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Q68XN9

- SDHA_RICTY

UniProt

Q68XN9 - SDHA_RICTY

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Protein

Succinate dehydrogenase flavoprotein subunit

Gene
sdhA, RT0117
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

FAD.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei225 – 2251FAD By similarity
Binding sitei246 – 2461Substrate By similarity
Binding sitei258 – 2581Substrate By similarity
Active sitei290 – 2901Proton acceptor By similarity
Binding sitei357 – 3571Substrate By similarity
Binding sitei391 – 3911FAD By similarity
Binding sitei402 – 4021Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 236FAD By similarity
Nucleotide bindingi41 – 5616FAD By similarityAdd
BLAST
Nucleotide bindingi407 – 4082FAD By similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-125-MONOMER.
UniPathwayiUPA00223; UER01005.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase flavoprotein subunit (EC:1.3.5.1)
Gene namesi
Name:sdhA
Ordered Locus Names:RT0117
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 596596Succinate dehydrogenase flavoprotein subunitPRO_0000280978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491Tele-8alpha-FAD histidine By similarity

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

Protein-protein interaction databases

STRINGi257363.RT0117.

Structurei

3D structure databases

ProteinModelPortaliQ68XN9.
SMRiQ68XN9. Positions 5-596.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1053.
HOGENOMiHOG000160475.
KOiK00239.
OMAiCQGVVCW.
OrthoDBiEOG6M3PC4.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68XN9-1 [UniParc]FASTAAdd to Basket

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MTKAYNIIHH KFDVVVVGAG GAGLRSAFGM AKEGLNTACI TKIFPTRSHT    50
VAAQGGISAA LGNMGEDDWR WHMYDTVKGS DWLGDQDAIE YMCKNAPDAI 100
LELEHYGVPF SRTEDGKIYQ RPFGGMTTEY GKGKAAQRTC AAADRTGHAI 150
LHTLYQQSLK HKVQFFIEYF AIDLLMEDGE CRGVVAWNLD DGSLHCFRAH 200
NVVLATGGYG RAYFSATSAH TCTGDGGGMV IRAGLPLQDM EFVQFHPTGI 250
YSAGCLITEG ARGEGGYLVN ANGERFMERY APAAKDLASR DVVSRAMTIE 300
IREGRGVGEY KDHVFLHLNH LSPEILHRRL PGISETAKIF AGVDVTKDPI 350
PVLPTVHYNM GGIPTNYHGQ VIIKDGKNHN SIVNGIMAIG EAACVSVHGA 400
NRLGSNSLLD LVVFGRSSAL KAAELIKPVS PHKPLKKEIL EKIINRFDKI 450
RHANGNVLVA DLRLQMQRTM QSHVSVFRTQ ELLDEGARMI SEIRNRYKDI 500
KINDKSLIWN SDLVEALELD NLLDQALVTV YSAAARKESR GAHAREDYPD 550
RNDIDWIKHT LSSIDDSGQI ILDYKPVTLT TLTDEISTIP PVKRIY 596
Length:596
Mass (Da):65,743
Last modified:October 11, 2004 - v1
Checksum:i5B4F534F1490ECE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03603.1.
RefSeqiYP_067085.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03603; AAU03603; RT0117.
GeneIDi2959329.
KEGGirty:RT0117.
PATRICi17909406. VBIRicTyp34752_0124.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03603.1 .
RefSeqi YP_067085.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68XN9.
SMRi Q68XN9. Positions 5-596.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0117.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03603 ; AAU03603 ; RT0117 .
GeneIDi 2959329.
KEGGi rty:RT0117.
PATRICi 17909406. VBIRicTyp34752_0124.

Phylogenomic databases

eggNOGi COG1053.
HOGENOMi HOG000160475.
KOi K00239.
OMAi CQGVVCW.
OrthoDBi EOG6M3PC4.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01005 .
BioCyci RTYP257363:GJEQ-125-MONOMER.

Family and domain databases

Gene3Di 1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProi IPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view ]
Pfami PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiSDHA_RICTY
AccessioniPrimary (citable) accession number: Q68XN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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