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Q68XA5

- IDH_RICTY

UniProt

Q68XA5 - IDH_RICTY

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei89 – 891SubstrateBy similarity
    Binding sitei99 – 991SubstrateBy similarity
    Binding sitei121 – 1211SubstrateBy similarity
    Sitei128 – 1281Critical for catalysisBy similarity
    Sitei175 – 1751Critical for catalysisBy similarity
    Metal bindingi208 – 2081Magnesium or manganeseBy similarity
    Binding sitei208 – 2081SubstrateBy similarity
    Metal bindingi232 – 2321Magnesium or manganeseBy similarity
    Metal bindingi236 – 2361Magnesium or manganeseBy similarity

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, NADP

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-269-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
    Short name:
    IDH
    Alternative name(s):
    IDP
    NADP(+)-specific ICDH
    Oxalosuccinate decarboxylase
    Gene namesi
    Name:icd
    Ordered Locus Names:RT0256
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483Isocitrate dehydrogenase [NADP]PRO_0000083558Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei83 – 831PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi257363.RT0256.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68XA5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0473.
    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiDLCEYSE.
    OrthoDBiEOG65XN31.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR014273. Isocitrate_DH_aproteobac-typ.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02924. ICDH_alpha. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68XA5-1 [UniParc]FASTAAdd to Basket

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    MAEFTPITIA YGDGIGPEIM DAVLYILRQA EARISLETIE VGEKLYKKHY    50
    TSGISEESWN VIQRTGIILK APITTPQSGG YKSLNVTIRK TLQLFANIRP 100
    AVSFHPFTRT LHPNLNLTII RENEEDLYSG IEYRQTHNMY ESLKLISHTG 150
    CKKIIRYAFE YAVKNNRKKV TCLSKDNIMK FSDGIFHRVF NEIAKEYPQI 200
    DNEHYIIDIG TAKLATTPEI FDIIVTSNLY GDIISDVAAE ISGSVGLAGS 250
    ANIGQHYAMF EAVHGSAPDI AGKGIANPSG LLNAAIMMLV HIGQGDIASL 300
    IENAWKKTIE DGVHTFDIYS EHSSSKKVCT KEFAEEVIKR LGQLPMTLPK 350
    ASYPLIVKKQ ESKIEYKIDT TEVKKLVGTD IFINIHVFSA HDIADKINKL 400
    DIGNFELKTI SSKGLKLWPH DLRFEIISDH WCCRFMNKDG TEIKHLDIII 450
    LLQALSKANI DFIKVENLFE FDGVACYSLA QGE 483
    Length:483
    Mass (Da):54,161
    Last modified:October 11, 2004 - v1
    Checksum:iD6AAA410411169AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03737.1.
    RefSeqiYP_067219.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03737; AAU03737; RT0256.
    GeneIDi2958917.
    KEGGirty:RT0256.
    PATRICi17909698. VBIRicTyp34752_0265.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03737.1 .
    RefSeqi YP_067219.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68XA5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0256.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03737 ; AAU03737 ; RT0256 .
    GeneIDi 2958917.
    KEGGi rty:RT0256.
    PATRICi 17909698. VBIRicTyp34752_0265.

    Phylogenomic databases

    eggNOGi COG0473.
    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi DLCEYSE.
    OrthoDBi EOG65XN31.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-269-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR014273. Isocitrate_DH_aproteobac-typ.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02924. ICDH_alpha. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiIDH_RICTY
    AccessioniPrimary (citable) accession number: Q68XA5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3