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Q68XG6

- RNH2_RICTY

UniProt

Q68XG6 - RNH2_RICTY

Protein

Ribonuclease HII

Gene

rnhB

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

    Cofactori

    Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi21 – 211Divalent metal cationUniRule annotation
    Metal bindingi22 – 221Divalent metal cationUniRule annotation
    Metal bindingi112 – 1121Divalent metal cationUniRule annotation

    GO - Molecular functioni

    1. manganese ion binding Source: UniProtKB-HAMAP
    2. RNA binding Source: InterPro
    3. RNA-DNA hybrid ribonuclease activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. RNA catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-202-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease HIIUniRule annotation (EC:3.1.26.4UniRule annotation)
    Short name:
    RNase HIIUniRule annotation
    Gene namesi
    Name:rnhBUniRule annotation
    Ordered Locus Names:RT0192
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 193193Ribonuclease HIIPRO_0000111614Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi257363.RT0192.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68XG6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RNase HII family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0164.
    HOGENOMiHOG000100288.
    KOiK03470.
    OMAiIMVDLAQ.
    OrthoDBiEOG6BKJC8.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    HAMAPiMF_00052_B. RNase_HII_B.
    InterProiIPR022898. RNase_HII.
    IPR001352. RNase_HII/HIII.
    IPR024567. RNase_HII/HIII_dom.
    IPR012337. RNaseH-like_dom.
    [Graphical view]
    PANTHERiPTHR10954. PTHR10954. 1 hit.
    PfamiPF01351. RNase_HII. 1 hit.
    [Graphical view]
    SUPFAMiSSF53098. SSF53098. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q68XG6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVNLLQYEQ KYHNYIVAGV DEAGRGSLVG PVVASAVIID KVDIISGIKD    50
    SKKLSKNKRD ILYEQITSNY VWSTAIIEHT EIDDINILEA TKKACTIAVA 100
    NLSLKPEKIL VDGNMKFSDV RFISIINGDN LSLSIAAASI IAKVTRDRLM 150
    LELSAEYPQY LWHKNYGYGT REHIEAINTH GLSSYHRKSF KFC 193
    Length:193
    Mass (Da):21,680
    Last modified:October 11, 2004 - v1
    Checksum:i9C0902A70186E618
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03676.1.
    RefSeqiYP_067158.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03676; AAU03676; RT0192.
    GeneIDi2958802.
    KEGGirty:RT0192.
    PATRICi17909568. VBIRicTyp34752_0203.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03676.1 .
    RefSeqi YP_067158.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68XG6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0192.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03676 ; AAU03676 ; RT0192 .
    GeneIDi 2958802.
    KEGGi rty:RT0192.
    PATRICi 17909568. VBIRicTyp34752_0203.

    Phylogenomic databases

    eggNOGi COG0164.
    HOGENOMi HOG000100288.
    KOi K03470.
    OMAi IMVDLAQ.
    OrthoDBi EOG6BKJC8.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-202-MONOMER.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    HAMAPi MF_00052_B. RNase_HII_B.
    InterProi IPR022898. RNase_HII.
    IPR001352. RNase_HII/HIII.
    IPR024567. RNase_HII/HIII_dom.
    IPR012337. RNaseH-like_dom.
    [Graphical view ]
    PANTHERi PTHR10954. PTHR10954. 1 hit.
    Pfami PF01351. RNase_HII. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53098. SSF53098. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiRNH2_RICTY
    AccessioniPrimary (citable) accession number: Q68XG6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3