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Q68XI7

- ODO1_RICTY

UniProt

Q68XI7 - ODO1_RICTY

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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate.By similarity

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-180-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Ordered Locus Names:RT0171
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9339332-oxoglutarate dehydrogenase E1 componentPRO_0000288751Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi257363.RT0171.

Structurei

3D structure databases

ProteinModelPortaliQ68XI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiGFTTAPH.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68XI7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKYFNKTGY LFAGNAVFVE ELYRQYLANP NSVDQTWQEF FADIKDNNAL
60 70 80 90 100
LNKSTAKVIR PNPNVTKALL NNNLSYEGLH NLKAKEMISA YRRNAHYLAN
110 120 130 140 150
LDPLGLEIRK TKDELKLNIE AFGLDSSQLE ENINITDEFI GTWNCKLSEL
160 170 180 190 200
VTKLDKVYTS SIGVEFDQIE NVEEKNWLYT KLETEITFAS EEKRSILNDF
210 220 230 240 250
VEVECFEQFL HTKFPGAKRF SIEGGDSSIV AMNKAIDLSM NQGVEEIVIG
260 270 280 290 300
MAHRGRLNTL TKVVGKPYKA VIAGFINGNV FPDELNISGD VKYHLGYSAD
310 320 330 340 350
RVRANQKIHL SLADNPSHLE AINSIVAGKV RAKQDMLVDT KRSKVKAILL
360 370 380 390 400
HGDAAFCGQG VVAESLSMSP LTAYNVGGIL HFVINNQLGF TANAADTRAS
410 420 430 440 450
RYSTEFAKII AAPILHVNGD DIEAVLKATD IAVEYRQKFS KDVVVEIICY
460 470 480 490 500
RKYGHNEGDE PMYTQSKMYN IIKSKPTPGN IYANELVKSG IIDNNYYAKL
510 520 530 540 550
KEKFKIKLDK EYEQAKSYKQ ESHFLGGCWK GISRTRGKAA ITGVNKKILQ
560 570 580 590 600
DLGTKLCEIP KDFTINPKLV RLFEVRKNTL TTDQPIDWAT AEQLAFAHLL
610 620 630 640 650
CSGTNIRLTG QDSERGTFSH RHSILHNQID DTTYIPLNNL SKTQAQYEVA
660 670 680 690 700
NSNLAEYAVL GFEYGYSLAS PKNLVLWEAQ FGDFANGAQI IFDQFISSSA
710 720 730 740 750
TKWLRMSGLV VLLPHAFEGQ GPEHSSARLE RFLQLAAEEN MYITYPTTPA
760 770 780 790 800
SIFHLLRRQI LESIRKPLIV MSPKSLLRHK YAVSKLDELG ENTTFIPVLD
810 820 830 840 850
EVTKIDKNNI TKVILCSGKV YYDLFAKRVH NSNIVIIRLE QLYPFEKTLV
860 870 880 890 900
ASLLKKYNKA QAFIWCQEEP KNMGAWNYIA EHLNDALKEA EINNEFKYVG
910 920 930
REESASPAVG SLQVHNKQQE KLLMEALGDD IIK
Length:933
Mass (Da):105,257
Last modified:October 11, 2004 - v1
Checksum:iFD32A523811440FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03655.1.
RefSeqiYP_067137.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03655; AAU03655; RT0171.
GeneIDi2958630.
KEGGirty:RT0171.
PATRICi17909516. VBIRicTyp34752_0177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03655.1 .
RefSeqi YP_067137.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68XI7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0171.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03655 ; AAU03655 ; RT0171 .
GeneIDi 2958630.
KEGGi rty:RT0171.
PATRICi 17909516. VBIRicTyp34752_0177.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi GFTTAPH.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-180-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiODO1_RICTY
AccessioniPrimary (citable) accession number: Q68XI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3