Reviewed, UniProtKB/Swiss-Prot Q68XR3 (GCP_RICTY)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	RT0093

Organism

Rickettsia typhi [Complete proteome] [HAMAP]

Taxonomic identifier

785 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 387	387	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000303525
Sites
	Metal binding	112	1	Zinc Potential
	Metal binding	116	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	Q68XR3-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: E29017BB64063847	FASTA	387	42,546
	10 20 30 40 50 60 MKKILGIESS CDDTAISIIT ESRKILSNII IPQNTEHAVF GGVVPEIAAR SHLSNLDQAL 70 80 90 100 110 120 ENVLTKSNTE LTEISAIAAT SGPGLIGGVI VGSMFARSLS SALNKPFIAI NHLEGHALTV 130 140 150 160 170 180 RLTDNISYPY LLLLASGGHC QFVAVLGLGK YKILGSTIDD AIGETFDKVA KMLNLSFPGG 190 200 210 220 230 240 PEIEKRAKLG NPHKYKFPKP IINSGNCNMS FSGLKTAVRN LIMSLKEVND SVINDIAASF 250 260 270 280 290 300 QFTIGAILSS KMLNAIRLYQ QILNYYYENV DYTTNLNLKS FRQDEFNLNH LQDITRPKSR 310 320 330 340 350 360 IYLQNSFRSN LLNDTIVIAG GVAANKYLQE ILSNCTQTYG YRLIAPPMHL CTDNAAMIAY 370 380 AGLERYNNKL FSPLNFCPKA KWSLEDI

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017197 Genomic DNA. Translation: AAU03579.1.
RefSeq	YP_067061.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	2959131.
GenomeReviews	Gene locus RT0093 in contig AE017197_GR.
KEGG	rty:RT0093.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG304663.
OMA	RNCNFSF.
Enzyme and pathway databases
BioCyc	RTYP257363:RT0093-MON.
BRENDA	3.4.24.57. 281221.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_O-sialoglycoprot. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 2 hits. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_RICTY

Accession

Primary (citable) accession number: Q68XR3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	October 11, 2004
Last modified:	December 15, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)