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Q68XI7 (ODO1_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component

EC=1.2.4.2
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene names
Name:sucA
Ordered Locus Names:RT0171
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length933 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandThiamine pyrophosphate
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

tricarboxylic acid cycle

Inferred from electronic annotation. Source: InterPro

   Molecular_functionoxoglutarate dehydrogenase (succinyl-transferring) activity

Inferred from electronic annotation. Source: UniProtKB-EC

thiamine pyrophosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9339332-oxoglutarate dehydrogenase E1 component
PRO_0000288751

Sequences

Sequence LengthMass (Da)Tools
Q68XI7 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: FD32A523811440FB

FASTA933105,257
        10         20         30         40         50         60 
MEKYFNKTGY LFAGNAVFVE ELYRQYLANP NSVDQTWQEF FADIKDNNAL LNKSTAKVIR 

        70         80         90        100        110        120 
PNPNVTKALL NNNLSYEGLH NLKAKEMISA YRRNAHYLAN LDPLGLEIRK TKDELKLNIE 

       130        140        150        160        170        180 
AFGLDSSQLE ENINITDEFI GTWNCKLSEL VTKLDKVYTS SIGVEFDQIE NVEEKNWLYT 

       190        200        210        220        230        240 
KLETEITFAS EEKRSILNDF VEVECFEQFL HTKFPGAKRF SIEGGDSSIV AMNKAIDLSM 

       250        260        270        280        290        300 
NQGVEEIVIG MAHRGRLNTL TKVVGKPYKA VIAGFINGNV FPDELNISGD VKYHLGYSAD 

       310        320        330        340        350        360 
RVRANQKIHL SLADNPSHLE AINSIVAGKV RAKQDMLVDT KRSKVKAILL HGDAAFCGQG 

       370        380        390        400        410        420 
VVAESLSMSP LTAYNVGGIL HFVINNQLGF TANAADTRAS RYSTEFAKII AAPILHVNGD 

       430        440        450        460        470        480 
DIEAVLKATD IAVEYRQKFS KDVVVEIICY RKYGHNEGDE PMYTQSKMYN IIKSKPTPGN 

       490        500        510        520        530        540 
IYANELVKSG IIDNNYYAKL KEKFKIKLDK EYEQAKSYKQ ESHFLGGCWK GISRTRGKAA 

       550        560        570        580        590        600 
ITGVNKKILQ DLGTKLCEIP KDFTINPKLV RLFEVRKNTL TTDQPIDWAT AEQLAFAHLL 

       610        620        630        640        650        660 
CSGTNIRLTG QDSERGTFSH RHSILHNQID DTTYIPLNNL SKTQAQYEVA NSNLAEYAVL 

       670        680        690        700        710        720 
GFEYGYSLAS PKNLVLWEAQ FGDFANGAQI IFDQFISSSA TKWLRMSGLV VLLPHAFEGQ 

       730        740        750        760        770        780 
GPEHSSARLE RFLQLAAEEN MYITYPTTPA SIFHLLRRQI LESIRKPLIV MSPKSLLRHK 

       790        800        810        820        830        840 
YAVSKLDELG ENTTFIPVLD EVTKIDKNNI TKVILCSGKV YYDLFAKRVH NSNIVIIRLE 

       850        860        870        880        890        900 
QLYPFEKTLV ASLLKKYNKA QAFIWCQEEP KNMGAWNYIA EHLNDALKEA EINNEFKYVG 

       910        920        930 
REESASPAVG SLQVHNKQQE KLLMEALGDD IIK 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU03655.1.
RefSeqYP_067137.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68XI7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0171.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU03655; AAU03655; RT0171.
GeneID2958630.
KEGGrty:RT0171.
PATRIC17909516. VBIRicTyp34752_0177.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0567.
HOGENOMHOG000259588.
KOK00164.
OMAHILRRQL.
OrthoDBEOG6V1M1F.
ProtClustDBPRK09404.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-180-MONOMER.

Family and domain databases

InterProIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODO1_RICTY
AccessionPrimary (citable) accession number: Q68XI7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2004
Last modified: November 13, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names