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Q68XB5 (LPXC_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

EC=3.5.1.-
Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylase
Gene names
Name:lpxC
Ordered Locus Names:RT0246
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00388

Catalytic activity

UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate. HAMAP-Rule MF_00388

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. HAMAP-Rule MF_00388

Sequence similarities

Belongs to the LpxC family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase HAMAP-Rule MF_00388
PRO_0000191952

Sequences

Sequence LengthMass (Da)Tools
Q68XB5 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 0E083D1CE37A8137

FASTA28932,097
        10         20         30         40         50         60 
MQQSTLLKPV SCYGIGVHTG KRTQLTIEPA KENTGIIFIR TDISSENNYI EASYYNVSDT 

        70         80         90        100        110        120 
LLSTTISNNH KIQVSTIEHL MAALWGCSID NAVIKIDGPE VPIMDGSSKP FVFMIECAGK 

       130        140        150        160        170        180 
KLQNAPKKYL KILKEIKVVN KDCELYCTPS EHITVDLTID FSSKAIGKQN LNFGVQESFT 

       190        200        210        220        230        240 
KNIADARTFG FIKDVEYLKS KGLAQGASFE NAIGIDEHDK VLNPSGLRYA DEFVRHKLLD 

       250        260        270        280 
LFGDLYTSGI SIVSAIKGYK TSHAFNNELL HKIFSDTTSY KFVTSNELS 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU03727.1.
RefSeqYP_067209.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68XB5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0246.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU03727; AAU03727; RT0246.
GeneID2959354.
KEGGrty:RT0246.
PATRIC17909676. VBIRicTyp34752_0254.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0774.
HOGENOMHOG000256664.
KOK02535.
OMADEFIRHK.
OrthoDBEOG6PGK74.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-258-MONOMER.
UniPathwayUPA00359; UER00478.

Family and domain databases

Gene3D3.30.1700.10. 1 hit.
3.30.230.20. 1 hit.
HAMAPMF_00388. LpxC.
InterProIPR020568. Ribosomal_S5_D2-typ_fold.
IPR004463. UDP-acyl_GlcNac_deAcase.
IPR011334. UDP-acyl_GlcNac_deAcase_C.
IPR015870. UDP-acyl_N-AcGlcN_deAcase_N.
[Graphical view]
PfamPF03331. LpxC. 1 hit.
[Graphical view]
SUPFAMSSF54211. SSF54211. 2 hits.
TIGRFAMsTIGR00325. lpxC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXC_RICTY
AccessionPrimary (citable) accession number: Q68XB5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways