Reviewed, UniProtKB/Swiss-Prot Q68XQ1 (ATP6_RICTY)

Names and origin

Protein names

Recommended name:
    ATP synthase subunit a
Alternative name(s):
    F-ATPase subunit 6
    ATP synthase F0 sector subunit a

Gene names

Name:	atpB
Ordered Locus Names:	RT0105

Organism

Rickettsia typhi [Complete proteome] [HAMAP]

Taxonomic identifier

785 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane By similarity.
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the ATPase A chain family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(0) Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	plasma membrane ATP synthesis coupled proton transport Inferred from electronic annotation. Source: HAMAP
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW proton-transporting ATP synthase complex, coupling factor F(o) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	hydrogen ion transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	ATP synthase subunit a HAMAP MF_01393		PRO_0000288665
Regions
	Transmembrane	29 – 49	21	Potential
	Transmembrane	84 – 104	21	Potential
	Transmembrane	114 – 134	21	Potential
	Transmembrane	140 – 160	21	Potential
	Transmembrane	181 – 201	21	Potential
	Transmembrane	203 – 223	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q68XQ1-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 27307E1D15EF4A4D	FASTA	242	27,320
	10 20 30 40 50 60 MTNSPLIQFN IKKLIDIKMF GLDVSFTNSS IYMLLASTLA LTYFYLAFYN RKLIPSRLQV 70 80 90 100 110 120 SAEIVYNFVV DMLNQNIGIK GRKFIPLVFS LFIFILFCNL LGMTPYSFTA TSHIIVTFTL 130 140 150 160 170 180 ALLIFLTVTI VGFIKHGMSF LTLFLPQGTP VWLAPLMIVI ELFTYLAKPV SLSLRLAANM 190 200 210 220 230 240 MAGHVLLKVI AGFTVSLMIY LKFLPIPLIV ILIGFEIFVA ILQAYIFTIL SCMYLNDAIN LH

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017197 Genomic DNA. Translation: AAU03591.1.
RefSeq	YP_067073.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2959177.
GenomeReviews	Gene locus RT0105 in contig AE017197_GR.
KEGG	rty:RT0105.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q68XQ1.
OMA	AFYNRKL
Enzyme and pathway databases
BioCyc	RTYP257363:RT0105-MON.
BRENDA	3.6.3.14. 281221.
Family and domain databases
HAMAP	MF_01393. [Tree]
InterPro	IPR000568. ATPase_F0-cplx_asu. [Graphical view]
Gene3D	G3DSA:1.20.120.220. ATPase_F0_A. 1 hit.
PANTHER	PTHR11410. ATPase_F0_A. 1 hit.
Pfam	PF00119. ATP-synt_A. 1 hit. [Graphical view]
PRINTS	PR00123. ATPASEA.
TIGRFAMs	TIGR01131. ATP_synt_6_or_A. 1 hit.
PROSITE	PS00449. ATPASE_A. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATP6_RICTY

Accession

Primary (citable) accession number: Q68XQ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	October 11, 2004
Last modified:	November 24, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)