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Q68X18

- NUOC_RICTY

UniProt

Q68X18 - NUOC_RICTY

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Protein
NADH-quinone oxidoreductase subunit C
Gene
nuoC, RT0344
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  2. quinone binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-361-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit C (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I subunit C
NDH-1 subunit C
Gene namesi
Name:nuoC
Ordered Locus Names:RT0344
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197NADH-quinone oxidoreductase subunit CUniRule annotation
PRO_0000287860Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex By similarity.

Protein-protein interaction databases

STRINGi257363.RT0344.

Structurei

3D structure databases

ProteinModelPortaliQ68X18.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0852.
HOGENOMiHOG000009797.
KOiK00332.
OMAiYTQVKYD.
OrthoDBiEOG60PHFK.

Family and domain databases

HAMAPiMF_01357. NDH1_NuoC.
InterProiIPR010218. NADH_DH_suC.
IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
[Graphical view]
PfamiPF00329. Complex1_30kDa. 1 hit.
[Graphical view]
ProDomiPD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR01961. NuoC_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68X18-1 [UniParc]FASTAAdd to Basket

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MTLDELIDKL AAKSRILITK VTVKDHLAYK IEPHFLLPFL KALKESEELR    50
FTVLTDLFGV DFPKREKRFE IVYNLLSLKL NKNLIIKTNI SEKESIPSAM 100
KILSAACWYE LEVYDMYGVN FNGNNDKRRI LTDYDFEGHP LRKDFPLTGY 150
TQVKYDKKLK KIAYEPVNLD IEYREFDFSS HWHSPSYILP GDEKAEK 197
Length:197
Mass (Da):23,175
Last modified:October 11, 2004 - v1
Checksum:i067E7E6D0FB2EBB4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03824.1.
RefSeqiYP_067306.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03824; AAU03824; RT0344.
GeneIDi2958529.
KEGGirty:RT0344.
PATRICi17909892. VBIRicTyp34752_0361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03824.1 .
RefSeqi YP_067306.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68X18.
ModBasei Search...

Protein-protein interaction databases

STRINGi 257363.RT0344.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03824 ; AAU03824 ; RT0344 .
GeneIDi 2958529.
KEGGi rty:RT0344.
PATRICi 17909892. VBIRicTyp34752_0361.

Phylogenomic databases

eggNOGi COG0852.
HOGENOMi HOG000009797.
KOi K00332.
OMAi YTQVKYD.
OrthoDBi EOG60PHFK.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-361-MONOMER.

Family and domain databases

HAMAPi MF_01357. NDH1_NuoC.
InterProi IPR010218. NADH_DH_suC.
IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
[Graphical view ]
Pfami PF00329. Complex1_30kDa. 1 hit.
[Graphical view ]
ProDomi PD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
TIGRFAMsi TIGR01961. NuoC_fam. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiNUOC_RICTY
AccessioniPrimary (citable) accession number: Q68X18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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