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Q68XI7

- ODO1_RICTY

UniProt

Q68XI7 - ODO1_RICTY

Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-180-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
    Alternative name(s):
    Alpha-ketoglutarate dehydrogenase
    Gene namesi
    Name:sucA
    Ordered Locus Names:RT0171
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9339332-oxoglutarate dehydrogenase E1 componentPRO_0000288751Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi257363.RT0171.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68XI7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0567.
    HOGENOMiHOG000259588.
    KOiK00164.
    OMAiGFTTAPH.
    OrthoDBiEOG6V1M1F.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q68XI7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKYFNKTGY LFAGNAVFVE ELYRQYLANP NSVDQTWQEF FADIKDNNAL    50
    LNKSTAKVIR PNPNVTKALL NNNLSYEGLH NLKAKEMISA YRRNAHYLAN 100
    LDPLGLEIRK TKDELKLNIE AFGLDSSQLE ENINITDEFI GTWNCKLSEL 150
    VTKLDKVYTS SIGVEFDQIE NVEEKNWLYT KLETEITFAS EEKRSILNDF 200
    VEVECFEQFL HTKFPGAKRF SIEGGDSSIV AMNKAIDLSM NQGVEEIVIG 250
    MAHRGRLNTL TKVVGKPYKA VIAGFINGNV FPDELNISGD VKYHLGYSAD 300
    RVRANQKIHL SLADNPSHLE AINSIVAGKV RAKQDMLVDT KRSKVKAILL 350
    HGDAAFCGQG VVAESLSMSP LTAYNVGGIL HFVINNQLGF TANAADTRAS 400
    RYSTEFAKII AAPILHVNGD DIEAVLKATD IAVEYRQKFS KDVVVEIICY 450
    RKYGHNEGDE PMYTQSKMYN IIKSKPTPGN IYANELVKSG IIDNNYYAKL 500
    KEKFKIKLDK EYEQAKSYKQ ESHFLGGCWK GISRTRGKAA ITGVNKKILQ 550
    DLGTKLCEIP KDFTINPKLV RLFEVRKNTL TTDQPIDWAT AEQLAFAHLL 600
    CSGTNIRLTG QDSERGTFSH RHSILHNQID DTTYIPLNNL SKTQAQYEVA 650
    NSNLAEYAVL GFEYGYSLAS PKNLVLWEAQ FGDFANGAQI IFDQFISSSA 700
    TKWLRMSGLV VLLPHAFEGQ GPEHSSARLE RFLQLAAEEN MYITYPTTPA 750
    SIFHLLRRQI LESIRKPLIV MSPKSLLRHK YAVSKLDELG ENTTFIPVLD 800
    EVTKIDKNNI TKVILCSGKV YYDLFAKRVH NSNIVIIRLE QLYPFEKTLV 850
    ASLLKKYNKA QAFIWCQEEP KNMGAWNYIA EHLNDALKEA EINNEFKYVG 900
    REESASPAVG SLQVHNKQQE KLLMEALGDD IIK 933
    Length:933
    Mass (Da):105,257
    Last modified:October 11, 2004 - v1
    Checksum:iFD32A523811440FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03655.1.
    RefSeqiYP_067137.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03655; AAU03655; RT0171.
    GeneIDi2958630.
    KEGGirty:RT0171.
    PATRICi17909516. VBIRicTyp34752_0177.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03655.1 .
    RefSeqi YP_067137.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68XI7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0171.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03655 ; AAU03655 ; RT0171 .
    GeneIDi 2958630.
    KEGGi rty:RT0171.
    PATRICi 17909516. VBIRicTyp34752_0177.

    Phylogenomic databases

    eggNOGi COG0567.
    HOGENOMi HOG000259588.
    KOi K00164.
    OMAi GFTTAPH.
    OrthoDBi EOG6V1M1F.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-180-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiODO1_RICTY
    AccessioniPrimary (citable) accession number: Q68XI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3