Q68XQ1 (ATP6_RICTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP synthase subunit a

Alternative name(s):
ATP synthase F0 sector subunit a
F-ATPase subunit 6

Gene names

Name:	atpB
Ordered Locus Names:	RT0105

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia typhi

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane By similarity. HAMAP-Rule MF_01393
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01393.
Sequence similarities	Belongs to the ATPase A chain family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(0) Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	plasma membrane ATP synthesis coupled proton transport Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proton-transporting ATP synthase complex, coupling factor F(o) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	proton-transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	ATP synthase subunit a HAMAP-Rule MF_01393		PRO_0000288665
Regions
	Transmembrane	29 – 49	21	Helical; Potential
	Transmembrane	84 – 104	21	Helical; Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Transmembrane	140 – 160	21	Helical; Potential
	Transmembrane	181 – 201	21	Helical; Potential
	Transmembrane	203 – 223	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q68XQ1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 27307E1D15EF4A4D	FASTA	242	27,320
	10 20 30 40 50 60 MTNSPLIQFN IKKLIDIKMF GLDVSFTNSS IYMLLASTLA LTYFYLAFYN RKLIPSRLQV 70 80 90 100 110 120 SAEIVYNFVV DMLNQNIGIK GRKFIPLVFS LFIFILFCNL LGMTPYSFTA TSHIIVTFTL 130 140 150 160 170 180 ALLIFLTVTI VGFIKHGMSF LTLFLPQGTP VWLAPLMIVI ELFTYLAKPV SLSLRLAANM 190 200 210 220 230 240 MAGHVLLKVI AGFTVSLMIY LKFLPIPLIV ILIGFEIFVA ILQAYIFTIL SCMYLNDAIN LH

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU03591.1.
RefSeq	YP_067073.1. NC_006142.1.
3D structure databases
ProteinModelPortal	Q68XQ1.
ModBase	Search...
Protein-protein interaction databases
STRING	257363.RT0105.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAU03591; AAU03591; RT0105.
GeneID	2959177.
KEGG	rty:RT0105.
PATRIC	17909382. VBIRicTyp34752_0112.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0356.
HOGENOM	HOG000253874.
KO	K02108.
OMA	FLPIPLM.
ProtClustDB	PRK05815.
Enzyme and pathway databases
BioCyc	RTYP257363:GJEQ-113-MONOMER.
Family and domain databases
Gene3D	1.20.120.220. 1 hit.
HAMAP	MF_01393. ATP_synth_a_bact.
InterPro	IPR000568. ATPase_F0-cplx_asu. IPR023011. ATPase_F0-cplx_asu_AS. [Graphical view]
PANTHER	PTHR11410. PTHR11410. 1 hit.
Pfam	PF00119. ATP-synt_A. 1 hit. [Graphical view]
PRINTS	PR00123. ATPASEA.
SUPFAM	SSF81336. ATPase_F0_A. 1 hit.
TIGRFAMs	TIGR01131. ATP_synt_6_or_A. 1 hit.
PROSITE	PS00449. ATPASE_A. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATP6_RICTY

Accession

Primary (citable) accession number: Q68XQ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program