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Q68WZ5

- KDSB_RICTY

UniProt

Q68WZ5 - KDSB_RICTY

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Protein

3-deoxy-manno-octulosonate cytidylyltransferase

Gene

kdsB

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.UniRule annotation

Catalytic activityi

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 3-deoxy-manno-octulosonate cytidylyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-UniPathway
  2. keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-386-MONOMER.
UniPathwayiUPA00030.
UPA00358; UER00476.

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferaseUniRule annotation (EC:2.7.7.38UniRule annotation)
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthaseUniRule annotation
Short name:
CKSUniRule annotation
Short name:
CMP-KDO synthaseUniRule annotation
Gene namesi
Name:kdsBUniRule annotation
Ordered Locus Names:RT0368
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2412413-deoxy-manno-octulosonate cytidylyltransferasePRO_0000274835Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0368.

Structurei

3D structure databases

ProteinModelPortaliQ68WZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1212.
HOGENOMiHOG000007602.
KOiK00979.
OMAiPIPHRRA.
OrthoDBiEOG6KT2SK.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00057. CMP_KDO_synth.
InterProiIPR003329. Cytidylyl_trans.
IPR004528. KdsB.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR21485:SF4. PTHR21485:SF4. 1 hit.
PfamiPF02348. CTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR00466. kdsB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68WZ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNQNVAIII PSRLNSTRLI QKPLQLIGSI TLIERVFKQV NKANIQHTYV
60 70 80 90 100
ATDSEEIANI IKKIGGKVIL TDSDIPTGTD RTYEAFKLIP NNNNIHYIIN
110 120 130 140 150
VQGDIPFIEH RSILKIIEYL KNSEYDIVTP VVRVDRESIE ASSNVTVAVD
160 170 180 190 200
YMGKALYFSR SLIPHGAEEL LYHLGIYGFR KNALEKFVSL KQTFLEKTER
210 220 230 240
LEQLRILENG MTIGTCLVED VPISVDTEED LKKAIKFCRE N
Length:241
Mass (Da):27,435
Last modified:October 11, 2004 - v1
Checksum:iD978CC820BFDA4A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03847.1.
RefSeqiYP_067329.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03847; AAU03847; RT0368.
GeneIDi2958720.
KEGGirty:RT0368.
PATRICi17909940. VBIRicTyp34752_0384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03847.1 .
RefSeqi YP_067329.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68WZ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0368.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03847 ; AAU03847 ; RT0368 .
GeneIDi 2958720.
KEGGi rty:RT0368.
PATRICi 17909940. VBIRicTyp34752_0384.

Phylogenomic databases

eggNOGi COG1212.
HOGENOMi HOG000007602.
KOi K00979.
OMAi PIPHRRA.
OrthoDBi EOG6KT2SK.

Enzyme and pathway databases

UniPathwayi UPA00030 .
UPA00358 ; UER00476 .
BioCyci RTYP257363:GJEQ-386-MONOMER.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
HAMAPi MF_00057. CMP_KDO_synth.
InterProi IPR003329. Cytidylyl_trans.
IPR004528. KdsB.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
PANTHERi PTHR21485:SF4. PTHR21485:SF4. 1 hit.
Pfami PF02348. CTP_transf_3. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR00466. kdsB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiKDSB_RICTY
AccessioniPrimary (citable) accession number: Q68WZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3