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Q68XG4 (GLRX1_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutaredoxin-1
Gene names
Name:grxC1
Synonyms:grx
Ordered Locus Names:RT0194
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length104 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the glutaredoxin family.

Contains 1 glutaredoxin domain.

Ontologies

Keywords
   Biological processElectron transport
Transport
   Cellular componentCytoplasm
   DomainRedox-active center
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionelectron carrier activity

Inferred from electronic annotation. Source: InterPro

protein disulfide oxidoreductase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 104104Glutaredoxin-1
PRO_0000288737

Regions

Domain1 – 9696Glutaredoxin

Amino acid modifications

Disulfide bond17 ↔ 20Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68XG4 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 493A295658C5E9BB

FASTA10411,662
        10         20         30         40         50         60 
MNKSILHTII IYTLASCPYC IKAKALLDKK NVIYEEIEVS NFTQEEKEAF IKKSGGKNTV 

        70         80         90        100 
PQIFIDNMHV GGCDDLFNLE QDGRLDKLLE TQPKNKNSLT VSGA 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU03678.1.
RefSeqYP_067160.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68XG4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0194.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU03678; AAU03678; RT0194.
GeneID2958812.
KEGGrty:RT0194.
PATRIC17909572. VBIRicTyp34752_0205.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0695.
HOGENOMHOG000095203.
KOK03676.
OMAIYTRQFC.
OrthoDBEOG6Z3KS6.
ProtClustDBCLSK870795.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-204-MONOMER.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR011767. GLR_AS.
IPR002109. Glutaredoxin.
IPR014025. Glutaredoxin_subgr.
IPR011900. GRX_bact.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00462. Glutaredoxin. 1 hit.
[Graphical view]
PRINTSPR00160. GLUTAREDOXIN.
SUPFAMSSF52833. SSF52833. 1 hit.
TIGRFAMsTIGR02181. GRX_bact. 1 hit.
PROSITEPS00195. GLUTAREDOXIN_1. 1 hit.
PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLRX1_RICTY
AccessionPrimary (citable) accession number: Q68XG4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2004
Last modified: November 13, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names