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Q68XB2

- RLUC_RICTY

UniProt

Q68XB2 - RLUC_RICTY

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Protein

Ribosomal large subunit pseudouridine synthase C

Gene

rluC

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA.By similarity

Catalytic activityi

23S rRNA uridine(955)/uridine(2504)/uridine(2580) = 23S rRNA pseudouridine(955)/pseudouridine(2504)/pseudouridine(2580).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei140 – 1401By similarity

GO - Molecular functioni

  1. pseudouridine synthase activity Source: InterPro
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. pseudouridine synthesis Source: InterPro
  2. rRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-262-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal large subunit pseudouridine synthase C (EC:5.4.99.24)
Alternative name(s):
23S rRNA pseudouridine(955/2504/2580) synthase
rRNA pseudouridylate synthase C
rRNA-uridine isomerase C
Gene namesi
Name:rluC
Ordered Locus Names:RT0249
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Ribosomal large subunit pseudouridine synthase CPRO_0000286666Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0249.

Structurei

3D structure databases

ProteinModelPortaliQ68XB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 7060S4 RNA-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pseudouridine synthase RluA family.Curated
Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0564.
HOGENOMiHOG000275914.
KOiK06179.
OMAiLNYKGAD.
OrthoDBiEOG6P070X.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68XB2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIIDVNTPIP FRLDKYLKRL YPSLTQGVIE KALRQKQVTV NFQKAEANLR
60 70 80 90 100
VKEGDTIFIN DYFNLPVTQH ETLVFADAEI KLAKKILTDY LIYEDDHLIA
110 120 130 140 150
INKPASLATQ GGSKINLSID SALKYLNYQG ADFKLVHRLD KETSGLLLIA
160 170 180 190 200
KNYLSSVKLH DAFKEKLVIK KYFAITYGRP VKNVGIVKSN IGKSKGRMFK
210 220 230 240 250
ITDIDSDNGK LAITYYKLLK SLNNNLFLIE FMPVTGRMHQ LRLHAQLLGC
260 270 280 290 300
PILGDDKYGN KEVMPYSKYM FLHANNIYLS ESIVGKEIKL EAKLPFYFTR

RLT
Length:303
Mass (Da):34,662
Last modified:October 11, 2004 - v1
Checksum:i1E80BF92A819B1A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03730.1.
RefSeqiYP_067212.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03730; AAU03730; RT0249.
GeneIDi2958538.
KEGGirty:RT0249.
PATRICi17909684. VBIRicTyp34752_0258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03730.1 .
RefSeqi YP_067212.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68XB2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0249.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03730 ; AAU03730 ; RT0249 .
GeneIDi 2958538.
KEGGi rty:RT0249.
PATRICi 17909684. VBIRicTyp34752_0258.

Phylogenomic databases

eggNOGi COG0564.
HOGENOMi HOG000275914.
KOi K06179.
OMAi LNYKGAD.
OrthoDBi EOG6P070X.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-262-MONOMER.

Family and domain databases

Gene3Di 3.10.290.10. 1 hit.
InterProi IPR020103. PsdUridine_synth_cat_dom.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view ]
Pfami PF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view ]
SMARTi SM00363. S4. 1 hit.
[Graphical view ]
SUPFAMi SSF55120. SSF55120. 1 hit.
PROSITEi PS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiRLUC_RICTY
AccessioniPrimary (citable) accession number: Q68XB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3