4181 By similarity
Metal binding4171Zinc; catalytic By similarity
Metal binding4211Zinc; catalytic By similarity
Metal binding4951Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68XR9 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 8EF54EB66B97BBBB

FASTA63769,979
        10         20         30         40         50         60 
MNNQGRSILA WAALFIFVIL LFNVFQSDGL LGVRNNITFS DFLTRVDERT INSVKIQGRV 

        70         80         90        100        110        120 
IEGTSNDGST FSTYSPDYPD LVNRLTSNDV NIEVVPLETR MNTFLGFLIS WFPMLLLIGV 

       130        140        150        160        170        180 
WVFFMRQMHG GGKAMGFGKS KARLLSDKGP KITFKDVAGI DEAKEELTEI VDFLRDPSKF 

       190        200        210        220        230        240 
QKLGGKIPKG CLLIGPPGTG KTLLAKAIAG EANVPFFSIS GSDFVEMFVG VGASRVRDMF 

       250        260        270        280        290        300 
EQGKRNAPCI IFIDEIDAVG RHRGIGMGGG NDEREQTLNQ MLVEMDGFEA NEGVVIIAAT 

       310        320        330        340        350        360 
NRPDVLDRAL LRPGRFDRQI AVANPDINGR EQILKVHLKK IKYNSTVLAR IIARGTPGFS 

       370        380        390        400        410        420 
GAELANLVNE AALIAARLGK KEVDMHDMEE AKDKVLMGVV RRSIAMSEKE KRLTAYHEGG 

       430        440        450        460        470        480 
HALVGLYCPA ASPIHKATII PRGNALGMVQ RLPETDEYSQ NREQMESSIA VYMAGRVAEE 

       490        500        510        520        530        540 
IIFGKNKVTS GAASDIKGAT NIARAMVTKA GLSDLIGPIF HGSSSDDMYG RQQSNEISEA 

       550        560        570        580        590        600 
TAKLIDAEVK KIITQGYEFA KDILTKHIDQ LHTLANALIE YETLSGQQIK NLLSGRALDS 

       610        620        630 
EEENKFPFND AHTIKIDKEK LHEKTKTTKA QKENIAS 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU03573.1.
RefSeqYP_067055.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68XR9.
SMRQ68XR9. Positions 144-399.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0087.

Protein family/group databases

MEROPSM41.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU03573; AAU03573; RT0087.
GeneID2959346.
KEGGrty:RT0087.
PATRIC17909342. VBIRicTyp34752_0092.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0465.
HOGENOMHOG000217277.
KOK03798.
OMAHKNYSEA.
OrthoDBEOG6PKFBJ.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-92-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_01458. FtsH.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01241. FtsH_fam. 1 hit.
PROSITEPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTSH_RICTY
AccessionPrimary (citable) accession number: Q68XR9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

Peptidase families

Classification of peptidase families and list of entries