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Q68XA8

- ODPB_RICTY

UniProt

Q68XA8 - ODPB_RICTY

Protein

Pyruvate dehydrogenase E1 component subunit beta

Gene

pdhB

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei59 – 591Thiamine pyrophosphateBy similarity

    GO - Molecular functioni

    1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

    GO - Biological processi

    1. acetyl-CoA biosynthetic process from pyruvate Source: InterPro
    2. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Pyruvate, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-266-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate dehydrogenase E1 component subunit beta (EC:1.2.4.1)
    Gene namesi
    Name:pdhB
    Ordered Locus Names:RT0253
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Pyruvate dehydrogenase E1 component subunit betaPRO_0000288762Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta chain.

    Protein-protein interaction databases

    STRINGi257363.RT0253.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68XA8.
    SMRiQ68XA8. Positions 1-322.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0022.
    HOGENOMiHOG000281450.
    KOiK00162.
    OMAiYASWYAH.
    OrthoDBiEOG6JQH4C.

    Family and domain databases

    Gene3Di3.40.50.920. 1 hit.
    3.40.50.970. 1 hit.
    InterProiIPR027110. PDHB.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR005476. Transketolase_C.
    [Graphical view]
    PANTHERiPTHR11624:SF56. PTHR11624:SF56. 1 hit.
    PfamiPF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view]
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 1 hit.
    SSF52922. SSF52922. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q68XA8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQITVREALR DAMQEEMLRD DKVFVIGEEV AEYQGAYKVT QGLLEQFGSK    50
    RVIDTPITEY GFAGLAVGAA FAGLRPIVEF MTFNFAMQAF DHIVNSAAKT 100
    HYMSGGQVKC PIVFRGPNGA ASRVAAQHSQ NYTACYSHIP GLKVVAPYSA 150
    EDHKGLMLTA IRDDNPVIFL ENEILYGHSF DVPDIIEPIP FSKAKILKEG 200
    SNVTIVTFSI QVKLALDVVN ILQNDNIDCE LIDLRTIKPL DTNMIIESVK 250
    KTNRLVIVEE GWFFAGVGAS IASIVMKEAF DYLDAPIEIV SGKDVPLPYA 300
    VNLEKLAMPS ANDLIEAVKK VCYYTI 326
    Length:326
    Mass (Da):35,961
    Last modified:October 11, 2004 - v1
    Checksum:iA6BBCABCA1C930EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03734.1.
    RefSeqiYP_067216.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03734; AAU03734; RT0253.
    GeneIDi2959223.
    KEGGirty:RT0253.
    PATRICi17909692. VBIRicTyp34752_0262.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03734.1 .
    RefSeqi YP_067216.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68XA8.
    SMRi Q68XA8. Positions 1-322.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0253.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03734 ; AAU03734 ; RT0253 .
    GeneIDi 2959223.
    KEGGi rty:RT0253.
    PATRICi 17909692. VBIRicTyp34752_0262.

    Phylogenomic databases

    eggNOGi COG0022.
    HOGENOMi HOG000281450.
    KOi K00162.
    OMAi YASWYAH.
    OrthoDBi EOG6JQH4C.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-266-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.920. 1 hit.
    3.40.50.970. 1 hit.
    InterProi IPR027110. PDHB.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR005476. Transketolase_C.
    [Graphical view ]
    PANTHERi PTHR11624:SF56. PTHR11624:SF56. 1 hit.
    Pfami PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 1 hit.
    SSF52922. SSF52922. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiODPB_RICTY
    AccessioniPrimary (citable) accession number: Q68XA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names

    External Data

    Dasty 3