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Q68XA8

- ODPB_RICTY

UniProt

Q68XA8 - ODPB_RICTY

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Protein
Pyruvate dehydrogenase E1 component subunit beta
Gene
pdhB, RT0253
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei59 – 591Thiamine pyrophosphate By similarity

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. acetyl-CoA biosynthetic process from pyruvate Source: InterPro
  2. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-266-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit beta (EC:1.2.4.1)
Gene namesi
Name:pdhB
Ordered Locus Names:RT0253
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Pyruvate dehydrogenase E1 component subunit beta
PRO_0000288762Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

STRINGi257363.RT0253.

Structurei

3D structure databases

ProteinModelPortaliQ68XA8.
SMRiQ68XA8. Positions 1-322.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0022.
HOGENOMiHOG000281450.
KOiK00162.
OMAiYASWYAH.
OrthoDBiEOG6JQH4C.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProiIPR027110. PDHB.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
[Graphical view]
PANTHERiPTHR11624:SF56. PTHR11624:SF56. 1 hit.
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68XA8-1 [UniParc]FASTAAdd to Basket

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MQITVREALR DAMQEEMLRD DKVFVIGEEV AEYQGAYKVT QGLLEQFGSK    50
RVIDTPITEY GFAGLAVGAA FAGLRPIVEF MTFNFAMQAF DHIVNSAAKT 100
HYMSGGQVKC PIVFRGPNGA ASRVAAQHSQ NYTACYSHIP GLKVVAPYSA 150
EDHKGLMLTA IRDDNPVIFL ENEILYGHSF DVPDIIEPIP FSKAKILKEG 200
SNVTIVTFSI QVKLALDVVN ILQNDNIDCE LIDLRTIKPL DTNMIIESVK 250
KTNRLVIVEE GWFFAGVGAS IASIVMKEAF DYLDAPIEIV SGKDVPLPYA 300
VNLEKLAMPS ANDLIEAVKK VCYYTI 326
Length:326
Mass (Da):35,961
Last modified:October 11, 2004 - v1
Checksum:iA6BBCABCA1C930EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03734.1.
RefSeqiYP_067216.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03734; AAU03734; RT0253.
GeneIDi2959223.
KEGGirty:RT0253.
PATRICi17909692. VBIRicTyp34752_0262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03734.1 .
RefSeqi YP_067216.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68XA8.
SMRi Q68XA8. Positions 1-322.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0253.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03734 ; AAU03734 ; RT0253 .
GeneIDi 2959223.
KEGGi rty:RT0253.
PATRICi 17909692. VBIRicTyp34752_0262.

Phylogenomic databases

eggNOGi COG0022.
HOGENOMi HOG000281450.
KOi K00162.
OMAi YASWYAH.
OrthoDBi EOG6JQH4C.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-266-MONOMER.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProi IPR027110. PDHB.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
[Graphical view ]
PANTHERi PTHR11624:SF56. PTHR11624:SF56. 1 hit.
Pfami PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view ]
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiODPB_RICTY
AccessioniPrimary (citable) accession number: Q68XA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names

External Data

Dasty 3

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