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Q68XA0

- UCRI_RICTY

UniProt

Q68XA0 - UCRI_RICTY

Protein

Ubiquinol-cytochrome c reductase iron-sulfur subunit

Gene

petA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.

    Catalytic activityi

    Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+.

    Cofactori

    Binds 1 2Fe-2S cluster per subunit.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi120 – 1201Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
    Metal bindingi122 – 1221Iron-sulfur (2Fe-2S); via pros nitrogenPROSITE-ProRule annotation
    Metal bindingi139 – 1391Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
    Metal bindingi142 – 1421Iron-sulfur (2Fe-2S); via pros nitrogenPROSITE-ProRule annotation

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. ubiquinol-cytochrome-c reductase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport

    Keywords - Ligandi

    2Fe-2S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-274-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquinol-cytochrome c reductase iron-sulfur subunit (EC:1.10.2.2)
    Alternative name(s):
    Rieske iron-sulfur protein
    Short name:
    RISP
    Gene namesi
    Name:petA
    Ordered Locus Names:RT0261
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 177177Ubiquinol-cytochrome c reductase iron-sulfur subunitPRO_0000286644Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi125 ↔ 141PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

    Protein-protein interaction databases

    STRINGi257363.RT0261.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68XA0.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini88 – 17588RieskePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Rieske domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0723.
    HOGENOMiHOG000255193.
    KOiK00411.
    OMAiWIINRTD.
    OrthoDBiEOG6RNQD9.

    Family and domain databases

    Gene3Di2.102.10.10. 1 hit.
    InterProiIPR017941. Rieske_2Fe-2S.
    IPR014349. Rieske_Fe-S_prot.
    IPR005805. Rieske_Fe-S_prot_C.
    IPR006311. TAT_signal.
    IPR019546. TAT_signal_bac_arc.
    IPR019470. Ubiq_cytC_Rdtase_Fe-S_su_TAT.
    IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su.
    [Graphical view]
    PANTHERiPTHR10134. PTHR10134. 1 hit.
    PfamiPF00355. Rieske. 1 hit.
    PF10399. UCR_Fe-S_N. 1 hit.
    [Graphical view]
    PRINTSiPR00162. RIESKE.
    SUPFAMiSSF50022. SSF50022. 1 hit.
    TIGRFAMsiTIGR01416. Rieske_proteo. 1 hit.
    TIGR01409. TAT_signal_seq. 1 hit.
    PROSITEiPS51296. RIESKE. 1 hit.
    PS51318. TAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68XA0-1 [UniParc]FASTAAdd to Basket

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    MSDTEDNRNK QTTRRDFIVL TASSVAAVGA ACAFWPIIDS LNPSTDVLAL    50
    SSIEVDLSSI AIGQTVTVKW QGKPIFITNR TPDGIASARA VKMSELIDPE 100
    KDEVRVKAGH DNWLVTIGIC THLGCVPLSN QGEYNGWFCP CHGSQYDSSG 150
    RVRKGPASLN LVVPPYIFIS DTKIRIG 177
    Length:177
    Mass (Da):19,191
    Last modified:October 11, 2004 - v1
    Checksum:i3ADC9B2B6E69DB59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03742.1.
    RefSeqiYP_067224.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03742; AAU03742; RT0261.
    GeneIDi2959250.
    KEGGirty:RT0261.
    PATRICi17909708. VBIRicTyp34752_0270.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03742.1 .
    RefSeqi YP_067224.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68XA0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0261.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03742 ; AAU03742 ; RT0261 .
    GeneIDi 2959250.
    KEGGi rty:RT0261.
    PATRICi 17909708. VBIRicTyp34752_0270.

    Phylogenomic databases

    eggNOGi COG0723.
    HOGENOMi HOG000255193.
    KOi K00411.
    OMAi WIINRTD.
    OrthoDBi EOG6RNQD9.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-274-MONOMER.

    Family and domain databases

    Gene3Di 2.102.10.10. 1 hit.
    InterProi IPR017941. Rieske_2Fe-2S.
    IPR014349. Rieske_Fe-S_prot.
    IPR005805. Rieske_Fe-S_prot_C.
    IPR006311. TAT_signal.
    IPR019546. TAT_signal_bac_arc.
    IPR019470. Ubiq_cytC_Rdtase_Fe-S_su_TAT.
    IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su.
    [Graphical view ]
    PANTHERi PTHR10134. PTHR10134. 1 hit.
    Pfami PF00355. Rieske. 1 hit.
    PF10399. UCR_Fe-S_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00162. RIESKE.
    SUPFAMi SSF50022. SSF50022. 1 hit.
    TIGRFAMsi TIGR01416. Rieske_proteo. 1 hit.
    TIGR01409. TAT_signal_seq. 1 hit.
    PROSITEi PS51296. RIESKE. 1 hit.
    PS51318. TAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiUCRI_RICTY
    AccessioniPrimary (citable) accession number: Q68XA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The Rieske protein is a high potential 2Fe-2S protein.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3