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Q68XR9

- FTSH_RICTY

UniProt

Q68XR9 - FTSH_RICTY

Protein

ATP-dependent zinc metalloprotease FtsH

Gene

ftsH

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi417 – 4171Zinc; catalyticUniRule annotation
    Active sitei418 – 4181UniRule annotation
    Metal bindingi421 – 4211Zinc; catalyticUniRule annotation
    Metal bindingi495 – 4951Zinc; catalyticUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi195 – 2028ATPUniRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP
    3. metalloendopeptidase activity Source: InterPro
    4. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. protein catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-92-MONOMER.

    Protein family/group databases

    MEROPSiM41.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent zinc metalloprotease FtsHUniRule annotation (EC:3.4.24.-UniRule annotation)
    Gene namesi
    Name:ftsHUniRule annotation
    Ordered Locus Names:RT0087
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 637637ATP-dependent zinc metalloprotease FtsHPRO_0000272337Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer.UniRule annotation

    Protein-protein interaction databases

    STRINGi257363.RT0087.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68XR9.
    SMRiQ68XR9. Positions 144-399.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66CytoplasmicUniRule annotation
    Topological domaini28 – 10376PeriplasmicUniRule annotationAdd
    BLAST
    Topological domaini125 – 637513CytoplasmicUniRule annotationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalUniRule annotationAdd
    BLAST
    Transmembranei104 – 12421HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    In the central section; belongs to the AAA ATPase family.UniRule annotation
    In the C-terminal section; belongs to the peptidase M41 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0465.
    HOGENOMiHOG000217277.
    KOiK03798.
    OMAiHKNYSEA.
    OrthoDBiEOG6PKFBJ.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_01458. FtsH.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR005936. FtsH.
    IPR027417. P-loop_NTPase.
    IPR011546. Pept_M41_FtsH_extracell.
    IPR000642. Peptidase_M41.
    [Graphical view]
    PfamiPF00004. AAA. 1 hit.
    PF06480. FtsH_ext. 1 hit.
    PF01434. Peptidase_M41. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
    PROSITEiPS00674. AAA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68XR9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNQGRSILA WAALFIFVIL LFNVFQSDGL LGVRNNITFS DFLTRVDERT    50
    INSVKIQGRV IEGTSNDGST FSTYSPDYPD LVNRLTSNDV NIEVVPLETR 100
    MNTFLGFLIS WFPMLLLIGV WVFFMRQMHG GGKAMGFGKS KARLLSDKGP 150
    KITFKDVAGI DEAKEELTEI VDFLRDPSKF QKLGGKIPKG CLLIGPPGTG 200
    KTLLAKAIAG EANVPFFSIS GSDFVEMFVG VGASRVRDMF EQGKRNAPCI 250
    IFIDEIDAVG RHRGIGMGGG NDEREQTLNQ MLVEMDGFEA NEGVVIIAAT 300
    NRPDVLDRAL LRPGRFDRQI AVANPDINGR EQILKVHLKK IKYNSTVLAR 350
    IIARGTPGFS GAELANLVNE AALIAARLGK KEVDMHDMEE AKDKVLMGVV 400
    RRSIAMSEKE KRLTAYHEGG HALVGLYCPA ASPIHKATII PRGNALGMVQ 450
    RLPETDEYSQ NREQMESSIA VYMAGRVAEE IIFGKNKVTS GAASDIKGAT 500
    NIARAMVTKA GLSDLIGPIF HGSSSDDMYG RQQSNEISEA TAKLIDAEVK 550
    KIITQGYEFA KDILTKHIDQ LHTLANALIE YETLSGQQIK NLLSGRALDS 600
    EEENKFPFND AHTIKIDKEK LHEKTKTTKA QKENIAS 637
    Length:637
    Mass (Da):69,979
    Last modified:October 11, 2004 - v1
    Checksum:i8EF54EB66B97BBBB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03573.1.
    RefSeqiYP_067055.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03573; AAU03573; RT0087.
    GeneIDi2959346.
    KEGGirty:RT0087.
    PATRICi17909342. VBIRicTyp34752_0092.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03573.1 .
    RefSeqi YP_067055.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68XR9.
    SMRi Q68XR9. Positions 144-399.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0087.

    Protein family/group databases

    MEROPSi M41.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03573 ; AAU03573 ; RT0087 .
    GeneIDi 2959346.
    KEGGi rty:RT0087.
    PATRICi 17909342. VBIRicTyp34752_0092.

    Phylogenomic databases

    eggNOGi COG0465.
    HOGENOMi HOG000217277.
    KOi K03798.
    OMAi HKNYSEA.
    OrthoDBi EOG6PKFBJ.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-92-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_01458. FtsH.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR005936. FtsH.
    IPR027417. P-loop_NTPase.
    IPR011546. Pept_M41_FtsH_extracell.
    IPR000642. Peptidase_M41.
    [Graphical view ]
    Pfami PF00004. AAA. 1 hit.
    PF06480. FtsH_ext. 1 hit.
    PF01434. Peptidase_M41. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01241. FtsH_fam. 1 hit.
    PROSITEi PS00674. AAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiFTSH_RICTY
    AccessioniPrimary (citable) accession number: Q68XR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3