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Q68XB2 (RLUC_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribosomal large subunit pseudouridine synthase C

EC=5.4.99.24
Alternative name(s):
23S rRNA pseudouridine(955/2504/2580) synthase
rRNA pseudouridylate synthase C
rRNA-uridine isomerase C
Gene names
Name:rluC
Ordered Locus Names:RT0249
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA By similarity.

Catalytic activity

23S rRNA uridine(955)/uridine(2504)/uridine(2580) = 23S rRNA pseudouridine(955)/pseudouridine(2504)/pseudouridine(2580).

Sequence similarities

Belongs to the pseudouridine synthase RluA family.

Contains 1 S4 RNA-binding domain.

Ontologies

Keywords
   Biological processrRNA processing
   LigandRNA-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpseudouridine synthesis

Inferred from electronic annotation. Source: InterPro

rRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

pseudouridine synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303Ribosomal large subunit pseudouridine synthase C
PRO_0000286666

Regions

Domain11 – 7060S4 RNA-binding

Sites

Active site1401 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68XB2 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 1E80BF92A819B1A1

FASTA30334,662
        10         20         30         40         50         60 
MIIDVNTPIP FRLDKYLKRL YPSLTQGVIE KALRQKQVTV NFQKAEANLR VKEGDTIFIN 

        70         80         90        100        110        120 
DYFNLPVTQH ETLVFADAEI KLAKKILTDY LIYEDDHLIA INKPASLATQ GGSKINLSID 

       130        140        150        160        170        180 
SALKYLNYQG ADFKLVHRLD KETSGLLLIA KNYLSSVKLH DAFKEKLVIK KYFAITYGRP 

       190        200        210        220        230        240 
VKNVGIVKSN IGKSKGRMFK ITDIDSDNGK LAITYYKLLK SLNNNLFLIE FMPVTGRMHQ 

       250        260        270        280        290        300 
LRLHAQLLGC PILGDDKYGN KEVMPYSKYM FLHANNIYLS ESIVGKEIKL EAKLPFYFTR 


RLT 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU03730.1.
RefSeqYP_067212.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68XB2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0249.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU03730; AAU03730; RT0249.
GeneID2958538.
KEGGrty:RT0249.
PATRIC17909684. VBIRicTyp34752_0258.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0564.
HOGENOMHOG000275914.
KOK06179.
OMAFTEVFTH.
OrthoDBEOG6P070X.
ProtClustDBCLSK2517043.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-262-MONOMER.

Family and domain databases

Gene3D3.10.290.10. 1 hit.
InterProIPR020103. PsdUridine_synth_cat_dom.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTSM00363. S4. 1 hit.
[Graphical view]
SUPFAMSSF55120. SSF55120. 1 hit.
PROSITEPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRLUC_RICTY
AccessionPrimary (citable) accession number: Q68XB2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2004
Last modified: November 13, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names