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Q68X73

- MUTS_RICTY

UniProt

Q68X73 - MUTS_RICTY

Protein

DNA mismatch repair protein MutS

Gene

mutS

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    • Comment

    Functioni

    This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi646 – 6538ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. damaged DNA binding Source: UniProtKB-HAMAP
    3. mismatched DNA binding Source: InterPro

    GO - Biological processi

    1. mismatch repair Source: UniProtKB-HAMAP

    Keywords - Biological processi

    DNA damage, DNA repair

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-302-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA mismatch repair protein MutSUniRule annotation
    Gene namesi
    Name:mutSUniRule annotation
    Ordered Locus Names:RT0289
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 891891DNA mismatch repair protein MutSPRO_0000224400Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi257363.RT0289.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68X73.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DNA mismatch repair MutS family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0249.
    HOGENOMiHOG000221406.
    KOiK03555.
    OMAiSICYVDL.
    OrthoDBiEOG6Q5NPV.

    Family and domain databases

    Gene3Di3.30.420.110. 1 hit.
    3.40.1170.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00096. MutS.
    InterProiIPR005748. DNA_mismatch_repair_MutS-1.
    IPR007695. DNA_mismatch_repair_MutS-lik_N.
    IPR000432. DNA_mismatch_repair_MutS_C.
    IPR007861. DNA_mismatch_repair_MutS_clamp.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR016151. DNA_mismatch_repair_MutS_N.
    IPR007860. DNA_mmatch_repair_MutS_con_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01624. MutS_I. 1 hit.
    PF05188. MutS_II. 1 hit.
    PF05192. MutS_III. 1 hit.
    PF05190. MutS_IV. 1 hit.
    PF00488. MutS_V. 1 hit.
    [Graphical view]
    SMARTiSM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    [Graphical view]
    SUPFAMiSSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF53150. SSF53150. 1 hit.
    SSF55271. SSF55271. 1 hit.
    TIGRFAMsiTIGR01070. mutS1. 1 hit.
    PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68X73-1 [UniParc]FASTAAdd to Basket

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    MTLCNMNLYE FRQKYNYDVA TKMMQQYLDI KFAHLDCLLL FRMGDFYELF    50
    YEDAILASNI LGIALTKRGK NCEEEIPMCG VPYHALEHYL TKLITENYKV 100
    AICDQLETPE EAKKRGGYKA VVTRDVTRII TPGTIIEENL ISAAEPNYLT 150
    SLVMTKNKKT ASICYVDLST SKIFIVNVPE TEILNELARL KSREILLSEN 200
    LKSSNLADSI LKQFNCRITY QVDSFFAINK CEKIILDFYK IRDIKGIGEI 250
    SSSQICAIGS ILEYLSLTQK QNIPNLPIPK IINFHSYMTI DFSTRRNLEI 300
    VTNIQGNLHG SVLNTLNHTV TKQGGRLLYH FLSSPLTNIA KINRRLNITE 350
    FFYSNLGIVT RIRELLKNTS DIERCLTRIT MNRSSGRDLL SIKYTLETAK 400
    IINGLFSESH SLNLPNFIGK IIKPLSGDAE LYNLIDMSIR EDAPNNLNDG 450
    GIIKHEFHPK VAQLNDLINN GKLHVEKLKD QYRKETGIDS LKISHNNVLG 500
    LFIDITAKNV NKILDPKFIH RQTTVNSVRY TTYELQNLEN ELVNAQTLVI 550
    SLEKELYTDI CRKVIEKSSY LRILANSLSG LDVFCNFAYI ADEYNYTKPE 600
    FTNDLSFDIV KGRHPVVEAA LLKTSKSFVY NDCHLSEAER ICLITGPNMA 650
    GKSTYLRQNA IITIIAQIGS FVPAKSAKIG VVDKIFSRIG AADDLIKGQS 700
    TFMAEMLETS AILAQSTKNS LIILDEVGRG TSTYDGVSIA WSVLEYIHDK 750
    LKCRCLFATH YHELTVMKNF LPALQNYTIA IEESGKDILF LHNIILGTSN 800
    KSYGLHVAAL AGLPTSVINR AAQILLKFEK ISISKGKNIV STASNNLSLF 850
    NFEPQKHISN SKLDEEFKTI DPDKISPKEA LELIYKFKKL V 891
    Length:891
    Mass (Da):100,714
    Last modified:October 11, 2004 - v1
    Checksum:i3F48D3A78952C6A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03769.1.
    RefSeqiWP_011190754.1. NC_006142.1.
    YP_067251.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03769; AAU03769; RT0289.
    GeneIDi2959018.
    KEGGirty:RT0289.
    PATRICi17909764. VBIRicTyp34752_0297.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03769.1 .
    RefSeqi WP_011190754.1. NC_006142.1.
    YP_067251.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68X73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0289.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03769 ; AAU03769 ; RT0289 .
    GeneIDi 2959018.
    KEGGi rty:RT0289.
    PATRICi 17909764. VBIRicTyp34752_0297.

    Phylogenomic databases

    eggNOGi COG0249.
    HOGENOMi HOG000221406.
    KOi K03555.
    OMAi SICYVDL.
    OrthoDBi EOG6Q5NPV.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-302-MONOMER.

    Family and domain databases

    Gene3Di 3.30.420.110. 1 hit.
    3.40.1170.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00096. MutS.
    InterProi IPR005748. DNA_mismatch_repair_MutS-1.
    IPR007695. DNA_mismatch_repair_MutS-lik_N.
    IPR000432. DNA_mismatch_repair_MutS_C.
    IPR007861. DNA_mismatch_repair_MutS_clamp.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR016151. DNA_mismatch_repair_MutS_N.
    IPR007860. DNA_mmatch_repair_MutS_con_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01624. MutS_I. 1 hit.
    PF05188. MutS_II. 1 hit.
    PF05192. MutS_III. 1 hit.
    PF05190. MutS_IV. 1 hit.
    PF00488. MutS_V. 1 hit.
    [Graphical view ]
    SMARTi SM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF53150. SSF53150. 1 hit.
    SSF55271. SSF55271. 1 hit.
    TIGRFAMsi TIGR01070. mutS1. 1 hit.
    PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiMUTS_RICTY
    AccessioniPrimary (citable) accession number: Q68X73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3