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Q68X51

- LPXB_RICTY

UniProt

Q68X51 - LPXB_RICTY

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-326-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:RT0311
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Lipid-A-disaccharide synthasePRO_0000255219Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0311.

Structurei

3D structure databases

ProteinModelPortaliQ68X51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiIARMLVN.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68X51-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKIYFIAGE MSGDFIGGHI IQNLKSNEGL EFTGIGGQYM EEAGNFKSLF
60 70 80 90 100
TITAINFIGF IEIIPHLLKI KKLIDKTVEN IINSKVDLLI TIDSPGFTYR
110 120 130 140 150
VAKRVRKFLP NLKIIHIVAP SVWAYKAGRA VDYAKIYDCL FALLPFEPPY
160 170 180 190 200
FTKVGLDCRY IGHPILEQEF YRDKIALRKE FKIDDNESIL CVTFGTRKGE
210 220 230 240 250
ILRHLPIFIT AIQKISKDYK NLRIIFPLVH PDHEAIIKPF LENVQFNYLF
260 270 280 290 300
LSSERLKAYA VSDLALAKSG TNTLEISASG TPMVVAYKVN IISFFIIMFL
310 320 330 340 350
IKIKYVSLIN IMAGSAIIPE FIQFNCRANL ISNKLKELLS NSQKRDNQVV
360 370 380
ESQKILQKLR FASDRSPSYI AAKIIKQEFL
Length:380
Mass (Da):43,320
Last modified:October 11, 2004 - v1
Checksum:iE55063452071B13F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03791.1.
RefSeqiYP_067273.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03791; AAU03791; RT0311.
GeneIDi2958828.
KEGGirty:RT0311.
PATRICi17909814. VBIRicTyp34752_0322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03791.1 .
RefSeqi YP_067273.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68X51.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0311.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03791 ; AAU03791 ; RT0311 .
GeneIDi 2958828.
KEGGi rty:RT0311.
PATRICi 17909814. VBIRicTyp34752_0322.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi IARMLVN.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci RTYP257363:GJEQ-326-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiLPXB_RICTY
AccessioniPrimary (citable) accession number: Q68X51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3