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Q68XA0

- UCRI_RICTY

UniProt

Q68XA0 - UCRI_RICTY

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Protein

Ubiquinol-cytochrome c reductase iron-sulfur subunit

Gene
petA, RT0261
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.

Catalytic activityi

Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+.

Cofactori

Binds 1 2Fe-2S cluster per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi120 – 1201Iron-sulfur (2Fe-2S) By similarity
Metal bindingi122 – 1221Iron-sulfur (2Fe-2S); via pros nitrogen By similarity
Metal bindingi139 – 1391Iron-sulfur (2Fe-2S) By similarity
Metal bindingi142 – 1421Iron-sulfur (2Fe-2S); via pros nitrogen By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. ubiquinol-cytochrome-c reductase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-274-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinol-cytochrome c reductase iron-sulfur subunit (EC:1.10.2.2)
Alternative name(s):
Rieske iron-sulfur protein
Short name:
RISP
Gene namesi
Name:petA
Ordered Locus Names:RT0261
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Ubiquinol-cytochrome c reductase iron-sulfur subunitPRO_0000286644Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi125 ↔ 141 By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

Protein-protein interaction databases

STRINGi257363.RT0261.

Structurei

3D structure databases

ProteinModelPortaliQ68XA0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 17588RieskeAdd
BLAST

Sequence similaritiesi

Contains 1 Rieske domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0723.
HOGENOMiHOG000255193.
KOiK00411.
OMAiWIINRTD.
OrthoDBiEOG6RNQD9.

Family and domain databases

Gene3Di2.102.10.10. 1 hit.
InterProiIPR017941. Rieske_2Fe-2S.
IPR014349. Rieske_Fe-S_prot.
IPR005805. Rieske_Fe-S_prot_C.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
IPR019470. Ubiq_cytC_Rdtase_Fe-S_su_TAT.
IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su.
[Graphical view]
PANTHERiPTHR10134. PTHR10134. 1 hit.
PfamiPF00355. Rieske. 1 hit.
PF10399. UCR_Fe-S_N. 1 hit.
[Graphical view]
PRINTSiPR00162. RIESKE.
SUPFAMiSSF50022. SSF50022. 1 hit.
TIGRFAMsiTIGR01416. Rieske_proteo. 1 hit.
TIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS51296. RIESKE. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68XA0-1 [UniParc]FASTAAdd to Basket

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MSDTEDNRNK QTTRRDFIVL TASSVAAVGA ACAFWPIIDS LNPSTDVLAL    50
SSIEVDLSSI AIGQTVTVKW QGKPIFITNR TPDGIASARA VKMSELIDPE 100
KDEVRVKAGH DNWLVTIGIC THLGCVPLSN QGEYNGWFCP CHGSQYDSSG 150
RVRKGPASLN LVVPPYIFIS DTKIRIG 177
Length:177
Mass (Da):19,191
Last modified:October 11, 2004 - v1
Checksum:i3ADC9B2B6E69DB59
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03742.1.
RefSeqiYP_067224.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03742; AAU03742; RT0261.
GeneIDi2959250.
KEGGirty:RT0261.
PATRICi17909708. VBIRicTyp34752_0270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03742.1 .
RefSeqi YP_067224.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68XA0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0261.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03742 ; AAU03742 ; RT0261 .
GeneIDi 2959250.
KEGGi rty:RT0261.
PATRICi 17909708. VBIRicTyp34752_0270.

Phylogenomic databases

eggNOGi COG0723.
HOGENOMi HOG000255193.
KOi K00411.
OMAi WIINRTD.
OrthoDBi EOG6RNQD9.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-274-MONOMER.

Family and domain databases

Gene3Di 2.102.10.10. 1 hit.
InterProi IPR017941. Rieske_2Fe-2S.
IPR014349. Rieske_Fe-S_prot.
IPR005805. Rieske_Fe-S_prot_C.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
IPR019470. Ubiq_cytC_Rdtase_Fe-S_su_TAT.
IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su.
[Graphical view ]
PANTHERi PTHR10134. PTHR10134. 1 hit.
Pfami PF00355. Rieske. 1 hit.
PF10399. UCR_Fe-S_N. 1 hit.
[Graphical view ]
PRINTSi PR00162. RIESKE.
SUPFAMi SSF50022. SSF50022. 1 hit.
TIGRFAMsi TIGR01416. Rieske_proteo. 1 hit.
TIGR01409. TAT_signal_seq. 1 hit.
PROSITEi PS51296. RIESKE. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiUCRI_RICTY
AccessioniPrimary (citable) accession number: Q68XA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The Rieske protein is a high potential 2Fe-2S protein.

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi