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Q68XN9 (SDHA_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase flavoprotein subunit

EC=1.3.5.1
Gene names
Name:sdhA
Ordered Locus Names:RT0117
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length596 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

FAD.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.

Subunit structure

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

Subcellular location

Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity.

Sequence similarities

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 596596Succinate dehydrogenase flavoprotein subunit
PRO_0000280978

Regions

Nucleotide binding18 – 236FAD By similarity
Nucleotide binding41 – 5616FAD By similarity
Nucleotide binding407 – 4082FAD By similarity

Sites

Active site2901Proton acceptor By similarity
Binding site2251FAD By similarity
Binding site2461Substrate By similarity
Binding site2581Substrate By similarity
Binding site3571Substrate By similarity
Binding site3911FAD By similarity
Binding site4021Substrate By similarity

Amino acid modifications

Modified residue491Tele-8alpha-FAD histidine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68XN9 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 5B4F534F1490ECE1

FASTA59665,743
        10         20         30         40         50         60 
MTKAYNIIHH KFDVVVVGAG GAGLRSAFGM AKEGLNTACI TKIFPTRSHT VAAQGGISAA 

        70         80         90        100        110        120 
LGNMGEDDWR WHMYDTVKGS DWLGDQDAIE YMCKNAPDAI LELEHYGVPF SRTEDGKIYQ 

       130        140        150        160        170        180 
RPFGGMTTEY GKGKAAQRTC AAADRTGHAI LHTLYQQSLK HKVQFFIEYF AIDLLMEDGE 

       190        200        210        220        230        240 
CRGVVAWNLD DGSLHCFRAH NVVLATGGYG RAYFSATSAH TCTGDGGGMV IRAGLPLQDM 

       250        260        270        280        290        300 
EFVQFHPTGI YSAGCLITEG ARGEGGYLVN ANGERFMERY APAAKDLASR DVVSRAMTIE 

       310        320        330        340        350        360 
IREGRGVGEY KDHVFLHLNH LSPEILHRRL PGISETAKIF AGVDVTKDPI PVLPTVHYNM 

       370        380        390        400        410        420 
GGIPTNYHGQ VIIKDGKNHN SIVNGIMAIG EAACVSVHGA NRLGSNSLLD LVVFGRSSAL 

       430        440        450        460        470        480 
KAAELIKPVS PHKPLKKEIL EKIINRFDKI RHANGNVLVA DLRLQMQRTM QSHVSVFRTQ 

       490        500        510        520        530        540 
ELLDEGARMI SEIRNRYKDI KINDKSLIWN SDLVEALELD NLLDQALVTV YSAAARKESR 

       550        560        570        580        590 
GAHAREDYPD RNDIDWIKHT LSSIDDSGQI ILDYKPVTLT TLTDEISTIP PVKRIY 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU03603.1.
RefSeqYP_067085.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68XN9.
SMRQ68XN9. Positions 5-596.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0117.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU03603; AAU03603; RT0117.
GeneID2959329.
KEGGrty:RT0117.
PATRIC17909406. VBIRicTyp34752_0124.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1053.
HOGENOMHOG000160475.
KOK00239.
OMACQGVVCW.
OrthoDBEOG6M3PC4.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-125-MONOMER.
UniPathwayUPA00223; UER01005.

Family and domain databases

Gene3D1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHA_RICTY
AccessionPrimary (citable) accession number: Q68XN9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways