Reviewed, UniProtKB/Swiss-Prot Q68XQ3 (DSB_RICTY)

Names and origin

Protein names

Recommended name:
    Putative protein-disulfide oxidoreductase RT0103
    EC=1.8.-.-

Gene names

Ordered Locus Names:

RT0103

Organism

Rickettsia typhi [Complete proteome] [HAMAP]

Taxonomic identifier

785 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	May be required for disulfide bond formation in some proteins By similarity.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the thioredoxin family. DsbA subfamily. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
Molecular function	Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 270	253	Putative protein-disulfide oxidoreductase RT0103		PRO_0000259992
Regions
	Domain	71 – 264	194	Thioredoxin
Amino acid modifications
	Disulfide bond	117 ↔ 120		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	Q68XQ3-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 5FAC9AB7B8A9E403	FASTA	270	30,708
	10 20 30 40 50 60 MKNIFIVLIF LFLSSCAEVK AQDKQHEEQQ IIEQEPLQNN ETPQEANQES INSANTAKSV 70 80 90 100 110 120 LHNHDNNQTE SVLTQDLHEQ KKTAITTKVT FKIDNNDMVL GNKKSNVIVV EYFSPTCPHC 130 140 150 160 170 180 AYYHQTIFPA LKKKYIDTNK IAYVVREFIA TKQDLDAAIL ARCKGDINSF IQFHNIILQQ 190 200 210 220 230 240 QDKWAYSNKY RELLTDIGQL GGISPEEYKQ CLNSDKITET LIANTNLVAK APKFIGTPSF 250 260 270 FVNGVQTENY SIDNISRAVD RALEDETKSK

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017197 Genomic DNA. Translation: AAU03589.1.
RefSeq	YP_067071.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2958732.
GenomeReviews	Gene locus RT0103 in contig AE017197_GR.
KEGG	rty:RT0103.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q68XQ3.
OMA	TLIANTN
Enzyme and pathway databases
BioCyc	RTYP257363:RT0103-MON.
Family and domain databases
InterPro	IPR017936. Thioredoxin-like. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSB_RICTY

Accession

Primary (citable) accession number: Q68XQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	October 11, 2004
Last modified:	November 24, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)