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Q68XG6

- RNH2_RICTY

UniProt

Q68XG6 - RNH2_RICTY

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Protein

Ribonuclease HII

Gene
rnhB, RT0192
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi21 – 211Divalent metal cation By similarity
Metal bindingi22 – 221Divalent metal cation By similarity
Metal bindingi112 – 1121Divalent metal cation By similarity

GO - Molecular functioni

  1. manganese ion binding Source: UniProtKB-HAMAP
  2. RNA binding Source: InterPro
  3. RNA-DNA hybrid ribonuclease activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-202-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HII (EC:3.1.26.4)
Short name:
RNase HII
Gene namesi
Name:rnhB
Ordered Locus Names:RT0192
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Ribonuclease HIIUniRule annotationPRO_0000111614Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0192.

Structurei

3D structure databases

ProteinModelPortaliQ68XG6.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase HII family.

Phylogenomic databases

eggNOGiCOG0164.
HOGENOMiHOG000100288.
KOiK03470.
OMAiIMVDLAQ.
OrthoDBiEOG6BKJC8.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00052_B. RNase_HII_B.
InterProiIPR022898. RNase_HII.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10954. PTHR10954. 1 hit.
PfamiPF01351. RNase_HII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68XG6-1 [UniParc]FASTAAdd to Basket

« Hide

MEVNLLQYEQ KYHNYIVAGV DEAGRGSLVG PVVASAVIID KVDIISGIKD    50
SKKLSKNKRD ILYEQITSNY VWSTAIIEHT EIDDINILEA TKKACTIAVA 100
NLSLKPEKIL VDGNMKFSDV RFISIINGDN LSLSIAAASI IAKVTRDRLM 150
LELSAEYPQY LWHKNYGYGT REHIEAINTH GLSSYHRKSF KFC 193
Length:193
Mass (Da):21,680
Last modified:October 11, 2004 - v1
Checksum:i9C0902A70186E618
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03676.1.
RefSeqiYP_067158.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03676; AAU03676; RT0192.
GeneIDi2958802.
KEGGirty:RT0192.
PATRICi17909568. VBIRicTyp34752_0203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03676.1 .
RefSeqi YP_067158.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68XG6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0192.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03676 ; AAU03676 ; RT0192 .
GeneIDi 2958802.
KEGGi rty:RT0192.
PATRICi 17909568. VBIRicTyp34752_0203.

Phylogenomic databases

eggNOGi COG0164.
HOGENOMi HOG000100288.
KOi K03470.
OMAi IMVDLAQ.
OrthoDBi EOG6BKJC8.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-202-MONOMER.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
HAMAPi MF_00052_B. RNase_HII_B.
InterProi IPR022898. RNase_HII.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
[Graphical view ]
PANTHERi PTHR10954. PTHR10954. 1 hit.
Pfami PF01351. RNase_HII. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiRNH2_RICTY
AccessioniPrimary (citable) accession number: Q68XG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi