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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-180-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Ordered Locus Names:RT0171
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9339332-oxoglutarate dehydrogenase E1 componentPRO_0000288751Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi257363.RT0171.

Structurei

3D structure databases

ProteinModelPortaliQ68XI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68XI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKYFNKTGY LFAGNAVFVE ELYRQYLANP NSVDQTWQEF FADIKDNNAL
60 70 80 90 100
LNKSTAKVIR PNPNVTKALL NNNLSYEGLH NLKAKEMISA YRRNAHYLAN
110 120 130 140 150
LDPLGLEIRK TKDELKLNIE AFGLDSSQLE ENINITDEFI GTWNCKLSEL
160 170 180 190 200
VTKLDKVYTS SIGVEFDQIE NVEEKNWLYT KLETEITFAS EEKRSILNDF
210 220 230 240 250
VEVECFEQFL HTKFPGAKRF SIEGGDSSIV AMNKAIDLSM NQGVEEIVIG
260 270 280 290 300
MAHRGRLNTL TKVVGKPYKA VIAGFINGNV FPDELNISGD VKYHLGYSAD
310 320 330 340 350
RVRANQKIHL SLADNPSHLE AINSIVAGKV RAKQDMLVDT KRSKVKAILL
360 370 380 390 400
HGDAAFCGQG VVAESLSMSP LTAYNVGGIL HFVINNQLGF TANAADTRAS
410 420 430 440 450
RYSTEFAKII AAPILHVNGD DIEAVLKATD IAVEYRQKFS KDVVVEIICY
460 470 480 490 500
RKYGHNEGDE PMYTQSKMYN IIKSKPTPGN IYANELVKSG IIDNNYYAKL
510 520 530 540 550
KEKFKIKLDK EYEQAKSYKQ ESHFLGGCWK GISRTRGKAA ITGVNKKILQ
560 570 580 590 600
DLGTKLCEIP KDFTINPKLV RLFEVRKNTL TTDQPIDWAT AEQLAFAHLL
610 620 630 640 650
CSGTNIRLTG QDSERGTFSH RHSILHNQID DTTYIPLNNL SKTQAQYEVA
660 670 680 690 700
NSNLAEYAVL GFEYGYSLAS PKNLVLWEAQ FGDFANGAQI IFDQFISSSA
710 720 730 740 750
TKWLRMSGLV VLLPHAFEGQ GPEHSSARLE RFLQLAAEEN MYITYPTTPA
760 770 780 790 800
SIFHLLRRQI LESIRKPLIV MSPKSLLRHK YAVSKLDELG ENTTFIPVLD
810 820 830 840 850
EVTKIDKNNI TKVILCSGKV YYDLFAKRVH NSNIVIIRLE QLYPFEKTLV
860 870 880 890 900
ASLLKKYNKA QAFIWCQEEP KNMGAWNYIA EHLNDALKEA EINNEFKYVG
910 920 930
REESASPAVG SLQVHNKQQE KLLMEALGDD IIK
Length:933
Mass (Da):105,257
Last modified:October 11, 2004 - v1
Checksum:iFD32A523811440FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03655.1.
RefSeqiWP_011190642.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03655; AAU03655; RT0171.
KEGGirty:RT0171.
PATRICi17909516. VBIRicTyp34752_0177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03655.1.
RefSeqiWP_011190642.1. NC_006142.1.

3D structure databases

ProteinModelPortaliQ68XI7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0171.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU03655; AAU03655; RT0171.
KEGGirty:RT0171.
PATRICi17909516. VBIRicTyp34752_0177.

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-180-MONOMER.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiODO1_RICTY
AccessioniPrimary (citable) accession number: Q68XI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2004
Last modified: July 22, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.