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Protein

NADH-quinone oxidoreductase subunit D

Gene

nuoD

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. NADH dehydrogenase (quinone) activity Source: UniProtKB-HAMAP
  3. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-360-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit DUniRule annotation (EC:1.6.99.5UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit DUniRule annotation
NDH-1 subunit DUniRule annotation
Gene namesi
Name:nuoDUniRule annotation
Ordered Locus Names:RT0343
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389NADH-quinone oxidoreductase subunit DPRO_0000287865Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0343.

Structurei

3D structure databases

ProteinModelPortaliQ68X19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0649.
HOGENOMiHOG000228264.
KOiK00333.
OMAiEYRTWTQ.
OrthoDBiEOG62G5MP.

Family and domain databases

Gene3Di1.10.645.10. 1 hit.
HAMAPiMF_01358. NDH1_NuoD.
InterProiIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
SUPFAMiSSF56762. SSF56762. 1 hit.
TIGRFAMsiTIGR01962. NuoD. 1 hit.
PROSITEiPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68X19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNKTITLNL GPQHPATHGV LRLILEMDGE VVNNADPHIG LLHRGTEKLI
60 70 80 90 100
EHKTYLQAIP YFDRLDYVSP MCQEHAFALA VESLLECSVP RRAQFIRVLF
110 120 130 140 150
SELTRILNHT LNIGSQALDI GATTPLLWLF EEREKIMEFY ERVSGSRMHA
160 170 180 190 200
NYFRPGGVAE DLPEKLLEDI NKFIEQFPSK LNDIENLLNE NRLWKQRLVD
210 220 230 240 250
IGVVSQKDAM DWGFSGPMLR GSGIAWDLRK SNPYDVYDEM DFEVPVGKNG
260 270 280 290 300
DCYDRYLVRI LEMYESIKII KQCIAKMPKG QVKTDNPKLT PPTREKMKES
310 320 330 340 350
MEAMIHHFKL YTEGYDVPIG ETYKAVEAPK GEFGVYLYSQ GGNKPYRCRI
360 370 380
KAPGFAHLQG LNFMSKGHLI SDVITIIATL DIVFGEIDR
Length:389
Mass (Da):44,469
Last modified:May 15, 2007 - v2
Checksum:i3FACF9E0E740F877
GO

Sequence cautioni

The sequence AAU03823.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03823.1. Different initiation.
RefSeqiYP_067305.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03823; AAU03823; RT0343.
GeneIDi2958534.
KEGGirty:RT0343.
PATRICi17909890. VBIRicTyp34752_0360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03823.1. Different initiation.
RefSeqiYP_067305.1. NC_006142.1.

3D structure databases

ProteinModelPortaliQ68X19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0343.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU03823; AAU03823; RT0343.
GeneIDi2958534.
KEGGirty:RT0343.
PATRICi17909890. VBIRicTyp34752_0360.

Phylogenomic databases

eggNOGiCOG0649.
HOGENOMiHOG000228264.
KOiK00333.
OMAiEYRTWTQ.
OrthoDBiEOG62G5MP.

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-360-MONOMER.

Family and domain databases

Gene3Di1.10.645.10. 1 hit.
HAMAPiMF_01358. NDH1_NuoD.
InterProiIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
SUPFAMiSSF56762. SSF56762. 1 hit.
TIGRFAMsiTIGR01962. NuoD. 1 hit.
PROSITEiPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiNUOD_RICTY
AccessioniPrimary (citable) accession number: Q68X19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: January 7, 2015
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.