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Reviewed, UniProtKB/Swiss-Prot Q68X16 (NUOA_RICTY)

Last modified November 25, 2008. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    NADH-quinone oxidoreductase subunit A
    EC=1.6.99.5
Alternative name(s):
    NADH dehydrogenase I subunit A
    NDH-1 subunit A
Gene names
Name: nuoA
Ordered Locus Names: RT0346
OrganismRickettsia typhi [Complete proteome] [HAMAP]
Taxonomic identifier785 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length123 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.

Catalytic activity

NADH + quinone = NAD(+) + quinol.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the complex I subunit 3 family.

Ontologies

Keywords

   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   LigandNAD
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processmitochondrial electron transport, NADH to ubiquinone

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionNADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: InterPro

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 123123NADH-quinone oxidoreductase subunit A
PRO_0000271222

Regions

Transmembrane11 – 3121 Potential
Transmembrane68 – 8821 Potential
Transmembrane93 – 11321 Potential

Sequences

Sequence LengthMass (Da)Tools
Q68X16-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: C2FABB65DD99A125

FASTA12314,267
        10         20         30         40         50         60 
MLQNSELLHE YLPIAIFFGI AVLVSGLIMM LPNLLSTKKY NKDKLEPYEC GFAPFSDARS 

        70         80         90        100        110        120 
KFDIRFYLVA ILFIIFDLEI TFLVPWAISL NTIGKIGFFS MMFFLFVLII GFIYEWTKGA 


LDW 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

AE017197 Genomic DNA. Translation: AAU03826.1.
RefSeqYP_067308.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2958504.
GenomeReviewsGene locus RT0346 in contig AE017197_GR.
KEGGrty:RT0346.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ68X16.

Enzyme and pathway databases

BioCycRTYP257363:RT0346-MON.

Family and domain databases

InterProIPR000440. Oxidored_q4.
[Graphical view]
PANTHERPTHR11058. Oxidored_q4. 1 hit.
PfamPF00507. Oxidored_q4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOA_RICTY
AccessionPrimary (citable) accession number: Q68X16
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 11, 2004
Last modified: November 25, 2008
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents