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Q68X73 (MUTS_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA mismatch repair protein MutS
Gene names
Name:mutS
Ordered Locus Names:RT0289
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length891 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity By similarity. HAMAP-Rule MF_00096

Sequence similarities

Belongs to the DNA mismatch repair MutS family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   LigandATP-binding
DNA-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmismatch repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

damaged DNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

mismatched DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 891891DNA mismatch repair protein MutS HAMAP-Rule MF_00096
PRO_0000224400

Regions

Nucleotide binding646 – 6538ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q68X73 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 3F48D3A78952C6A3

FASTA891100,714
        10         20         30         40         50         60 
MTLCNMNLYE FRQKYNYDVA TKMMQQYLDI KFAHLDCLLL FRMGDFYELF YEDAILASNI 

        70         80         90        100        110        120 
LGIALTKRGK NCEEEIPMCG VPYHALEHYL TKLITENYKV AICDQLETPE EAKKRGGYKA 

       130        140        150        160        170        180 
VVTRDVTRII TPGTIIEENL ISAAEPNYLT SLVMTKNKKT ASICYVDLST SKIFIVNVPE 

       190        200        210        220        230        240 
TEILNELARL KSREILLSEN LKSSNLADSI LKQFNCRITY QVDSFFAINK CEKIILDFYK 

       250        260        270        280        290        300 
IRDIKGIGEI SSSQICAIGS ILEYLSLTQK QNIPNLPIPK IINFHSYMTI DFSTRRNLEI 

       310        320        330        340        350        360 
VTNIQGNLHG SVLNTLNHTV TKQGGRLLYH FLSSPLTNIA KINRRLNITE FFYSNLGIVT 

       370        380        390        400        410        420 
RIRELLKNTS DIERCLTRIT MNRSSGRDLL SIKYTLETAK IINGLFSESH SLNLPNFIGK 

       430        440        450        460        470        480 
IIKPLSGDAE LYNLIDMSIR EDAPNNLNDG GIIKHEFHPK VAQLNDLINN GKLHVEKLKD 

       490        500        510        520        530        540 
QYRKETGIDS LKISHNNVLG LFIDITAKNV NKILDPKFIH RQTTVNSVRY TTYELQNLEN 

       550        560        570        580        590        600 
ELVNAQTLVI SLEKELYTDI CRKVIEKSSY LRILANSLSG LDVFCNFAYI ADEYNYTKPE 

       610        620        630        640        650        660 
FTNDLSFDIV KGRHPVVEAA LLKTSKSFVY NDCHLSEAER ICLITGPNMA GKSTYLRQNA 

       670        680        690        700        710        720 
IITIIAQIGS FVPAKSAKIG VVDKIFSRIG AADDLIKGQS TFMAEMLETS AILAQSTKNS 

       730        740        750        760        770        780 
LIILDEVGRG TSTYDGVSIA WSVLEYIHDK LKCRCLFATH YHELTVMKNF LPALQNYTIA 

       790        800        810        820        830        840 
IEESGKDILF LHNIILGTSN KSYGLHVAAL AGLPTSVINR AAQILLKFEK ISISKGKNIV 

       850        860        870        880        890 
STASNNLSLF NFEPQKHISN SKLDEEFKTI DPDKISPKEA LELIYKFKKL V 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU03769.1.
RefSeqYP_067251.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68X73.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0289.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU03769; AAU03769; RT0289.
GeneID2959018.
KEGGrty:RT0289.
PATRIC17909764. VBIRicTyp34752_0297.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0249.
HOGENOMHOG000221406.
KOK03555.
OMAASENDYT.
OrthoDBEOG6Q5NPV.
ProtClustDBPRK05399.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-302-MONOMER.

Family and domain databases

Gene3D3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00096. MutS.
InterProIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsTIGR01070. mutS1. 1 hit.
PROSITEPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMUTS_RICTY
AccessionPrimary (citable) accession number: Q68X73
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names