Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q68WZ8

- MDH_RICTY

UniProt

Q68WZ8 - MDH_RICTY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Malate dehydrogenase

Gene

mdh

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351NADUniRule annotation
Binding sitei84 – 841SubstrateUniRule annotation
Binding sitei90 – 901SubstrateUniRule annotation
Binding sitei97 – 971NADUniRule annotation
Binding sitei122 – 1221SubstrateUniRule annotation
Binding sitei153 – 1531SubstrateUniRule annotation
Active sitei177 – 1771Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NADUniRule annotation
Nucleotide bindingi120 – 1223NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-383-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:RT0365
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Malate dehydrogenasePRO_0000113470Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0365.

Structurei

3D structure databases

ProteinModelPortaliQ68WZ8.
SMRiQ68WZ8. Positions 1-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiLDLMEAQ.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68WZ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKNPKISLI GSGNIGGTLA HLISLKKLGD IVLFDVAEGV PQGKALDIMQ
60 70 80 90 100
AATIAGADIK IKGTNNYKDI EGSDAVIITA GLPRKPGMSR DDLISVNTKI
110 120 130 140 150
MQDVAQNIKK YARNAFVIVI TNPLDIMVYV MLKESGLPHN KVIGMAGVLD
160 170 180 190 200
SSRFNLFLAE EFKVSVRNVN SIVLGGHGDA MVPLVRYSTI SGVPIPDLIK
210 220 230 240 250
MGLSSNKNIE KIIDRTRNGG GEIVALLKTG SAYYAPAASA IAMLESYLKD
260 270 280 290 300
KRQILTCAAY LQGEYDVHDL YIGVPIIIGK EGVIKVIELQ LTEEEKILFD
310
KSVVGVKKLI DAIQ
Length:314
Mass (Da):33,833
Last modified:October 11, 2004 - v1
Checksum:iD7E1637D69E04B0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03844.1.
RefSeqiYP_067326.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03844; AAU03844; RT0365.
GeneIDi2958660.
KEGGirty:RT0365.
PATRICi17909934. VBIRicTyp34752_0381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03844.1 .
RefSeqi YP_067326.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68WZ8.
SMRi Q68WZ8. Positions 1-314.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0365.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03844 ; AAU03844 ; RT0365 .
GeneIDi 2958660.
KEGGi rty:RT0365.
PATRICi 17909934. VBIRicTyp34752_0381.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi LDLMEAQ.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-383-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiMDH_RICTY
AccessioniPrimary (citable) accession number: Q68WZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3