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Protein

DNA mismatch repair protein MutS

Gene

mutS

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi646 – 653ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutSUniRule annotation
Gene namesi
Name:mutSUniRule annotation
Ordered Locus Names:RT0289
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000000604 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002244001 – 891DNA mismatch repair protein MutSAdd BLAST891

Proteomic databases

PRIDEiQ68X73

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0289

Structurei

3D structure databases

ProteinModelPortaliQ68X73
SMRiQ68X73
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D86 Bacteria
COG0249 LUCA
HOGENOMiHOG000221406
KOiK03555
OMAiTPMMAQY
OrthoDBiPOG091H0293

Family and domain databases

Gene3Di3.30.420.110, 1 hit
3.40.1170.10, 1 hit
HAMAPiMF_00096 MutS, 1 hit
InterProiView protein in InterPro
IPR005748 DNA_mismatch_repair_MutS
IPR007695 DNA_mismatch_repair_MutS-lik_N
IPR017261 DNA_mismatch_repair_MutS/MSH
IPR000432 DNA_mismatch_repair_MutS_C
IPR007861 DNA_mismatch_repair_MutS_clamp
IPR007696 DNA_mismatch_repair_MutS_core
IPR016151 DNA_mismatch_repair_MutS_N
IPR036187 DNA_mismatch_repair_MutS_sf
IPR007860 DNA_mmatch_repair_MutS_con_dom
IPR036678 MutS_con_dom_sf
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01624 MutS_I, 1 hit
PF05188 MutS_II, 1 hit
PF05192 MutS_III, 1 hit
PF05190 MutS_IV, 1 hit
PF00488 MutS_V, 1 hit
PIRSFiPIRSF037677 DNA_mis_repair_Msh6, 1 hit
SMARTiView protein in SMART
SM00534 MUTSac, 1 hit
SM00533 MUTSd, 1 hit
SUPFAMiSSF48334 SSF48334, 1 hit
SSF52540 SSF52540, 1 hit
SSF53150 SSF53150, 1 hit
SSF55271 SSF55271, 1 hit
TIGRFAMsiTIGR01070 mutS1, 1 hit
PROSITEiView protein in PROSITE
PS00486 DNA_MISMATCH_REPAIR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q68X73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLCNMNLYE FRQKYNYDVA TKMMQQYLDI KFAHLDCLLL FRMGDFYELF
60 70 80 90 100
YEDAILASNI LGIALTKRGK NCEEEIPMCG VPYHALEHYL TKLITENYKV
110 120 130 140 150
AICDQLETPE EAKKRGGYKA VVTRDVTRII TPGTIIEENL ISAAEPNYLT
160 170 180 190 200
SLVMTKNKKT ASICYVDLST SKIFIVNVPE TEILNELARL KSREILLSEN
210 220 230 240 250
LKSSNLADSI LKQFNCRITY QVDSFFAINK CEKIILDFYK IRDIKGIGEI
260 270 280 290 300
SSSQICAIGS ILEYLSLTQK QNIPNLPIPK IINFHSYMTI DFSTRRNLEI
310 320 330 340 350
VTNIQGNLHG SVLNTLNHTV TKQGGRLLYH FLSSPLTNIA KINRRLNITE
360 370 380 390 400
FFYSNLGIVT RIRELLKNTS DIERCLTRIT MNRSSGRDLL SIKYTLETAK
410 420 430 440 450
IINGLFSESH SLNLPNFIGK IIKPLSGDAE LYNLIDMSIR EDAPNNLNDG
460 470 480 490 500
GIIKHEFHPK VAQLNDLINN GKLHVEKLKD QYRKETGIDS LKISHNNVLG
510 520 530 540 550
LFIDITAKNV NKILDPKFIH RQTTVNSVRY TTYELQNLEN ELVNAQTLVI
560 570 580 590 600
SLEKELYTDI CRKVIEKSSY LRILANSLSG LDVFCNFAYI ADEYNYTKPE
610 620 630 640 650
FTNDLSFDIV KGRHPVVEAA LLKTSKSFVY NDCHLSEAER ICLITGPNMA
660 670 680 690 700
GKSTYLRQNA IITIIAQIGS FVPAKSAKIG VVDKIFSRIG AADDLIKGQS
710 720 730 740 750
TFMAEMLETS AILAQSTKNS LIILDEVGRG TSTYDGVSIA WSVLEYIHDK
760 770 780 790 800
LKCRCLFATH YHELTVMKNF LPALQNYTIA IEESGKDILF LHNIILGTSN
810 820 830 840 850
KSYGLHVAAL AGLPTSVINR AAQILLKFEK ISISKGKNIV STASNNLSLF
860 870 880 890
NFEPQKHISN SKLDEEFKTI DPDKISPKEA LELIYKFKKL V
Length:891
Mass (Da):100,714
Last modified:October 11, 2004 - v1
Checksum:i3F48D3A78952C6A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA Translation: AAU03769.1

Genome annotation databases

EnsemblBacteriaiAAU03769; AAU03769; RT0289
KEGGirty:RT0289

Similar proteinsi

Entry informationi

Entry nameiMUTS_RICTY
AccessioniPrimary (citable) accession number: Q68X73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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