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Q68X16

- NUOA_RICTY

UniProt

Q68X16 - NUOA_RICTY

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Protein

NADH-quinone oxidoreductase subunit A

Gene

nuoA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-363-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit AUniRule annotation (EC:1.6.99.5UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit AUniRule annotation
NDH-1 subunit AUniRule annotation
NUO1UniRule annotation
Gene namesi
Name:nuoAUniRule annotation
Ordered Locus Names:RT0346
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalUniRule annotationAdd
BLAST
Transmembranei68 – 8821HelicalUniRule annotationAdd
BLAST
Transmembranei93 – 11321HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 123123NADH-quinone oxidoreductase subunit APRO_0000271222Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0346.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 3 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0838.
HOGENOMiHOG000100119.
KOiK00330.
OMAiSTYECGF.
OrthoDBiEOG6QVRQ6.

Family and domain databases

HAMAPiMF_01394. NDH1_NuoA.
InterProiIPR023043. NAD(P)H_OxRDtase_bac/plastid.
IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
[Graphical view]
PANTHERiPTHR11058. PTHR11058. 1 hit.
PfamiPF00507. Oxidored_q4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68X16-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLQNSELLHE YLPIAIFFGI AVLVSGLIMM LPNLLSTKKY NKDKLEPYEC
60 70 80 90 100
GFAPFSDARS KFDIRFYLVA ILFIIFDLEI TFLVPWAISL NTIGKIGFFS
110 120
MMFFLFVLII GFIYEWTKGA LDW
Length:123
Mass (Da):14,267
Last modified:October 11, 2004 - v1
Checksum:iC2FABB65DD99A125
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03826.1.
RefSeqiYP_067308.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03826; AAU03826; RT0346.
GeneIDi2958504.
KEGGirty:RT0346.
PATRICi17909896. VBIRicTyp34752_0363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03826.1 .
RefSeqi YP_067308.1. NC_006142.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0346.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03826 ; AAU03826 ; RT0346 .
GeneIDi 2958504.
KEGGi rty:RT0346.
PATRICi 17909896. VBIRicTyp34752_0363.

Phylogenomic databases

eggNOGi COG0838.
HOGENOMi HOG000100119.
KOi K00330.
OMAi STYECGF.
OrthoDBi EOG6QVRQ6.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-363-MONOMER.

Family and domain databases

HAMAPi MF_01394. NDH1_NuoA.
InterProi IPR023043. NAD(P)H_OxRDtase_bac/plastid.
IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
[Graphical view ]
PANTHERi PTHR11058. PTHR11058. 1 hit.
Pfami PF00507. Oxidored_q4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiNUOA_RICTY
AccessioniPrimary (citable) accession number: Q68X16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3