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Protein

DNA mismatch repair protein MutS

Gene

mutS

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi646 – 6538ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-302-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutSUniRule annotation
Gene namesi
Name:mutSUniRule annotation
Ordered Locus Names:RT0289
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 891891DNA mismatch repair protein MutSPRO_0000224400Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0289.

Structurei

3D structure databases

ProteinModelPortaliQ68X73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0249.
HOGENOMiHOG000221406.
KOiK03555.
OMAiCVTPMGS.
OrthoDBiEOG6Q5NPV.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68X73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLCNMNLYE FRQKYNYDVA TKMMQQYLDI KFAHLDCLLL FRMGDFYELF
60 70 80 90 100
YEDAILASNI LGIALTKRGK NCEEEIPMCG VPYHALEHYL TKLITENYKV
110 120 130 140 150
AICDQLETPE EAKKRGGYKA VVTRDVTRII TPGTIIEENL ISAAEPNYLT
160 170 180 190 200
SLVMTKNKKT ASICYVDLST SKIFIVNVPE TEILNELARL KSREILLSEN
210 220 230 240 250
LKSSNLADSI LKQFNCRITY QVDSFFAINK CEKIILDFYK IRDIKGIGEI
260 270 280 290 300
SSSQICAIGS ILEYLSLTQK QNIPNLPIPK IINFHSYMTI DFSTRRNLEI
310 320 330 340 350
VTNIQGNLHG SVLNTLNHTV TKQGGRLLYH FLSSPLTNIA KINRRLNITE
360 370 380 390 400
FFYSNLGIVT RIRELLKNTS DIERCLTRIT MNRSSGRDLL SIKYTLETAK
410 420 430 440 450
IINGLFSESH SLNLPNFIGK IIKPLSGDAE LYNLIDMSIR EDAPNNLNDG
460 470 480 490 500
GIIKHEFHPK VAQLNDLINN GKLHVEKLKD QYRKETGIDS LKISHNNVLG
510 520 530 540 550
LFIDITAKNV NKILDPKFIH RQTTVNSVRY TTYELQNLEN ELVNAQTLVI
560 570 580 590 600
SLEKELYTDI CRKVIEKSSY LRILANSLSG LDVFCNFAYI ADEYNYTKPE
610 620 630 640 650
FTNDLSFDIV KGRHPVVEAA LLKTSKSFVY NDCHLSEAER ICLITGPNMA
660 670 680 690 700
GKSTYLRQNA IITIIAQIGS FVPAKSAKIG VVDKIFSRIG AADDLIKGQS
710 720 730 740 750
TFMAEMLETS AILAQSTKNS LIILDEVGRG TSTYDGVSIA WSVLEYIHDK
760 770 780 790 800
LKCRCLFATH YHELTVMKNF LPALQNYTIA IEESGKDILF LHNIILGTSN
810 820 830 840 850
KSYGLHVAAL AGLPTSVINR AAQILLKFEK ISISKGKNIV STASNNLSLF
860 870 880 890
NFEPQKHISN SKLDEEFKTI DPDKISPKEA LELIYKFKKL V
Length:891
Mass (Da):100,714
Last modified:October 11, 2004 - v1
Checksum:i3F48D3A78952C6A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03769.1.

Genome annotation databases

EnsemblBacteriaiAAU03769; AAU03769; RT0289.
KEGGirty:RT0289.
PATRICi17909764. VBIRicTyp34752_0297.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03769.1.

3D structure databases

ProteinModelPortaliQ68X73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0289.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU03769; AAU03769; RT0289.
KEGGirty:RT0289.
PATRICi17909764. VBIRicTyp34752_0297.

Phylogenomic databases

eggNOGiCOG0249.
HOGENOMiHOG000221406.
KOiK03555.
OMAiCVTPMGS.
OrthoDBiEOG6Q5NPV.

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-302-MONOMER.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiMUTS_RICTY
AccessioniPrimary (citable) accession number: Q68X73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 11, 2004
Last modified: July 22, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.