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Q68XB2

- RLUC_RICTY

UniProt

Q68XB2 - RLUC_RICTY

Protein

Ribosomal large subunit pseudouridine synthase C

Gene

rluC

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA.By similarity

    Catalytic activityi

    23S rRNA uridine(955)/uridine(2504)/uridine(2580) = 23S rRNA pseudouridine(955)/pseudouridine(2504)/pseudouridine(2580).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei140 – 1401By similarity

    GO - Molecular functioni

    1. pseudouridine synthase activity Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. pseudouridine synthesis Source: InterPro
    2. rRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-262-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal large subunit pseudouridine synthase C (EC:5.4.99.24)
    Alternative name(s):
    23S rRNA pseudouridine(955/2504/2580) synthase
    rRNA pseudouridylate synthase C
    rRNA-uridine isomerase C
    Gene namesi
    Name:rluC
    Ordered Locus Names:RT0249
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303Ribosomal large subunit pseudouridine synthase CPRO_0000286666Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi257363.RT0249.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68XB2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 7060S4 RNA-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the pseudouridine synthase RluA family.Curated
    Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0564.
    HOGENOMiHOG000275914.
    KOiK06179.
    OMAiLNYKGAD.
    OrthoDBiEOG6P070X.

    Family and domain databases

    Gene3Di3.10.290.10. 1 hit.
    InterProiIPR020103. PsdUridine_synth_cat_dom.
    IPR006224. PsdUridine_synth_RluC/D_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view]
    PfamiPF00849. PseudoU_synth_2. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view]
    SMARTiSM00363. S4. 1 hit.
    [Graphical view]
    SUPFAMiSSF55120. SSF55120. 1 hit.
    PROSITEiPS01129. PSI_RLU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68XB2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIIDVNTPIP FRLDKYLKRL YPSLTQGVIE KALRQKQVTV NFQKAEANLR    50
    VKEGDTIFIN DYFNLPVTQH ETLVFADAEI KLAKKILTDY LIYEDDHLIA 100
    INKPASLATQ GGSKINLSID SALKYLNYQG ADFKLVHRLD KETSGLLLIA 150
    KNYLSSVKLH DAFKEKLVIK KYFAITYGRP VKNVGIVKSN IGKSKGRMFK 200
    ITDIDSDNGK LAITYYKLLK SLNNNLFLIE FMPVTGRMHQ LRLHAQLLGC 250
    PILGDDKYGN KEVMPYSKYM FLHANNIYLS ESIVGKEIKL EAKLPFYFTR 300
    RLT 303
    Length:303
    Mass (Da):34,662
    Last modified:October 11, 2004 - v1
    Checksum:i1E80BF92A819B1A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03730.1.
    RefSeqiYP_067212.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03730; AAU03730; RT0249.
    GeneIDi2958538.
    KEGGirty:RT0249.
    PATRICi17909684. VBIRicTyp34752_0258.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03730.1 .
    RefSeqi YP_067212.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68XB2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0249.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03730 ; AAU03730 ; RT0249 .
    GeneIDi 2958538.
    KEGGi rty:RT0249.
    PATRICi 17909684. VBIRicTyp34752_0258.

    Phylogenomic databases

    eggNOGi COG0564.
    HOGENOMi HOG000275914.
    KOi K06179.
    OMAi LNYKGAD.
    OrthoDBi EOG6P070X.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-262-MONOMER.

    Family and domain databases

    Gene3Di 3.10.290.10. 1 hit.
    InterProi IPR020103. PsdUridine_synth_cat_dom.
    IPR006224. PsdUridine_synth_RluC/D_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view ]
    Pfami PF00849. PseudoU_synth_2. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view ]
    SMARTi SM00363. S4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55120. SSF55120. 1 hit.
    PROSITEi PS01129. PSI_RLU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiRLUC_RICTY
    AccessioniPrimary (citable) accession number: Q68XB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3