Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q68XF6 (QUEA_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomerase

EC=2.4.99.17
Alternative name(s):
Queuosine biosynthesis protein QueA
Gene names
Name:queA
Ordered Locus Names:RT0204
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) By similarity. HAMAP-Rule MF_00113

Catalytic activity

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine34 in tRNA = L-methionine + adenine + epoxyqueuosine34 in tRNA. HAMAP-Rule MF_00113

Pathway

tRNA modification; tRNA-queuosine biosynthesis. HAMAP-Rule MF_00113

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00113

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00113.

Sequence similarities

Belongs to the QueA family.

Ontologies

Keywords
   Biological processQueuosine biosynthesis
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processqueuosine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

transferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375S-adenosylmethionine:tRNA ribosyltransferase-isomerase HAMAP-Rule MF_00113
PRO_0000231368

Sequences

Sequence LengthMass (Da)Tools
Q68XF6 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 94FB6DD70545EB29

FASTA37542,439
        10         20         30         40         50         60 
MKLSDFDFNV PNALIAQYPS SERDNSDLLI AGTKHIKTKF YNIIDYLKEG DLLVFNNSKV 

        70         80         90        100        110        120 
IKAKLHLGKN ITINLNKKLS DNCWGAFAKP ARKLNIGDEF YFDTHKIIIT EKLAMGEIKV 

       130        140        150        160        170        180 
KFILNNISMI KFLDKYGEMP LPFYIKRTSS VCCSNMALFC DHDNTLKITS ISHNSNTVNF 

       190        200        210        220        230        240 
RSTDSMIDST NDNDRYQTIY SQIEGSVAAP TAGLHFTKDI LDKLKTKGIN TAFVTLHVGA 

       250        260        270        280        290        300 
GTFLPVKTEN IHKHKMHTEY CSITAETAEI INKTKQKGRD IIAVGTTTLR TLESSCNNGI 

       310        320        330        340        350        360 
VKAGNFETDI FITPGFNFQI VDMLLTNFHF PKSTLFILIC AFAGFKEMHA LYKYAIKEKM 

       370 
RFFSYGDATL LYRKV 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU03686.1.
RefSeqYP_067168.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68XF6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0204.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU03686; AAU03686; RT0204.
GeneID2959397.
KEGGrty:RT0204.
PATRIC17909590. VBIRicTyp34752_0212.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0809.
HOGENOMHOG000004402.
KOK07568.
OMADVTTHKM.
OrthoDBEOG6X6RBB.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-215-MONOMER.
UniPathwayUPA00392.

Family and domain databases

HAMAPMF_00113. QueA.
InterProIPR003699. QueA.
[Graphical view]
PfamPF02547. Queuosine_synth. 1 hit.
[Graphical view]
SUPFAMSSF111337. SSF111337. 2 hits.
ProtoNetSearch...

Entry information

Entry nameQUEA_RICTY
AccessionPrimary (citable) accession number: Q68XF6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways