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Q68XF6

- QUEA_RICTY

UniProt

Q68XF6 - QUEA_RICTY

Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. isomerase activity Source: UniProtKB-HAMAP
    2. transferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. queuosine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Queuosine biosynthesis

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-215-MONOMER.
    UniPathwayiUPA00392.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
    Alternative name(s):
    Queuosine biosynthesis protein QueAUniRule annotation
    Gene namesi
    Name:queAUniRule annotation
    Ordered Locus Names:RT0204
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375S-adenosylmethionine:tRNA ribosyltransferase-isomerasePRO_0000231368Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi257363.RT0204.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68XF6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the QueA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0809.
    HOGENOMiHOG000004402.
    KOiK07568.
    OMAiDVTTHKM.
    OrthoDBiEOG6X6RBB.

    Family and domain databases

    HAMAPiMF_00113. QueA.
    InterProiIPR003699. QueA.
    [Graphical view]
    PfamiPF02547. Queuosine_synth. 1 hit.
    [Graphical view]
    SUPFAMiSSF111337. SSF111337. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q68XF6-1 [UniParc]FASTAAdd to Basket

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    MKLSDFDFNV PNALIAQYPS SERDNSDLLI AGTKHIKTKF YNIIDYLKEG    50
    DLLVFNNSKV IKAKLHLGKN ITINLNKKLS DNCWGAFAKP ARKLNIGDEF 100
    YFDTHKIIIT EKLAMGEIKV KFILNNISMI KFLDKYGEMP LPFYIKRTSS 150
    VCCSNMALFC DHDNTLKITS ISHNSNTVNF RSTDSMIDST NDNDRYQTIY 200
    SQIEGSVAAP TAGLHFTKDI LDKLKTKGIN TAFVTLHVGA GTFLPVKTEN 250
    IHKHKMHTEY CSITAETAEI INKTKQKGRD IIAVGTTTLR TLESSCNNGI 300
    VKAGNFETDI FITPGFNFQI VDMLLTNFHF PKSTLFILIC AFAGFKEMHA 350
    LYKYAIKEKM RFFSYGDATL LYRKV 375
    Length:375
    Mass (Da):42,439
    Last modified:October 11, 2004 - v1
    Checksum:i94FB6DD70545EB29
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03686.1.
    RefSeqiYP_067168.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03686; AAU03686; RT0204.
    GeneIDi2959397.
    KEGGirty:RT0204.
    PATRICi17909590. VBIRicTyp34752_0212.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03686.1 .
    RefSeqi YP_067168.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68XF6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0204.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03686 ; AAU03686 ; RT0204 .
    GeneIDi 2959397.
    KEGGi rty:RT0204.
    PATRICi 17909590. VBIRicTyp34752_0212.

    Phylogenomic databases

    eggNOGi COG0809.
    HOGENOMi HOG000004402.
    KOi K07568.
    OMAi DVTTHKM.
    OrthoDBi EOG6X6RBB.

    Enzyme and pathway databases

    UniPathwayi UPA00392 .
    BioCyci RTYP257363:GJEQ-215-MONOMER.

    Family and domain databases

    HAMAPi MF_00113. QueA.
    InterProi IPR003699. QueA.
    [Graphical view ]
    Pfami PF02547. Queuosine_synth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111337. SSF111337. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiQUEA_RICTY
    AccessioniPrimary (citable) accession number: Q68XF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3