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Q68X51

- LPXB_RICTY

UniProt

Q68X51 - LPXB_RICTY

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-326-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:RT0311
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 380380Lipid-A-disaccharide synthasePRO_0000255219Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi257363.RT0311.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68X51.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiIARMLVN.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q68X51-1 [UniParc]FASTAAdd to Basket

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    MKKIYFIAGE MSGDFIGGHI IQNLKSNEGL EFTGIGGQYM EEAGNFKSLF    50
    TITAINFIGF IEIIPHLLKI KKLIDKTVEN IINSKVDLLI TIDSPGFTYR 100
    VAKRVRKFLP NLKIIHIVAP SVWAYKAGRA VDYAKIYDCL FALLPFEPPY 150
    FTKVGLDCRY IGHPILEQEF YRDKIALRKE FKIDDNESIL CVTFGTRKGE 200
    ILRHLPIFIT AIQKISKDYK NLRIIFPLVH PDHEAIIKPF LENVQFNYLF 250
    LSSERLKAYA VSDLALAKSG TNTLEISASG TPMVVAYKVN IISFFIIMFL 300
    IKIKYVSLIN IMAGSAIIPE FIQFNCRANL ISNKLKELLS NSQKRDNQVV 350
    ESQKILQKLR FASDRSPSYI AAKIIKQEFL 380
    Length:380
    Mass (Da):43,320
    Last modified:October 11, 2004 - v1
    Checksum:iE55063452071B13F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03791.1.
    RefSeqiYP_067273.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03791; AAU03791; RT0311.
    GeneIDi2958828.
    KEGGirty:RT0311.
    PATRICi17909814. VBIRicTyp34752_0322.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03791.1 .
    RefSeqi YP_067273.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68X51.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0311.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03791 ; AAU03791 ; RT0311 .
    GeneIDi 2958828.
    KEGGi rty:RT0311.
    PATRICi 17909814. VBIRicTyp34752_0322.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi IARMLVN.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci RTYP257363:GJEQ-326-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiLPXB_RICTY
    AccessioniPrimary (citable) accession number: Q68X51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3