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Protein

ATP-dependent zinc metalloprotease FtsH

Gene

ftsH

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi417 – 4171Zinc; catalyticUniRule annotation
Active sitei418 – 4181UniRule annotation
Metal bindingi421 – 4211Zinc; catalyticUniRule annotation
Metal bindingi495 – 4951Zinc; catalyticUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi195 – 2028ATPUniRule annotation

GO - Molecular functioni

  1. ATPase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP
  3. metalloendopeptidase activity Source: InterPro
  4. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-92-MONOMER.

Protein family/group databases

MEROPSiM41.001.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent zinc metalloprotease FtsHUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:ftsHUniRule annotation
Ordered Locus Names:RT0087
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicUniRule annotation
Transmembranei7 – 2721HelicalUniRule annotationAdd
BLAST
Topological domaini28 – 10376PeriplasmicUniRule annotationAdd
BLAST
Transmembranei104 – 12421HelicalUniRule annotationAdd
BLAST
Topological domaini125 – 637513CytoplasmicUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 637637ATP-dependent zinc metalloprotease FtsHPRO_0000272337Add
BLAST

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0087.

Structurei

3D structure databases

ProteinModelPortaliQ68XR9.
SMRiQ68XR9. Positions 144-399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the central section; belongs to the AAA ATPase family.UniRule annotation
In the C-terminal section; belongs to the peptidase M41 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0465.
HOGENOMiHOG000217277.
KOiK03798.
OMAiAGGYVIM.
OrthoDBiEOG6PKFBJ.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01458. FtsH.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68XR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNQGRSILA WAALFIFVIL LFNVFQSDGL LGVRNNITFS DFLTRVDERT
60 70 80 90 100
INSVKIQGRV IEGTSNDGST FSTYSPDYPD LVNRLTSNDV NIEVVPLETR
110 120 130 140 150
MNTFLGFLIS WFPMLLLIGV WVFFMRQMHG GGKAMGFGKS KARLLSDKGP
160 170 180 190 200
KITFKDVAGI DEAKEELTEI VDFLRDPSKF QKLGGKIPKG CLLIGPPGTG
210 220 230 240 250
KTLLAKAIAG EANVPFFSIS GSDFVEMFVG VGASRVRDMF EQGKRNAPCI
260 270 280 290 300
IFIDEIDAVG RHRGIGMGGG NDEREQTLNQ MLVEMDGFEA NEGVVIIAAT
310 320 330 340 350
NRPDVLDRAL LRPGRFDRQI AVANPDINGR EQILKVHLKK IKYNSTVLAR
360 370 380 390 400
IIARGTPGFS GAELANLVNE AALIAARLGK KEVDMHDMEE AKDKVLMGVV
410 420 430 440 450
RRSIAMSEKE KRLTAYHEGG HALVGLYCPA ASPIHKATII PRGNALGMVQ
460 470 480 490 500
RLPETDEYSQ NREQMESSIA VYMAGRVAEE IIFGKNKVTS GAASDIKGAT
510 520 530 540 550
NIARAMVTKA GLSDLIGPIF HGSSSDDMYG RQQSNEISEA TAKLIDAEVK
560 570 580 590 600
KIITQGYEFA KDILTKHIDQ LHTLANALIE YETLSGQQIK NLLSGRALDS
610 620 630
EEENKFPFND AHTIKIDKEK LHEKTKTTKA QKENIAS
Length:637
Mass (Da):69,979
Last modified:October 11, 2004 - v1
Checksum:i8EF54EB66B97BBBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03573.1.
RefSeqiYP_067055.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03573; AAU03573; RT0087.
GeneIDi2959346.
KEGGirty:RT0087.
PATRICi17909342. VBIRicTyp34752_0092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03573.1.
RefSeqiYP_067055.1. NC_006142.1.

3D structure databases

ProteinModelPortaliQ68XR9.
SMRiQ68XR9. Positions 144-399.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0087.

Protein family/group databases

MEROPSiM41.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU03573; AAU03573; RT0087.
GeneIDi2959346.
KEGGirty:RT0087.
PATRICi17909342. VBIRicTyp34752_0092.

Phylogenomic databases

eggNOGiCOG0465.
HOGENOMiHOG000217277.
KOiK03798.
OMAiAGGYVIM.
OrthoDBiEOG6PKFBJ.

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-92-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01458. FtsH.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiFTSH_RICTY
AccessioniPrimary (citable) accession number: Q68XR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 11, 2004
Last modified: January 7, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.