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Reviewed, UniProtKB/Swiss-Prot Q68XN9 (DHSA_RICTY)

Last modified November 25, 2008. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Succinate dehydrogenase flavoprotein subunit
    EC=1.3.99.1
Gene names
Name: sdhA
Ordered Locus Names: RT0117
OrganismRickettsia typhi [Complete proteome] [HAMAP]
Taxonomic identifier785 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length596 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Succinate + acceptor = fumarate + reduced acceptor.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle.

Subunit structure

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and an hydrophobic anchor protein.

Subcellular location

Cell inner membrane; Peripheral membrane protein; Cytoplasmic sideBy similarity.

Sequence similarities

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 596596Succinate dehydrogenase flavoprotein subunit
PRO_0000280978

Regions

Nucleotide binding41 – 5616FAD By similarity

Sites

Active site2901Proton acceptor By similarity
Binding site2461Substrate By similarity
Binding site2581Substrate By similarity
Binding site3571Substrate By similarity
Binding site4021Substrate By similarity

Amino acid modifications

Modified residue491Tele-8alpha-FAD histidine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68XN9-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 5B4F534F1490ECE1

FASTA59665,743
        10         20         30         40         50         60 
MTKAYNIIHH KFDVVVVGAG GAGLRSAFGM AKEGLNTACI TKIFPTRSHT VAAQGGISAA 

        70         80         90        100        110        120 
LGNMGEDDWR WHMYDTVKGS DWLGDQDAIE YMCKNAPDAI LELEHYGVPF SRTEDGKIYQ 

       130        140        150        160        170        180 
RPFGGMTTEY GKGKAAQRTC AAADRTGHAI LHTLYQQSLK HKVQFFIEYF AIDLLMEDGE 

       190        200        210        220        230        240 
CRGVVAWNLD DGSLHCFRAH NVVLATGGYG RAYFSATSAH TCTGDGGGMV IRAGLPLQDM 

       250        260        270        280        290        300 
EFVQFHPTGI YSAGCLITEG ARGEGGYLVN ANGERFMERY APAAKDLASR DVVSRAMTIE 

       310        320        330        340        350        360 
IREGRGVGEY KDHVFLHLNH LSPEILHRRL PGISETAKIF AGVDVTKDPI PVLPTVHYNM 

       370        380        390        400        410        420 
GGIPTNYHGQ VIIKDGKNHN SIVNGIMAIG EAACVSVHGA NRLGSNSLLD LVVFGRSSAL 

       430        440        450        460        470        480 
KAAELIKPVS PHKPLKKEIL EKIINRFDKI RHANGNVLVA DLRLQMQRTM QSHVSVFRTQ 

       490        500        510        520        530        540 
ELLDEGARMI SEIRNRYKDI KINDKSLIWN SDLVEALELD NLLDQALVTV YSAAARKESR 

       550        560        570        580        590 
GAHAREDYPD RNDIDWIKHT LSSIDDSGQI ILDYKPVTLT TLTDEISTIP PVKRIY 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

AE017197 Genomic DNA. Translation: AAU03603.1.
RefSeqYP_067085.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2959329.
GenomeReviewsGene locus RT0117 in contig AE017197_GR.
KEGGrty:RT0117.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ68XN9.

Enzyme and pathway databases

BioCycRTYP257363:RT0117-MON.

Family and domain databases

InterProIPR003953. FAD_bind2_N.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR003952. FRD_SDH_FAD_BS.
IPR004112. Fum_Rdtase/Succ_DHase_flav_C.
IPR001100. Pyr_nuc-diS_OxRdtase.
IPR011281. Succ_DHase_flav_su_fwd.
IPR014006. Succ_Dhase_frdA_Gneg.
[Graphical view]
PfamPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
PR00411. PNDRDTASEI.
TIGRFAMsTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHSA_RICTY
AccessionPrimary (citable) accession number: Q68XN9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2004
Last modified: November 25, 2008
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents