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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei293ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRTYP257363:G1G0L-365-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
Alternative name(s):
Lysyl-tRNA synthetaseUniRule annotation
Short name:
LysRSUniRule annotation
Gene namesi
Name:lysSUniRule annotation
Ordered Locus Names:RT0359
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000000604 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002780761 – 526Lysine--tRNA ligaseAdd BLAST526

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0359

Structurei

3D structure databases

ProteinModelPortaliQ68X04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi44 – 52"HIGH" region9
Motifi290 – 294"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DK7 Bacteria
COG1384 LUCA
HOGENOMiHOG000140447
KOiK04566
OMAiDWPMRWA
OrthoDBiPOG091H0FHT

Family and domain databases

Gene3Di1.10.10.350, 1 hit
2.30.30.300, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00177 Lys_tRNA_synth_class1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR002904 Lys-tRNA-ligase
IPR023386 Lys-tRNA-ligase_insertion_sf
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR37940 PTHR37940, 1 hit
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00467 lysS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q68X04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVIWKDAIR SNAWPFIEAK KILDSLNGKV PEKGYVLFET GYGPSGLPHI
60 70 80 90 100
GTFAENARVV MVQKAFEQLS DIPTKLICFS DDMDGLRKVP SNIPNPEMVA
110 120 130 140 150
QYMDMPLTSI PDPFGECKSY GHYMNAKLCT FLDKFGFQYE FYSSTNCYKA
160 170 180 190 200
GLFDDMLIRV LEKYDEIMAL MLPTFREERK TTYAPFMPIC PKTGKVLQVP
210 220 230 240 250
IEKWDARAGT VSYKDEDGND VEVPVTGGHC KLQWKPDFGM RWAALNVDYE
260 270 280 290 300
MYGKDHLANS RLYSKICQIL GGKPPVQFCY ELFLDENGEK ISKSRGNSIS
310 320 330 340 350
VDDWLKYASV ESIALFMYKN PARAKRLFFD VIPKNVDEYI TLNQKYHLEE
360 370 380 390 400
DMVTRFANPV YHIHHGNVPK IETFGLTYSL LLNLTAVCNP SDKSVLWGFI
410 420 430 440 450
TKYEPKATPN TSTYLDHLAE FAIRYYHDFV QIHKSYLVVS EKHKIILYDI
460 470 480 490 500
LDMLSNITDQ TEEENIQKAM YDIGMKAGYK NLRYYFKDLY QILLGQNEGP
510 520
RFGTFIKLYG VEATKKLVEE KLYPVA
Length:526
Mass (Da):60,516
Last modified:October 11, 2004 - v1
Checksum:i2A14E4023967A19F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA Translation: AAU03838.1
RefSeqiWP_011190822.1, NC_006142.1

Genome annotation databases

EnsemblBacteriaiAAU03838; AAU03838; RT0359
KEGGirty:RT0359

Similar proteinsi

Entry informationi

Entry nameiSYK_RICTY
AccessioniPrimary (citable) accession number: Q68X04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health