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Q68X10

- FABI_RICTY

UniProt

Q68X10 - FABI_RICTY

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Protein

Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

Gene

fabI

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity).By similarity

Catalytic activityi

An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151NAD; via carbonyl oxygenBy similarity
Binding sitei42 – 421NADBy similarity
Binding sitei94 – 941NAD; via carbonyl oxygenBy similarity
Binding sitei97 – 971Substrate; via amide nitrogen and carbonyl oxygenBy similarity
Active sitei147 – 1471Proton acceptorBy similarity
Active sitei157 – 1571Proton acceptorBy similarity
Binding sitei164 – 1641NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 222NADBy similarity
Nucleotide bindingi66 – 672NADBy similarity
Nucleotide bindingi193 – 1975NADBy similarity

GO - Molecular functioni

  1. enoyl-[acyl-carrier-protein] reductase (NADH) activity Source: UniProtKB

GO - Biological processi

  1. fatty acid elongation Source: UniProtKB
  2. protein homotetramerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-370-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (EC:1.3.1.9)
Short name:
ENR
Alternative name(s):
NADH-dependent enoyl-ACP reductase
Gene namesi
Name:fabI
Ordered Locus Names:RT0353
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Enoyl-[acyl-carrier-protein] reductase [NADH] FabIPRO_0000286637Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi257363.RT0353.

Structurei

3D structure databases

ProteinModelPortaliQ68X10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0623.
KOiK00208.
OMAiTGEIHHV.
OrthoDBiEOG6HF644.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PIRSFiPIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSiPR00081. GDHRDH.

Sequencei

Sequence statusi: Complete.

Q68X10-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTRLLQGKK GLITGIANNM SISWAIAQLA KKHGAELWFT YQSEALEKRV
60 70 80 90 100
KPLAEEIGCN FISELDVTDQ KSISNLFNDI KEKWNSFDFL LHGMAFANKN
110 120 130 140 150
ELKGRYVDTS LENFYNSLHI SCYSLLELSR SAETLMHDGG SILTLTYYGA
160 170 180 190 200
EKVIPNYNIM GVAKAALEAS VKYLANDMGE NNIRVNAISA GPIKTLASSA
210 220 230 240 250
ISDFSTMLKF HASTAPLKRN ITQEDVGGAA VYLFSELSKG VTGEIHYVDC
260
GYNIIGSSKL L
Length:261
Mass (Da):28,713
Last modified:October 11, 2004 - v1
Checksum:i45A3A9D3F0E6DF9F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03832.1.
RefSeqiYP_067314.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03832; AAU03832; RT0353.
GeneIDi2958632.
KEGGirty:RT0353.
PATRICi17909910. VBIRicTyp34752_0369.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03832.1 .
RefSeqi YP_067314.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68X10.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0353.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03832 ; AAU03832 ; RT0353 .
GeneIDi 2958632.
KEGGi rty:RT0353.
PATRICi 17909910. VBIRicTyp34752_0369.

Phylogenomic databases

eggNOGi COG0623.
KOi K00208.
OMAi TGEIHHV.
OrthoDBi EOG6HF644.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci RTYP257363:GJEQ-370-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PIRSFi PIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSi PR00081. GDHRDH.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiFABI_RICTY
AccessioniPrimary (citable) accession number: Q68X10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3