ATP-dependent zinc metalloprotease FtsH - Rickettsia typhi (strain ATCC VR-144 / Wilmington)

Preferred order of sections

Names and origin

Protein names

Recommended name:
ATP-dependent zinc metalloprotease FtsH
EC=3.4.24.-

Gene names

Name:	ftsH
Ordered Locus Names:	RT0087

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group ›

Protein attributes

Sequence length	637 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins By similarity. HAMAP-Rule MF_01458
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homohexamer Potential.
Subcellular location	Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side By similarity HAMAP-Rule MF_01458.
Sequence similarities	In the central section; belongs to the AAA ATPase family. In the C-terminal section; belongs to the peptidase M41 family.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC protein catabolic process Inferred from electronic annotation. Source: HAMAP proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP ATPase activity Inferred from electronic annotation. Source: HAMAP metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 637

637

ATP-dependent zinc metalloprotease FtsH HAMAP-Rule MF_01458

PRO_0000272337

Regions

Topological domain

1 – 6

6

Cytoplasmic Potential

Transmembrane

7 – 27

21

Helical; Potential

Topological domain

28 – 103

76

Periplasmic Potential

Transmembrane

104 – 124

21

Helical; Potential

Topological domain

125 – 637

513

Cytoplasmic Potential

Nucleotide binding

195 – 202

8

ATP Potential

Sites

Active site

418

1

By similarity

Metal binding

417

1

Zinc; catalytic By similarity

Metal binding

421

1

Zinc; catalytic By similarity

Metal binding

495

1

Zinc; catalytic By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q68XR9 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 8EF54EB66B97BBBB
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FASTA

637

69,979

        10         20         30         40         50         60 
MNNQGRSILA WAALFIFVIL LFNVFQSDGL LGVRNNITFS DFLTRVDERT INSVKIQGRV 

        70         80         90        100        110        120 
IEGTSNDGST FSTYSPDYPD LVNRLTSNDV NIEVVPLETR MNTFLGFLIS WFPMLLLIGV 

       130        140        150        160        170        180 
WVFFMRQMHG GGKAMGFGKS KARLLSDKGP KITFKDVAGI DEAKEELTEI VDFLRDPSKF 

       190        200        210        220        230        240 
QKLGGKIPKG CLLIGPPGTG KTLLAKAIAG EANVPFFSIS GSDFVEMFVG VGASRVRDMF 

       250        260        270        280        290        300 
EQGKRNAPCI IFIDEIDAVG RHRGIGMGGG NDEREQTLNQ MLVEMDGFEA NEGVVIIAAT 

       310        320        330        340        350        360 
NRPDVLDRAL LRPGRFDRQI AVANPDINGR EQILKVHLKK IKYNSTVLAR IIARGTPGFS 

       370        380        390        400        410        420 
GAELANLVNE AALIAARLGK KEVDMHDMEE AKDKVLMGVV RRSIAMSEKE KRLTAYHEGG 

       430        440        450        460        470        480 
HALVGLYCPA ASPIHKATII PRGNALGMVQ RLPETDEYSQ NREQMESSIA VYMAGRVAEE 

       490        500        510        520        530        540 
IIFGKNKVTS GAASDIKGAT NIARAMVTKA GLSDLIGPIF HGSSSDDMYG RQQSNEISEA 

       550        560        570        580        590        600 
TAKLIDAEVK KIITQGYEFA KDILTKHIDQ LHTLANALIE YETLSGQQIK NLLSGRALDS 

       610        620        630 
EEENKFPFND AHTIKIDKEK LHEKTKTTKA QKENIAS

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References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A.

Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU03573.1.
RefSeq	YP_067055.1. NC_006142.1.
3D structure databases
HSSP	HSSP built from PDB template 2CE7 based on UniProtKB Q9WZ49.
ProteinModelPortal	Q68XR9.
SMR	Q68XR9. Positions 144-399.
ModBase	Search...
Protein-protein interaction databases
STRING	257363.RT0087.
Protein family/group databases
MEROPS	M41.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAU03573; AAU03573; RT0087.
GeneID	2959346.
KEGG	rty:RT0087.
PATRIC	17909342. VBIRicTyp34752_0092.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0465.
HOGENOM	HOG000217277.
KO	K03798.
OMA	STYSPDY.
ProtClustDB	CLSK870717.
Enzyme and pathway databases
BioCyc	RTYP257363:GJEQ-92-MONOMER.
Family and domain databases
HAMAP	MF_01458. FtsH.
InterPro	IPR003593. AAA+_ATPase. IPR003959. ATPase_AAA_core. IPR003960. ATPase_AAA_CS. IPR005936. FtsH. IPR011546. Pept_M41_FtsH_extracell. IPR000642. Peptidase_M41. [Graphical view]
Pfam	PF00004. AAA. 1 hit. PF06480. FtsH_ext. 1 hit. PF01434. Peptidase_M41. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01241. FtsH_fam. 1 hit.
PROSITE	PS00674. AAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTSH_RICTY

Accession

Primary (citable) accession number: Q68XR9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents