Reviewed, UniProtKB/Swiss-Prot Q68XN7 (RS12_RICTY)

Names and origin

Protein names

Recommended name:
    30S ribosomal protein S12

Gene names

Name:	rpsL
Ordered Locus Names:	RT0119

Organism

Rickettsia typhi [Complete proteome] [HAMAP]

Taxonomic identifier

785 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	129 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	With S4 and S5 plays an important role in translational accuracy By similarity. Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit By similarity.
Subunit structure	Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex By similarity.
Sequence similarities	Belongs to the ribosomal protein S12P family.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding tRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Cellular component	small ribosomal subunit Inferred from electronic annotation. Source: InterPro
Molecular function	rRNA binding Inferred from electronic annotation. Source: HAMAP structural constituent of ribosome Inferred from electronic annotation. Source: InterPro tRNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 129	129	30S ribosomal protein S12 HAMAP MF_00403		PRO_0000146300
Amino acid modifications
	Modified residue	89	1	3-methylthioaspartic acid By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q68XN7-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 8E69645B54551B55	FASTA	129	14,279
	10 20 30 40 50 60 MPTYNQLVRF GRKSKIRKTK SPALESNPFK SGVCLVVKTV TPKKPNSALR KIATVRLSNK 70 80 90 100 110 120 RTVNAYIPGE KHSVKEHDRV LVRGGQVPDL PGVKYHIVLG AYDIAGVKGR KQGRSRYGAT RKQVAATKK

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017197 Genomic DNA. Translation: AAU03605.1.
RefSeq	YP_067087.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2958785.
GenomeReviews	Gene locus RT0119 in contig AE017197_GR.
KEGG	rty:RT0119.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG747181.
OMA	SPALKSC.
Enzyme and pathway databases
BioCyc	RTYP257363:RT0119-MON.
Family and domain databases
HAMAP	MF_00403. [Tree]
InterPro	IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR006032. Ribosomal_S12/S23. IPR005679. Ribosomal_S12_bac-type. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PANTHER	PTHR11652:SF1. Ribosom_S12_bac. 1 hit. PTHR11652. Ribosomal_S12_23. 1 hit.
Pfam	PF00164. Ribosomal_S12. 1 hit. [Graphical view]
PIRSF	PIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTS	PR01034. RIBOSOMALS12.
PROSITE	PS00055. RIBOSOMAL_S12. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RS12_RICTY

Accession

Primary (citable) accession number: Q68XN7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	October 11, 2004
Last modified:	December 15, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)