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Q68X10 (FABI_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

Short name=ENR
EC=1.3.1.9
Alternative name(s):
NADH-dependent enoyl-ACP reductase
Gene names
Name:fabI
Ordered Locus Names:RT0353
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism By similarity.

Catalytic activity

An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
PRO_0000286637

Regions

Nucleotide binding21 – 222NAD By similarity
Nucleotide binding66 – 672NAD By similarity
Nucleotide binding193 – 1975NAD By similarity

Sites

Active site1471Proton acceptor By similarity
Active site1571Proton acceptor By similarity
Binding site151NAD; via carbonyl oxygen By similarity
Binding site421NAD By similarity
Binding site941NAD; via carbonyl oxygen By similarity
Binding site971Substrate; via amide nitrogen and carbonyl oxygen By similarity
Binding site1641NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68X10 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 45A3A9D3F0E6DF9F

FASTA26128,713
        10         20         30         40         50         60 
MTTRLLQGKK GLITGIANNM SISWAIAQLA KKHGAELWFT YQSEALEKRV KPLAEEIGCN 

        70         80         90        100        110        120 
FISELDVTDQ KSISNLFNDI KEKWNSFDFL LHGMAFANKN ELKGRYVDTS LENFYNSLHI 

       130        140        150        160        170        180 
SCYSLLELSR SAETLMHDGG SILTLTYYGA EKVIPNYNIM GVAKAALEAS VKYLANDMGE 

       190        200        210        220        230        240 
NNIRVNAISA GPIKTLASSA ISDFSTMLKF HASTAPLKRN ITQEDVGGAA VYLFSELSKG 

       250        260 
VTGEIHYVDC GYNIIGSSKL L 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU03832.1.
RefSeqYP_067314.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68X10.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0353.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU03832; AAU03832; RT0353.
GeneID2958632.
KEGGrty:RT0353.
PATRIC17909910. VBIRicTyp34752_0369.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0623.
KOK00208.
OMATGEIHHV.
OrthoDBEOG6HF644.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-370-MONOMER.
UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PIRSFPIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSPR00081. GDHRDH.
ProtoNetSearch...

Entry information

Entry nameFABI_RICTY
AccessionPrimary (citable) accession number: Q68X10
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways