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Q68XR9

- FTSH_RICTY

UniProt

Q68XR9 - FTSH_RICTY

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Protein

ATP-dependent zinc metalloprotease FtsH

Gene
ftsH, RT0087
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins By similarity.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi417 – 4171Zinc; catalytic By similarity
Active sitei418 – 4181 By similarity
Metal bindingi421 – 4211Zinc; catalytic By similarity
Metal bindingi495 – 4951Zinc; catalytic By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi195 – 2028ATP Reviewed prediction

GO - Molecular functioni

  1. ATPase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP
  3. metalloendopeptidase activity Source: InterPro
  4. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-92-MONOMER.

Protein family/group databases

MEROPSiM41.001.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent zinc metalloprotease FtsH (EC:3.4.24.-)
Gene namesi
Name:ftsH
Ordered Locus Names:RT0087
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66Cytoplasmic Reviewed prediction
Transmembranei7 – 2721Helical; Reviewed predictionAdd
BLAST
Topological domaini28 – 10376Periplasmic Reviewed predictionAdd
BLAST
Transmembranei104 – 12421Helical; Reviewed predictionAdd
BLAST
Topological domaini125 – 637513Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 637637ATP-dependent zinc metalloprotease FtsHUniRule annotationPRO_0000272337Add
BLAST

Interactioni

Subunit structurei

Homohexamer Reviewed prediction.

Protein-protein interaction databases

STRINGi257363.RT0087.

Structurei

3D structure databases

ProteinModelPortaliQ68XR9.
SMRiQ68XR9. Positions 144-399.

Family & Domainsi

Sequence similaritiesi

In the central section; belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0465.
HOGENOMiHOG000217277.
KOiK03798.
OMAiHKNYSEA.
OrthoDBiEOG6PKFBJ.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01458. FtsH.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68XR9-1 [UniParc]FASTAAdd to Basket

« Hide

MNNQGRSILA WAALFIFVIL LFNVFQSDGL LGVRNNITFS DFLTRVDERT    50
INSVKIQGRV IEGTSNDGST FSTYSPDYPD LVNRLTSNDV NIEVVPLETR 100
MNTFLGFLIS WFPMLLLIGV WVFFMRQMHG GGKAMGFGKS KARLLSDKGP 150
KITFKDVAGI DEAKEELTEI VDFLRDPSKF QKLGGKIPKG CLLIGPPGTG 200
KTLLAKAIAG EANVPFFSIS GSDFVEMFVG VGASRVRDMF EQGKRNAPCI 250
IFIDEIDAVG RHRGIGMGGG NDEREQTLNQ MLVEMDGFEA NEGVVIIAAT 300
NRPDVLDRAL LRPGRFDRQI AVANPDINGR EQILKVHLKK IKYNSTVLAR 350
IIARGTPGFS GAELANLVNE AALIAARLGK KEVDMHDMEE AKDKVLMGVV 400
RRSIAMSEKE KRLTAYHEGG HALVGLYCPA ASPIHKATII PRGNALGMVQ 450
RLPETDEYSQ NREQMESSIA VYMAGRVAEE IIFGKNKVTS GAASDIKGAT 500
NIARAMVTKA GLSDLIGPIF HGSSSDDMYG RQQSNEISEA TAKLIDAEVK 550
KIITQGYEFA KDILTKHIDQ LHTLANALIE YETLSGQQIK NLLSGRALDS 600
EEENKFPFND AHTIKIDKEK LHEKTKTTKA QKENIAS 637
Length:637
Mass (Da):69,979
Last modified:October 11, 2004 - v1
Checksum:i8EF54EB66B97BBBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03573.1.
RefSeqiYP_067055.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03573; AAU03573; RT0087.
GeneIDi2959346.
KEGGirty:RT0087.
PATRICi17909342. VBIRicTyp34752_0092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03573.1 .
RefSeqi YP_067055.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68XR9.
SMRi Q68XR9. Positions 144-399.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0087.

Protein family/group databases

MEROPSi M41.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03573 ; AAU03573 ; RT0087 .
GeneIDi 2959346.
KEGGi rty:RT0087.
PATRICi 17909342. VBIRicTyp34752_0092.

Phylogenomic databases

eggNOGi COG0465.
HOGENOMi HOG000217277.
KOi K03798.
OMAi HKNYSEA.
OrthoDBi EOG6PKFBJ.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-92-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_01458. FtsH.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view ]
Pfami PF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01241. FtsH_fam. 1 hit.
PROSITEi PS00674. AAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiFTSH_RICTY
AccessioniPrimary (citable) accession number: Q68XR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi