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Q68X18

- NUOC_RICTY

UniProt

Q68X18 - NUOC_RICTY

Protein

NADH-quinone oxidoreductase subunit C

Gene

nuoC

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    2. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-361-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit CUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit CUniRule annotation
    NDH-1 subunit CUniRule annotation
    Gene namesi
    Name:nuoCUniRule annotation
    Ordered Locus Names:RT0344
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 197197NADH-quinone oxidoreductase subunit CPRO_0000287860Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi257363.RT0344.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68X18.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 30 kDa subunit family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0852.
    HOGENOMiHOG000009797.
    KOiK00332.
    OMAiYTQVKYD.
    OrthoDBiEOG60PHFK.

    Family and domain databases

    HAMAPiMF_01357. NDH1_NuoC.
    InterProiIPR010218. NADH_DH_suC.
    IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
    [Graphical view]
    PfamiPF00329. Complex1_30kDa. 1 hit.
    [Graphical view]
    ProDomiPD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    TIGRFAMsiTIGR01961. NuoC_fam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q68X18-1 [UniParc]FASTAAdd to Basket

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    MTLDELIDKL AAKSRILITK VTVKDHLAYK IEPHFLLPFL KALKESEELR    50
    FTVLTDLFGV DFPKREKRFE IVYNLLSLKL NKNLIIKTNI SEKESIPSAM 100
    KILSAACWYE LEVYDMYGVN FNGNNDKRRI LTDYDFEGHP LRKDFPLTGY 150
    TQVKYDKKLK KIAYEPVNLD IEYREFDFSS HWHSPSYILP GDEKAEK 197
    Length:197
    Mass (Da):23,175
    Last modified:October 11, 2004 - v1
    Checksum:i067E7E6D0FB2EBB4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03824.1.
    RefSeqiYP_067306.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03824; AAU03824; RT0344.
    GeneIDi2958529.
    KEGGirty:RT0344.
    PATRICi17909892. VBIRicTyp34752_0361.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03824.1 .
    RefSeqi YP_067306.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68X18.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0344.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03824 ; AAU03824 ; RT0344 .
    GeneIDi 2958529.
    KEGGi rty:RT0344.
    PATRICi 17909892. VBIRicTyp34752_0361.

    Phylogenomic databases

    eggNOGi COG0852.
    HOGENOMi HOG000009797.
    KOi K00332.
    OMAi YTQVKYD.
    OrthoDBi EOG60PHFK.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-361-MONOMER.

    Family and domain databases

    HAMAPi MF_01357. NDH1_NuoC.
    InterProi IPR010218. NADH_DH_suC.
    IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
    [Graphical view ]
    Pfami PF00329. Complex1_30kDa. 1 hit.
    [Graphical view ]
    ProDomi PD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    TIGRFAMsi TIGR01961. NuoC_fam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiNUOC_RICTY
    AccessioniPrimary (citable) accession number: Q68X18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3