Reviewed, UniProtKB/Swiss-Prot Q68XA0 (UCRI_RICTY)

Names and origin

Protein names

Recommended name:
    Ubiquinol-cytochrome c reductase iron-sulfur subunit
    EC=1.10.2.2
Alternative name(s):
    Rieske iron-sulfur protein
      Short name=RISP

Gene names

Name:	petA
Ordered Locus Names:	RT0261

Organism

Rickettsia typhi [Complete proteome] [HAMAP]

Taxonomic identifier

785 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
Catalytic activity	QH(2) + 2 ferricytochrome c = Q + 2 ferrocytochrome c + 2 H(+).
Cofactor	Binds 1 2Fe-2S cluster per subunit By similarity.
Subunit structure	The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.
Subcellular location	Cell membrane; Single-pass membrane proteinPotential.
Miscellaneous	The Rieske protein is a high potential 2Fe-2S protein.
Sequence similarities	Contains 1 Rieske domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	2Fe-2S Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquinol-cytochrome-c reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 177	177	Ubiquinol-cytochrome c reductase iron-sulfur subunit		PRO_0000286644
Regions
	Transmembrane	18 – 38	21	Potential
	Domain	88 – 175	88	Rieske
Sites
	Metal binding	120	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	122	1	Iron-sulfur (2Fe-2S); via pros nitrogen By similarity
	Metal binding	139	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	142	1	Iron-sulfur (2Fe-2S); via pros nitrogen By similarity
Amino acid modifications
	Disulfide bond	125 ↔ 141		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q68XA0-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 3ADC9B2B6E69DB59	FASTA	177	19,191
	10 20 30 40 50 60 MSDTEDNRNK QTTRRDFIVL TASSVAAVGA ACAFWPIIDS LNPSTDVLAL SSIEVDLSSI 70 80 90 100 110 120 AIGQTVTVKW QGKPIFITNR TPDGIASARA VKMSELIDPE KDEVRVKAGH DNWLVTIGIC 130 140 150 160 170 THLGCVPLSN QGEYNGWFCP CHGSQYDSSG RVRKGPASLN LVVPPYIFIS DTKIRIG

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017197 Genomic DNA. Translation: AAU03742.1.
RefSeq	YP_067224.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2959250.
GenomeReviews	Gene locus RT0261 in contig AE017197_GR.
KEGG	rty:RT0261.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q68XA0.
Enzyme and pathway databases
BioCyc	RTYP257363:RT0261-MON.
Family and domain databases
InterPro	IPR014349. Rieske. IPR005805. Rieske_C. IPR006317. Rieske_proteo. IPR005806. Rieske_reg. IPR006311. Tat. [Graphical view]
Gene3D	G3DSA:2.102.10.10. Rieske_reg. 1 hit.
PANTHER	PTHR10134. Rieske. 1 hit.
Pfam	PF00355. Rieske. 1 hit. [Graphical view]
PRINTS	PR00162. RIESKE.
TIGRFAMs	TIGR01416. Rieske_proteo. 1 hit. TIGR01409. TAT_signal_seq. 1 hit.
PROSITE	PS51296. RIESKE. 1 hit. PS51318. TAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UCRI_RICTY

Accession

Primary (citable) accession number: Q68XA0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	October 11, 2004
Last modified:	November 25, 2008
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)