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Q68XI7

- ODO1_RICTY

UniProt

Q68XI7 - ODO1_RICTY

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Protein
2-oxoglutarate dehydrogenase E1 component
Gene
sucA, RT0171
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-180-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Ordered Locus Names:RT0171
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9339332-oxoglutarate dehydrogenase E1 component
PRO_0000288751Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi257363.RT0171.

Structurei

3D structure databases

ProteinModelPortaliQ68XI7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiGFTTAPH.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68XI7-1 [UniParc]FASTAAdd to Basket

« Hide

MEKYFNKTGY LFAGNAVFVE ELYRQYLANP NSVDQTWQEF FADIKDNNAL    50
LNKSTAKVIR PNPNVTKALL NNNLSYEGLH NLKAKEMISA YRRNAHYLAN 100
LDPLGLEIRK TKDELKLNIE AFGLDSSQLE ENINITDEFI GTWNCKLSEL 150
VTKLDKVYTS SIGVEFDQIE NVEEKNWLYT KLETEITFAS EEKRSILNDF 200
VEVECFEQFL HTKFPGAKRF SIEGGDSSIV AMNKAIDLSM NQGVEEIVIG 250
MAHRGRLNTL TKVVGKPYKA VIAGFINGNV FPDELNISGD VKYHLGYSAD 300
RVRANQKIHL SLADNPSHLE AINSIVAGKV RAKQDMLVDT KRSKVKAILL 350
HGDAAFCGQG VVAESLSMSP LTAYNVGGIL HFVINNQLGF TANAADTRAS 400
RYSTEFAKII AAPILHVNGD DIEAVLKATD IAVEYRQKFS KDVVVEIICY 450
RKYGHNEGDE PMYTQSKMYN IIKSKPTPGN IYANELVKSG IIDNNYYAKL 500
KEKFKIKLDK EYEQAKSYKQ ESHFLGGCWK GISRTRGKAA ITGVNKKILQ 550
DLGTKLCEIP KDFTINPKLV RLFEVRKNTL TTDQPIDWAT AEQLAFAHLL 600
CSGTNIRLTG QDSERGTFSH RHSILHNQID DTTYIPLNNL SKTQAQYEVA 650
NSNLAEYAVL GFEYGYSLAS PKNLVLWEAQ FGDFANGAQI IFDQFISSSA 700
TKWLRMSGLV VLLPHAFEGQ GPEHSSARLE RFLQLAAEEN MYITYPTTPA 750
SIFHLLRRQI LESIRKPLIV MSPKSLLRHK YAVSKLDELG ENTTFIPVLD 800
EVTKIDKNNI TKVILCSGKV YYDLFAKRVH NSNIVIIRLE QLYPFEKTLV 850
ASLLKKYNKA QAFIWCQEEP KNMGAWNYIA EHLNDALKEA EINNEFKYVG 900
REESASPAVG SLQVHNKQQE KLLMEALGDD IIK 933
Length:933
Mass (Da):105,257
Last modified:October 11, 2004 - v1
Checksum:iFD32A523811440FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03655.1.
RefSeqiYP_067137.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03655; AAU03655; RT0171.
GeneIDi2958630.
KEGGirty:RT0171.
PATRICi17909516. VBIRicTyp34752_0177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03655.1 .
RefSeqi YP_067137.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68XI7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0171.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03655 ; AAU03655 ; RT0171 .
GeneIDi 2958630.
KEGGi rty:RT0171.
PATRICi 17909516. VBIRicTyp34752_0177.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi GFTTAPH.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-180-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiODO1_RICTY
AccessioniPrimary (citable) accession number: Q68XI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi