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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. isomerase activity Source: UniProtKB-HAMAP
  2. transferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. queuosine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-215-MONOMER.
UniPathwayiUPA00392.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:RT0204
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375S-adenosylmethionine:tRNA ribosyltransferase-isomerasePRO_0000231368Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0204.

Structurei

3D structure databases

ProteinModelPortaliQ68XF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0809.
HOGENOMiHOG000004402.
KOiK07568.
OMAiLPKYIKR.
OrthoDBiEOG6X6RBB.

Family and domain databases

HAMAPiMF_00113. QueA.
InterProiIPR003699. QueA.
[Graphical view]
PfamiPF02547. Queuosine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF111337. SSF111337. 2 hits.

Sequencei

Sequence statusi: Complete.

Q68XF6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLSDFDFNV PNALIAQYPS SERDNSDLLI AGTKHIKTKF YNIIDYLKEG
60 70 80 90 100
DLLVFNNSKV IKAKLHLGKN ITINLNKKLS DNCWGAFAKP ARKLNIGDEF
110 120 130 140 150
YFDTHKIIIT EKLAMGEIKV KFILNNISMI KFLDKYGEMP LPFYIKRTSS
160 170 180 190 200
VCCSNMALFC DHDNTLKITS ISHNSNTVNF RSTDSMIDST NDNDRYQTIY
210 220 230 240 250
SQIEGSVAAP TAGLHFTKDI LDKLKTKGIN TAFVTLHVGA GTFLPVKTEN
260 270 280 290 300
IHKHKMHTEY CSITAETAEI INKTKQKGRD IIAVGTTTLR TLESSCNNGI
310 320 330 340 350
VKAGNFETDI FITPGFNFQI VDMLLTNFHF PKSTLFILIC AFAGFKEMHA
360 370
LYKYAIKEKM RFFSYGDATL LYRKV
Length:375
Mass (Da):42,439
Last modified:October 11, 2004 - v1
Checksum:i94FB6DD70545EB29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03686.1.
RefSeqiYP_067168.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03686; AAU03686; RT0204.
GeneIDi2959397.
KEGGirty:RT0204.
PATRICi17909590. VBIRicTyp34752_0212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03686.1.
RefSeqiYP_067168.1. NC_006142.1.

3D structure databases

ProteinModelPortaliQ68XF6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0204.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU03686; AAU03686; RT0204.
GeneIDi2959397.
KEGGirty:RT0204.
PATRICi17909590. VBIRicTyp34752_0212.

Phylogenomic databases

eggNOGiCOG0809.
HOGENOMiHOG000004402.
KOiK07568.
OMAiLPKYIKR.
OrthoDBiEOG6X6RBB.

Enzyme and pathway databases

UniPathwayiUPA00392.
BioCyciRTYP257363:GJEQ-215-MONOMER.

Family and domain databases

HAMAPiMF_00113. QueA.
InterProiIPR003699. QueA.
[Graphical view]
PfamiPF02547. Queuosine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF111337. SSF111337. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiQUEA_RICTY
AccessioniPrimary (citable) accession number: Q68XF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2004
Last modified: January 7, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.