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Q68X04

- SYK_RICTY

UniProt

Q68X04 - SYK_RICTY

Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei293 – 2931ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. lysine-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. lysyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-376-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
    Alternative name(s):
    Lysyl-tRNA synthetaseUniRule annotation
    Short name:
    LysRSUniRule annotation
    Gene namesi
    Name:lysSUniRule annotation
    Ordered Locus Names:RT0359
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 526526Lysine--tRNA ligasePRO_0000278076Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi257363.RT0359.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68X04.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi44 – 529"HIGH" region
    Motifi290 – 2945"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1384.
    HOGENOMiHOG000140447.
    KOiK04566.
    OMAiTMVRHAF.
    OrthoDBiEOG6WHNM6.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00177. Lys_tRNA_synth_class1.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR002904. Lys-tRNA-ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF01921. tRNA-synt_1f. 1 hit.
    [Graphical view]
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00467. lysS_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68X04-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVIWKDAIR SNAWPFIEAK KILDSLNGKV PEKGYVLFET GYGPSGLPHI    50
    GTFAENARVV MVQKAFEQLS DIPTKLICFS DDMDGLRKVP SNIPNPEMVA 100
    QYMDMPLTSI PDPFGECKSY GHYMNAKLCT FLDKFGFQYE FYSSTNCYKA 150
    GLFDDMLIRV LEKYDEIMAL MLPTFREERK TTYAPFMPIC PKTGKVLQVP 200
    IEKWDARAGT VSYKDEDGND VEVPVTGGHC KLQWKPDFGM RWAALNVDYE 250
    MYGKDHLANS RLYSKICQIL GGKPPVQFCY ELFLDENGEK ISKSRGNSIS 300
    VDDWLKYASV ESIALFMYKN PARAKRLFFD VIPKNVDEYI TLNQKYHLEE 350
    DMVTRFANPV YHIHHGNVPK IETFGLTYSL LLNLTAVCNP SDKSVLWGFI 400
    TKYEPKATPN TSTYLDHLAE FAIRYYHDFV QIHKSYLVVS EKHKIILYDI 450
    LDMLSNITDQ TEEENIQKAM YDIGMKAGYK NLRYYFKDLY QILLGQNEGP 500
    RFGTFIKLYG VEATKKLVEE KLYPVA 526
    Length:526
    Mass (Da):60,516
    Last modified:October 11, 2004 - v1
    Checksum:i2A14E4023967A19F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03838.1.
    RefSeqiYP_067320.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03838; AAU03838; RT0359.
    GeneIDi2958659.
    KEGGirty:RT0359.
    PATRICi17909922. VBIRicTyp34752_0375.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03838.1 .
    RefSeqi YP_067320.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68X04.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0359.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03838 ; AAU03838 ; RT0359 .
    GeneIDi 2958659.
    KEGGi rty:RT0359.
    PATRICi 17909922. VBIRicTyp34752_0375.

    Phylogenomic databases

    eggNOGi COG1384.
    HOGENOMi HOG000140447.
    KOi K04566.
    OMAi TMVRHAF.
    OrthoDBi EOG6WHNM6.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-376-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00177. Lys_tRNA_synth_class1.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR002904. Lys-tRNA-ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF01921. tRNA-synt_1f. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00467. lysS_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiSYK_RICTY
    AccessioniPrimary (citable) accession number: Q68X04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3