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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei243ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRTYP257363:G1G0L-321-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:RT0316
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000000604 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001196421 – 448Glutamate--tRNA ligase 1Add BLAST448

Proteomic databases

PRIDEiQ68X46

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0316

Structurei

3D structure databases

ProteinModelPortaliQ68X46
SMRiQ68X46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 20"HIGH" regionUniRule annotationAdd BLAST11
Motifi240 – 244"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252721
KOiK01885
OMAiLYPCYET
OrthoDBiPOG091H021W

Family and domain databases

Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q68X46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKVITRFAP SPTGMLHVGN IRVALLNWLY AKKHNGKFIL RFDDTDLERS
60 70 80 90 100
KQKYKNDIER DLKFLNINCD QIFNQLSRVS RYNEIKNLLI NKKRLYACYE
110 120 130 140 150
TTEELELKRK FRLSKGLPPI YDRASLNLTE KQIQKYIEQG RKPHYRFFLN
160 170 180 190 200
DEPISWYDMI KGDIKYNGKA LSDPIVIRAD GSMTYMLCSV IDDIDYDITH
210 220 230 240 250
IIRGEDHVSN TAIQIQMFEA LNKIPPVFAH LSLIINKEEK ISKRVGGFEI
260 270 280 290 300
AYLKNEVGLE AMTITSFFSL LGSSLHIFPY KSIEKLVAQF EISSFSKSPT
310 320 330 340 350
IYQQYDLERL NHKLLISLDY HEVKERLKEI NADYIDENFW LSVRANLQKL
360 370 380 390 400
SDIKDWWDIC YQTPKIGNLN LDKEYLKQAS ELLPLGKITK DSWSIWTKEI
410 420 430 440
TNATGRKGKE LFLPIRLALT GRKSGPEIAG ILPLLKREEI IKRLVAIT
Length:448
Mass (Da):52,196
Last modified:October 11, 2004 - v1
Checksum:i511D8B867F9B97E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA Translation: AAU03796.1
RefSeqiWP_011190780.1, NC_006142.1

Genome annotation databases

EnsemblBacteriaiAAU03796; AAU03796; RT0316
KEGGirty:RT0316

Similar proteinsi

Entry informationi

Entry nameiSYE1_RICTY
AccessioniPrimary (citable) accession number: Q68X46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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