Q68XI7 (ODO1_RICTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-oxoglutarate dehydrogenase E1 component
EC=1.2.4.2

Alternative name(s):
Alpha-ketoglutarate dehydrogenase

Gene names

Name:	sucA
Ordered Locus Names:	RT0171

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia typhi

Protein attributes

Sequence length	933 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.
Cofactor	Thiamine pyrophosphate By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: EC thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 933	933	2-oxoglutarate dehydrogenase E1 component		PRO_0000288751

Sequences

	Sequence		Length	Mass (Da)
	Q68XI7 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: FD32A523811440FB	FASTA	933	105,257
	10 20 30 40 50 60 MEKYFNKTGY LFAGNAVFVE ELYRQYLANP NSVDQTWQEF FADIKDNNAL LNKSTAKVIR 70 80 90 100 110 120 PNPNVTKALL NNNLSYEGLH NLKAKEMISA YRRNAHYLAN LDPLGLEIRK TKDELKLNIE 130 140 150 160 170 180 AFGLDSSQLE ENINITDEFI GTWNCKLSEL VTKLDKVYTS SIGVEFDQIE NVEEKNWLYT 190 200 210 220 230 240 KLETEITFAS EEKRSILNDF VEVECFEQFL HTKFPGAKRF SIEGGDSSIV AMNKAIDLSM 250 260 270 280 290 300 NQGVEEIVIG MAHRGRLNTL TKVVGKPYKA VIAGFINGNV FPDELNISGD VKYHLGYSAD 310 320 330 340 350 360 RVRANQKIHL SLADNPSHLE AINSIVAGKV RAKQDMLVDT KRSKVKAILL HGDAAFCGQG 370 380 390 400 410 420 VVAESLSMSP LTAYNVGGIL HFVINNQLGF TANAADTRAS RYSTEFAKII AAPILHVNGD 430 440 450 460 470 480 DIEAVLKATD IAVEYRQKFS KDVVVEIICY RKYGHNEGDE PMYTQSKMYN IIKSKPTPGN 490 500 510 520 530 540 IYANELVKSG IIDNNYYAKL KEKFKIKLDK EYEQAKSYKQ ESHFLGGCWK GISRTRGKAA 550 560 570 580 590 600 ITGVNKKILQ DLGTKLCEIP KDFTINPKLV RLFEVRKNTL TTDQPIDWAT AEQLAFAHLL 610 620 630 640 650 660 CSGTNIRLTG QDSERGTFSH RHSILHNQID DTTYIPLNNL SKTQAQYEVA NSNLAEYAVL 670 680 690 700 710 720 GFEYGYSLAS PKNLVLWEAQ FGDFANGAQI IFDQFISSSA TKWLRMSGLV VLLPHAFEGQ 730 740 750 760 770 780 GPEHSSARLE RFLQLAAEEN MYITYPTTPA SIFHLLRRQI LESIRKPLIV MSPKSLLRHK 790 800 810 820 830 840 YAVSKLDELG ENTTFIPVLD EVTKIDKNNI TKVILCSGKV YYDLFAKRVH NSNIVIIRLE 850 860 870 880 890 900 QLYPFEKTLV ASLLKKYNKA QAFIWCQEEP KNMGAWNYIA EHLNDALKEA EINNEFKYVG 910 920 930 REESASPAVG SLQVHNKQQE KLLMEALGDD IIK

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU03655.1.
RefSeq	YP_067137.1. NC_006142.1.
3D structure databases
ProteinModelPortal	Q68XI7.
ModBase	Search...
Protein-protein interaction databases
STRING	257363.RT0171.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAU03655; AAU03655; RT0171.
GeneID	2958630.
KEGG	rty:RT0171.
PATRIC	17909516. VBIRicTyp34752_0177.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0567.
HOGENOM	HOG000259588.
KO	K00164.
OMA	IIKRGGA.
ProtClustDB	PRK09404.
Enzyme and pathway databases
BioCyc	RTYP257363:GJEQ-180-MONOMER.
Family and domain databases
InterPro	IPR011603. 2oxoglutarate_DH_E1. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
PANTHER	PTHR23152. PTHR23152. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODO1_RICTY

Accession

Primary (citable) accession number: Q68XI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program