Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q68XB5

- LPXC_RICTY

UniProt

Q68XB5 - LPXC_RICTY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Gene

lpxC

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Source: InterPro

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-258-MONOMER.
UniPathwayiUPA00359; UER00478.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylaseUniRule annotation (EC:3.5.1.-UniRule annotation)
Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylaseUniRule annotation
Gene namesi
Name:lpxCUniRule annotation
Ordered Locus Names:RT0246
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylasePRO_0000191952Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0246.

Structurei

3D structure databases

ProteinModelPortaliQ68XB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxC family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0774.
HOGENOMiHOG000256664.
KOiK02535.
OMAiDEFIRHK.
OrthoDBiEOG6PGK74.

Family and domain databases

Gene3Di3.30.1700.10. 1 hit.
3.30.230.20. 1 hit.
HAMAPiMF_00388. LpxC.
InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
IPR004463. UDP-acyl_GlcNac_deAcase.
IPR011334. UDP-acyl_GlcNac_deAcase_C.
IPR015870. UDP-acyl_N-AcGlcN_deAcase_N.
[Graphical view]
PfamiPF03331. LpxC. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 2 hits.
TIGRFAMsiTIGR00325. lpxC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68XB5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQQSTLLKPV SCYGIGVHTG KRTQLTIEPA KENTGIIFIR TDISSENNYI
60 70 80 90 100
EASYYNVSDT LLSTTISNNH KIQVSTIEHL MAALWGCSID NAVIKIDGPE
110 120 130 140 150
VPIMDGSSKP FVFMIECAGK KLQNAPKKYL KILKEIKVVN KDCELYCTPS
160 170 180 190 200
EHITVDLTID FSSKAIGKQN LNFGVQESFT KNIADARTFG FIKDVEYLKS
210 220 230 240 250
KGLAQGASFE NAIGIDEHDK VLNPSGLRYA DEFVRHKLLD LFGDLYTSGI
260 270 280
SIVSAIKGYK TSHAFNNELL HKIFSDTTSY KFVTSNELS
Length:289
Mass (Da):32,097
Last modified:October 11, 2004 - v1
Checksum:i0E083D1CE37A8137
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03727.1.
RefSeqiYP_067209.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03727; AAU03727; RT0246.
GeneIDi2959354.
KEGGirty:RT0246.
PATRICi17909676. VBIRicTyp34752_0254.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03727.1 .
RefSeqi YP_067209.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68XB5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0246.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03727 ; AAU03727 ; RT0246 .
GeneIDi 2959354.
KEGGi rty:RT0246.
PATRICi 17909676. VBIRicTyp34752_0254.

Phylogenomic databases

eggNOGi COG0774.
HOGENOMi HOG000256664.
KOi K02535.
OMAi DEFIRHK.
OrthoDBi EOG6PGK74.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00478 .
BioCyci RTYP257363:GJEQ-258-MONOMER.

Family and domain databases

Gene3Di 3.30.1700.10. 1 hit.
3.30.230.20. 1 hit.
HAMAPi MF_00388. LpxC.
InterProi IPR020568. Ribosomal_S5_D2-typ_fold.
IPR004463. UDP-acyl_GlcNac_deAcase.
IPR011334. UDP-acyl_GlcNac_deAcase_C.
IPR015870. UDP-acyl_N-AcGlcN_deAcase_N.
[Graphical view ]
Pfami PF03331. LpxC. 1 hit.
[Graphical view ]
SUPFAMi SSF54211. SSF54211. 2 hits.
TIGRFAMsi TIGR00325. lpxC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiLPXC_RICTY
AccessioniPrimary (citable) accession number: Q68XB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3