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Q68XG4

- GLRX1_RICTY

UniProt

Q68XG4 - GLRX1_RICTY

Protein

Glutaredoxin-1

Gene

grxC1

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins By similarity.By similarity

    GO - Molecular functioni

    1. electron carrier activity Source: InterPro
    2. protein disulfide oxidoreductase activity Source: InterPro

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro

    Keywords - Biological processi

    Electron transport, Transport

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-204-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutaredoxin-1
    Gene namesi
    Name:grxC1
    Synonyms:grx
    Ordered Locus Names:RT0194
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 104104Glutaredoxin-1PRO_0000288737Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi17 ↔ 20Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi257363.RT0194.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68XG4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 9696GlutaredoxinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glutaredoxin family.Curated
    Contains 1 glutaredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG0695.
    HOGENOMiHOG000095203.
    KOiK03676.
    OMAiVEYTEYC.
    OrthoDBiEOG6Z3KS6.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR011767. GLR_AS.
    IPR002109. Glutaredoxin.
    IPR014025. Glutaredoxin_subgr.
    IPR011900. GRX_bact.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00462. Glutaredoxin. 1 hit.
    [Graphical view]
    PRINTSiPR00160. GLUTAREDOXIN.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR02181. GRX_bact. 1 hit.
    PROSITEiPS00195. GLUTAREDOXIN_1. 1 hit.
    PS51354. GLUTAREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68XG4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKSILHTII IYTLASCPYC IKAKALLDKK NVIYEEIEVS NFTQEEKEAF    50
    IKKSGGKNTV PQIFIDNMHV GGCDDLFNLE QDGRLDKLLE TQPKNKNSLT 100
    VSGA 104
    Length:104
    Mass (Da):11,662
    Last modified:October 11, 2004 - v1
    Checksum:i493A295658C5E9BB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03678.1.
    RefSeqiYP_067160.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03678; AAU03678; RT0194.
    GeneIDi2958812.
    KEGGirty:RT0194.
    PATRICi17909572. VBIRicTyp34752_0205.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03678.1 .
    RefSeqi YP_067160.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68XG4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0194.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03678 ; AAU03678 ; RT0194 .
    GeneIDi 2958812.
    KEGGi rty:RT0194.
    PATRICi 17909572. VBIRicTyp34752_0205.

    Phylogenomic databases

    eggNOGi COG0695.
    HOGENOMi HOG000095203.
    KOi K03676.
    OMAi VEYTEYC.
    OrthoDBi EOG6Z3KS6.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-204-MONOMER.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR011767. GLR_AS.
    IPR002109. Glutaredoxin.
    IPR014025. Glutaredoxin_subgr.
    IPR011900. GRX_bact.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00462. Glutaredoxin. 1 hit.
    [Graphical view ]
    PRINTSi PR00160. GLUTAREDOXIN.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR02181. GRX_bact. 1 hit.
    PROSITEi PS00195. GLUTAREDOXIN_1. 1 hit.
    PS51354. GLUTAREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiGLRX1_RICTY
    AccessioniPrimary (citable) accession number: Q68XG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3