Reviewed, UniProtKB/Swiss-Prot Q68X10 (FABI_RICTY)

Names and origin

Protein names

Recommended name:
    Enoyl-[acyl-carrier-protein] reductase [NADH]
    EC=1.3.1.9
Alternative name(s):
    NADH-dependent enoyl-ACP reductase

Gene names

Name:	fabI
Ordered Locus Names:	RT0353

Organism

Rickettsia typhi [Complete proteome] [HAMAP]

Taxonomic identifier

785 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acyl-[acyl-carrier-protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro enoyl-[acyl-carrier-protein] reductase (NADH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Enoyl-[acyl-carrier-protein] reductase [NADH]		PRO_0000286637
Regions
	Nucleotide binding	12 – 38	27	NAD By similarity
Sites
	Active site	157	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q68X10-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 45A3A9D3F0E6DF9F	FASTA	261	28,713
	10 20 30 40 50 60 MTTRLLQGKK GLITGIANNM SISWAIAQLA KKHGAELWFT YQSEALEKRV KPLAEEIGCN 70 80 90 100 110 120 FISELDVTDQ KSISNLFNDI KEKWNSFDFL LHGMAFANKN ELKGRYVDTS LENFYNSLHI 130 140 150 160 170 180 SCYSLLELSR SAETLMHDGG SILTLTYYGA EKVIPNYNIM GVAKAALEAS VKYLANDMGE 190 200 210 220 230 240 NNIRVNAISA GPIKTLASSA ISDFSTMLKF HASTAPLKRN ITQEDVGGAA VYLFSELSKG 250 260 VTGEIHYVDC GYNIIGSSKL L

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017197 Genomic DNA. Translation: AAU03832.1.
RefSeq	YP_067314.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2958632.
GenomeReviews	Gene locus RT0353 in contig AE017197_GR.
KEGG	rty:RT0353.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q68X10.
OMA	Q68X10. LVHCLAF.
Enzyme and pathway databases
BioCyc	RTYP257363:RT0353-MON.
BRENDA	1.3.1.9. 281221.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR014358. Enoyl-ACP_Rdtase_NADH. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit. PTHR19410:SF12. Enoyl-ACP_rdct. 1 hit.
PRINTS	PR00081. GDHRDH.
ProtoNet	Search...

Entry information

Entry name

FABI_RICTY

Accession

Primary (citable) accession number: Q68X10

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	October 11, 2004
Last modified:	June 16, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)