Q68XP0 (DHSD_RICTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Succinate dehydrogenase hydrophobic membrane anchor subunit

Gene names

Name:	sdhD
Ordered Locus Names:	RT0116

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Membrane-anchoring subunit of succinate dehydrogenase (SDH) By similarity.
Cofactor	Heme group. The heme is bound between the two transmembrane subunits By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle.
Subunit structure	Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, sdhC and sdhD By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein.

Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro succinate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 125	125	Succinate dehydrogenase hydrophobic membrane anchor subunit		PRO_0000280981
Regions
	Topological domain	1 – 24	24	Cytoplasmic By similarity
	Transmembrane	25 – 45	21	Helical; By similarity
	Topological domain	46 – 67	22	Periplasmic By similarity
	Transmembrane	68 – 89	22	Helical; By similarity
	Topological domain	90 – 99	10	Cytoplasmic By similarity
	Transmembrane	100 – 123	24	Helical; By similarity
Sites
	Metal binding	80	1	Iron (heme axial ligand); shared with second transmembrane subunit By similarity
	Binding site	92	1	Ubiquinone By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q68XP0 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: E706A13E55B89704	FASTA	125	14,523
	10 20 30 40 50 60 MIYDFKAEII KSKSSSSSKS GAHHWLLQRV TGVVLALCSF WLIYFMFTNK NNDINIIMWE 70 80 90 100 110 120 FKKPFNIVIL LITVTISLYH SVLGMRVVIE DYINCHKLRN TLIIIVKLFC ILTIVAFIVA IFYSE

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU03602.1.
RefSeq	YP_067084.1. NC_006142.1.
3D structure databases
ProteinModelPortal	Q68XP0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2958800.
GenomeReviews	Gene locus RT0116 in contig AE017197_GR.
KEGG	rty:RT0116.
PATRIC	17909404. VBIRicTyp34752_0123.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG664078.
OMA	INIIMWE.
ProtClustDB	CLSK870758.
Enzyme and pathway databases
BioCyc	RTYP257363:RT0116-MONOMER.
Family and domain databases
InterPro	IPR014312. Succ_DH_anchor. IPR000701. Succ_DH_Fumarate_Rdtase_TM-su. [Graphical view]
KO	K00242.
Pfam	PF01127. Sdh_cyt. 1 hit. [Graphical view]
TIGRFAMs	TIGR02968. Succ_dehyd_anc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DHSD_RICTY

Accession

Primary (citable) accession number: Q68XP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program