Q68XB5 (LPXC_RICTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
EC=3.5.1.-

Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylase

Gene names

Name:	lpxC
Ordered Locus Names:	RT0246

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia typhi

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00388
Catalytic activity	UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate. HAMAP-Rule MF_00388
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. HAMAP-Rule MF_00388
Sequence similarities	Belongs to the LpxC family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase HAMAP-Rule MF_00388		PRO_0000191952

Sequences

	Sequence		Length	Mass (Da)
	Q68XB5 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 0E083D1CE37A8137	FASTA	289	32,097
	10 20 30 40 50 60 MQQSTLLKPV SCYGIGVHTG KRTQLTIEPA KENTGIIFIR TDISSENNYI EASYYNVSDT 70 80 90 100 110 120 LLSTTISNNH KIQVSTIEHL MAALWGCSID NAVIKIDGPE VPIMDGSSKP FVFMIECAGK 130 140 150 160 170 180 KLQNAPKKYL KILKEIKVVN KDCELYCTPS EHITVDLTID FSSKAIGKQN LNFGVQESFT 190 200 210 220 230 240 KNIADARTFG FIKDVEYLKS KGLAQGASFE NAIGIDEHDK VLNPSGLRYA DEFVRHKLLD 250 260 270 280 LFGDLYTSGI SIVSAIKGYK TSHAFNNELL HKIFSDTTSY KFVTSNELS

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU03727.1.
RefSeq	YP_067209.1. NC_006142.1.
3D structure databases
ProteinModelPortal	Q68XB5.
ModBase	Search...
Protein-protein interaction databases
STRING	257363.RT0246.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAU03727; AAU03727; RT0246.
GeneID	2959354.
KEGG	rty:RT0246.
PATRIC	17909676. VBIRicTyp34752_0254.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0774.
HOGENOM	HOG000256664.
KO	K02535.
OMA	KAYKSGH.
ProtClustDB	PRK13186.
Enzyme and pathway databases
BioCyc	RTYP257363:GJEQ-258-MONOMER.
UniPathway	UPA00359; UER00478.
Family and domain databases
Gene3D	3.30.1700.10. 1 hit. 3.30.230.20. 1 hit.
HAMAP	MF_00388. LpxC.
InterPro	IPR020568. Ribosomal_S5_D2-typ_fold. IPR004463. UDP-acyl_GlcNac_deAcase. IPR011334. UDP-acyl_GlcNac_deAcase_C. IPR015870. UDP-acyl_N-AcGlcN_deAcase_N. [Graphical view]
Pfam	PF03331. LpxC. 1 hit. [Graphical view]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
TIGRFAMs	TIGR00325. lpxC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXC_RICTY

Accession

Primary (citable) accession number: Q68XB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program