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Q68XH5

- DAPD_RICTY

UniProt

Q68XH5 - DAPD_RICTY

Protein

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Gene

dapD

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei106 – 1061SubstrateUniRule annotation
    Binding sitei143 – 1431SubstrateUniRule annotation

    GO - Molecular functioni

    1. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
    2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-193-MONOMER.
    UniPathwayiUPA00034; UER00019.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseUniRule annotation (EC:2.3.1.117UniRule annotation)
    Alternative name(s):
    Tetrahydrodipicolinate N-succinyltransferaseUniRule annotation
    Short name:
    THDP succinyltransferaseUniRule annotation
    Short name:
    THP succinyltransferaseUniRule annotation
    Short name:
    Tetrahydropicolinate succinylaseUniRule annotation
    Gene namesi
    Name:dapDUniRule annotation
    Ordered Locus Names:RT0183
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2742742,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferasePRO_0000196965Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi257363.RT0183.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68XH5.
    SMRiQ68XH5. Positions 1-274.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transferase hexapeptide repeat family.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG2171.
    HOGENOMiHOG000003295.
    KOiK00674.
    OMAiSCAQVGA.
    OrthoDBiEOG68H8BV.

    Family and domain databases

    Gene3Di1.10.166.10. 1 hit.
    HAMAPiMF_00811. DapD.
    InterProiIPR005664. DapD_Trfase_Hexpep_rpt_fam.
    IPR001451. Hexapep_transf.
    IPR023180. THP_succinylTrfase_dom1.
    IPR011004. Trimer_LpxA-like.
    [Graphical view]
    PANTHERiPTHR19136:SF52. PTHR19136:SF52. 1 hit.
    PfamiPF00132. Hexapep. 1 hit.
    PF14805. THDPS_N_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF51161. SSF51161. 1 hit.
    TIGRFAMsiTIGR00965. dapD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q68XH5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDIIKEIEE AWQIKENILN DSLKLIKLKS ILNESIKSLN QGIIRVCEKQ    50
    GNQWKVNEWV KKAILLYFIT TESQLYNNNY NSWYDKVAPK FPADTDKNIF 100
    KEAAIRKVPG AIVRTGTYIA KNVVIMPSFI NIGAYIDEGT MIDTWATIGS 150
    CAQIGKNCHI SGGSGIGGVL EPLQAKPVII EDNCFVGARS EIAEGIIVEE 200
    GSVISMGVFI GSSTKIVYRD TGKIIYGRIP AYSVVVPGVL PSPEAGKPGL 250
    YCVVIVKQVD KTTRAKVSIN DLLR 274
    Length:274
    Mass (Da):30,112
    Last modified:October 11, 2004 - v1
    Checksum:iB824B16A01F06DFC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03667.1.
    RefSeqiYP_067149.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03667; AAU03667; RT0183.
    GeneIDi2959140.
    KEGGirty:RT0183.
    PATRICi17909546. VBIRicTyp34752_0192.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03667.1 .
    RefSeqi YP_067149.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68XH5.
    SMRi Q68XH5. Positions 1-274.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0183.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03667 ; AAU03667 ; RT0183 .
    GeneIDi 2959140.
    KEGGi rty:RT0183.
    PATRICi 17909546. VBIRicTyp34752_0192.

    Phylogenomic databases

    eggNOGi COG2171.
    HOGENOMi HOG000003295.
    KOi K00674.
    OMAi SCAQVGA.
    OrthoDBi EOG68H8BV.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00019 .
    BioCyci RTYP257363:GJEQ-193-MONOMER.

    Family and domain databases

    Gene3Di 1.10.166.10. 1 hit.
    HAMAPi MF_00811. DapD.
    InterProi IPR005664. DapD_Trfase_Hexpep_rpt_fam.
    IPR001451. Hexapep_transf.
    IPR023180. THP_succinylTrfase_dom1.
    IPR011004. Trimer_LpxA-like.
    [Graphical view ]
    PANTHERi PTHR19136:SF52. PTHR19136:SF52. 1 hit.
    Pfami PF00132. Hexapep. 1 hit.
    PF14805. THDPS_N_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51161. SSF51161. 1 hit.
    TIGRFAMsi TIGR00965. dapD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiDAPD_RICTY
    AccessioniPrimary (citable) accession number: Q68XH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3