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Q68XH5

- DAPD_RICTY

UniProt

Q68XH5 - DAPD_RICTY

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Protein
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
Gene
dapD, RT0183
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061Substrate By similarity
Binding sitei143 – 1431Substrate By similarity

GO - Molecular functioni

  1. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
  2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-193-MONOMER.
UniPathwayiUPA00034; UER00019.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC:2.3.1.117)
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferase
Short name:
THDP succinyltransferase
Short name:
THP succinyltransferase
Short name:
Tetrahydropicolinate succinylase
Gene namesi
Name:dapD
Ordered Locus Names:RT0183
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2742742,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseUniRule annotation
PRO_0000196965Add
BLAST

Interactioni

Subunit structurei

Homotrimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0183.

Structurei

3D structure databases

ProteinModelPortaliQ68XH5.
SMRiQ68XH5. Positions 1-274.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG2171.
HOGENOMiHOG000003295.
KOiK00674.
OMAiSCAQVGA.
OrthoDBiEOG68H8BV.

Family and domain databases

Gene3Di1.10.166.10. 1 hit.
HAMAPiMF_00811. DapD.
InterProiIPR005664. DapD_Trfase_Hexpep_rpt_fam.
IPR001451. Hexapep_transf.
IPR023180. THP_succinylTrfase_dom1.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PANTHERiPTHR19136:SF52. PTHR19136:SF52. 1 hit.
PfamiPF00132. Hexapep. 1 hit.
PF14805. THDPS_N_2. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR00965. dapD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68XH5-1 [UniParc]FASTAAdd to Basket

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MSDIIKEIEE AWQIKENILN DSLKLIKLKS ILNESIKSLN QGIIRVCEKQ    50
GNQWKVNEWV KKAILLYFIT TESQLYNNNY NSWYDKVAPK FPADTDKNIF 100
KEAAIRKVPG AIVRTGTYIA KNVVIMPSFI NIGAYIDEGT MIDTWATIGS 150
CAQIGKNCHI SGGSGIGGVL EPLQAKPVII EDNCFVGARS EIAEGIIVEE 200
GSVISMGVFI GSSTKIVYRD TGKIIYGRIP AYSVVVPGVL PSPEAGKPGL 250
YCVVIVKQVD KTTRAKVSIN DLLR 274
Length:274
Mass (Da):30,112
Last modified:October 11, 2004 - v1
Checksum:iB824B16A01F06DFC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03667.1.
RefSeqiYP_067149.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03667; AAU03667; RT0183.
GeneIDi2959140.
KEGGirty:RT0183.
PATRICi17909546. VBIRicTyp34752_0192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03667.1 .
RefSeqi YP_067149.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68XH5.
SMRi Q68XH5. Positions 1-274.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0183.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03667 ; AAU03667 ; RT0183 .
GeneIDi 2959140.
KEGGi rty:RT0183.
PATRICi 17909546. VBIRicTyp34752_0192.

Phylogenomic databases

eggNOGi COG2171.
HOGENOMi HOG000003295.
KOi K00674.
OMAi SCAQVGA.
OrthoDBi EOG68H8BV.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00019 .
BioCyci RTYP257363:GJEQ-193-MONOMER.

Family and domain databases

Gene3Di 1.10.166.10. 1 hit.
HAMAPi MF_00811. DapD.
InterProi IPR005664. DapD_Trfase_Hexpep_rpt_fam.
IPR001451. Hexapep_transf.
IPR023180. THP_succinylTrfase_dom1.
IPR011004. Trimer_LpxA-like.
[Graphical view ]
PANTHERi PTHR19136:SF52. PTHR19136:SF52. 1 hit.
Pfami PF00132. Hexapep. 1 hit.
PF14805. THDPS_N_2. 1 hit.
[Graphical view ]
SUPFAMi SSF51161. SSF51161. 1 hit.
TIGRFAMsi TIGR00965. dapD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiDAPD_RICTY
AccessioniPrimary (citable) accession number: Q68XH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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