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Protein

NADH-quinone oxidoreductase subunit C

Gene

nuoC

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processTransport
LigandNAD, Ubiquinone

Enzyme and pathway databases

BioCyciRTYP257363:G1G0L-350-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit CUniRule annotation (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit CUniRule annotation
NDH-1 subunit CUniRule annotation
Gene namesi
Name:nuoCUniRule annotation
Ordered Locus Names:RT0344
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000000604 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002878601 – 197NADH-quinone oxidoreductase subunit CAdd BLAST197

Keywords - PTMi

Quinone

Proteomic databases

PRIDEiQ68X18

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0344

Structurei

3D structure databases

ProteinModelPortaliQ68X18
SMRiQ68X18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 30 kDa subunit family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CYU Bacteria
COG0852 LUCA
HOGENOMiHOG000009797
KOiK00332
OMAiYTQVKYD
OrthoDBiPOG091H0976

Family and domain databases

Gene3Di3.30.460.80, 1 hit
HAMAPiMF_01357 NDH1_NuoC, 1 hit
InterProiView protein in InterPro
IPR010218 NADH_DH_suC
IPR037232 NADH_quin_OxRdtase_su_C/D-like
IPR001268 NADH_UbQ_OxRdtase_30kDa_su
PfamiView protein in Pfam
PF00329 Complex1_30kDa, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001581 NADH_UbQ_OxRdtase_30kDa_su, 1 hit
SUPFAMiSSF143243 SSF143243, 1 hit
TIGRFAMsiTIGR01961 NuoC_fam, 1 hit

Sequencei

Sequence statusi: Complete.

Q68X18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLDELIDKL AAKSRILITK VTVKDHLAYK IEPHFLLPFL KALKESEELR
60 70 80 90 100
FTVLTDLFGV DFPKREKRFE IVYNLLSLKL NKNLIIKTNI SEKESIPSAM
110 120 130 140 150
KILSAACWYE LEVYDMYGVN FNGNNDKRRI LTDYDFEGHP LRKDFPLTGY
160 170 180 190
TQVKYDKKLK KIAYEPVNLD IEYREFDFSS HWHSPSYILP GDEKAEK
Length:197
Mass (Da):23,175
Last modified:October 11, 2004 - v1
Checksum:i067E7E6D0FB2EBB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA Translation: AAU03824.1
RefSeqiWP_011190808.1, NC_006142.1

Genome annotation databases

EnsemblBacteriaiAAU03824; AAU03824; RT0344
KEGGirty:RT0344

Similar proteinsi

Entry informationi

Entry nameiNUOC_RICTY
AccessioniPrimary (citable) accession number: Q68X18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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