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Q68X19 (NUOD_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit D

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit D
NDH-1 subunit D
Gene names
Name:nuoD
Ordered Locus Names:RT0343
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP-Rule MF_01358

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP-Rule MF_01358

Subunit structure

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex By similarity.

Subcellular location

Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity HAMAP-Rule MF_01358.

Sequence similarities

Belongs to the complex I 49 kDa subunit family.

Sequence caution

The sequence AAU03823.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

NADH dehydrogenase (quinone) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389NADH-quinone oxidoreductase subunit D HAMAP-Rule MF_01358
PRO_0000287865

Sequences

Sequence LengthMass (Da)Tools
Q68X19 [UniParc].

Last modified May 15, 2007. Version 2.
Checksum: 3FACF9E0E740F877

FASTA38944,469
        10         20         30         40         50         60 
MTNKTITLNL GPQHPATHGV LRLILEMDGE VVNNADPHIG LLHRGTEKLI EHKTYLQAIP 

        70         80         90        100        110        120 
YFDRLDYVSP MCQEHAFALA VESLLECSVP RRAQFIRVLF SELTRILNHT LNIGSQALDI 

       130        140        150        160        170        180 
GATTPLLWLF EEREKIMEFY ERVSGSRMHA NYFRPGGVAE DLPEKLLEDI NKFIEQFPSK 

       190        200        210        220        230        240 
LNDIENLLNE NRLWKQRLVD IGVVSQKDAM DWGFSGPMLR GSGIAWDLRK SNPYDVYDEM 

       250        260        270        280        290        300 
DFEVPVGKNG DCYDRYLVRI LEMYESIKII KQCIAKMPKG QVKTDNPKLT PPTREKMKES 

       310        320        330        340        350        360 
MEAMIHHFKL YTEGYDVPIG ETYKAVEAPK GEFGVYLYSQ GGNKPYRCRI KAPGFAHLQG 

       370        380 
LNFMSKGHLI SDVITIIATL DIVFGEIDR 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU03823.1. Different initiation.
RefSeqYP_067305.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68X19.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0343.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU03823; AAU03823; RT0343.
GeneID2958534.
KEGGrty:RT0343.
PATRIC17909890. VBIRicTyp34752_0360.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0649.
HOGENOMHOG000228264.
KOK00333.
OMAEYRTWTQ.
OrthoDBEOG62G5MP.
ProtClustDBPRK06075.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-360-MONOMER.

Family and domain databases

HAMAPMF_01358. NDH1_NuoD.
InterProIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
[Graphical view]
PfamPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
TIGRFAMsTIGR01962. NuoD. 1 hit.
PROSITEPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOD_RICTY
AccessionPrimary (citable) accession number: Q68X19
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: February 19, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names