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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei293 – 2931ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-376-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
Alternative name(s):
Lysyl-tRNA synthetaseUniRule annotation
Short name:
LysRSUniRule annotation
Gene namesi
Name:lysSUniRule annotation
Ordered Locus Names:RT0359
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Lysine--tRNA ligasePRO_0000278076Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0359.

Structurei

3D structure databases

ProteinModelPortaliQ68X04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi44 – 529"HIGH" region
Motifi290 – 2945"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1384.
HOGENOMiHOG000140447.
KOiK04566.
OMAiTMVRHAF.
OrthoDBiEOG6WHNM6.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00177. Lys_tRNA_synth_class1.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR002904. Lys-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01921. tRNA-synt_1f. 1 hit.
[Graphical view]
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00467. lysS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68X04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVIWKDAIR SNAWPFIEAK KILDSLNGKV PEKGYVLFET GYGPSGLPHI
60 70 80 90 100
GTFAENARVV MVQKAFEQLS DIPTKLICFS DDMDGLRKVP SNIPNPEMVA
110 120 130 140 150
QYMDMPLTSI PDPFGECKSY GHYMNAKLCT FLDKFGFQYE FYSSTNCYKA
160 170 180 190 200
GLFDDMLIRV LEKYDEIMAL MLPTFREERK TTYAPFMPIC PKTGKVLQVP
210 220 230 240 250
IEKWDARAGT VSYKDEDGND VEVPVTGGHC KLQWKPDFGM RWAALNVDYE
260 270 280 290 300
MYGKDHLANS RLYSKICQIL GGKPPVQFCY ELFLDENGEK ISKSRGNSIS
310 320 330 340 350
VDDWLKYASV ESIALFMYKN PARAKRLFFD VIPKNVDEYI TLNQKYHLEE
360 370 380 390 400
DMVTRFANPV YHIHHGNVPK IETFGLTYSL LLNLTAVCNP SDKSVLWGFI
410 420 430 440 450
TKYEPKATPN TSTYLDHLAE FAIRYYHDFV QIHKSYLVVS EKHKIILYDI
460 470 480 490 500
LDMLSNITDQ TEEENIQKAM YDIGMKAGYK NLRYYFKDLY QILLGQNEGP
510 520
RFGTFIKLYG VEATKKLVEE KLYPVA
Length:526
Mass (Da):60,516
Last modified:October 11, 2004 - v1
Checksum:i2A14E4023967A19F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03838.1.
RefSeqiWP_011190822.1. NC_006142.1.
YP_067320.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03838; AAU03838; RT0359.
KEGGirty:RT0359.
PATRICi17909922. VBIRicTyp34752_0375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03838.1.
RefSeqiWP_011190822.1. NC_006142.1.
YP_067320.1. NC_006142.1.

3D structure databases

ProteinModelPortaliQ68X04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0359.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU03838; AAU03838; RT0359.
KEGGirty:RT0359.
PATRICi17909922. VBIRicTyp34752_0375.

Phylogenomic databases

eggNOGiCOG1384.
HOGENOMiHOG000140447.
KOiK04566.
OMAiTMVRHAF.
OrthoDBiEOG6WHNM6.

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-376-MONOMER.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00177. Lys_tRNA_synth_class1.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR002904. Lys-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01921. tRNA-synt_1f. 1 hit.
[Graphical view]
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00467. lysS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiSYK_RICTY
AccessioniPrimary (citable) accession number: Q68X04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 11, 2004
Last modified: May 27, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.