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Q68WZ5

- KDSB_RICTY

UniProt

Q68WZ5 - KDSB_RICTY

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Protein
3-deoxy-manno-octulosonate cytidylyltransferase
Gene
kdsB, RT0368
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria By similarity.UniRule annotation

Catalytic activityi

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 3-deoxy-manno-octulosonate cytidylyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-UniPathway
  2. keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-386-MONOMER.
UniPathwayiUPA00030.
UPA00358; UER00476.

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferase (EC:2.7.7.38)
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthase
Short name:
CKS
Short name:
CMP-KDO synthase
Gene namesi
Name:kdsB
Ordered Locus Names:RT0368
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2412413-deoxy-manno-octulosonate cytidylyltransferaseUniRule annotation
PRO_0000274835Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0368.

Structurei

3D structure databases

ProteinModelPortaliQ68WZ5.

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsB family.

Phylogenomic databases

eggNOGiCOG1212.
HOGENOMiHOG000007602.
KOiK00979.
OMAiPIPHRRA.
OrthoDBiEOG6KT2SK.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00057. CMP_KDO_synth.
InterProiIPR003329. Cytidylyl_trans.
IPR004528. KdsB.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR21485:SF4. PTHR21485:SF4. 1 hit.
PfamiPF02348. CTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR00466. kdsB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68WZ5-1 [UniParc]FASTAAdd to Basket

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MKNQNVAIII PSRLNSTRLI QKPLQLIGSI TLIERVFKQV NKANIQHTYV    50
ATDSEEIANI IKKIGGKVIL TDSDIPTGTD RTYEAFKLIP NNNNIHYIIN 100
VQGDIPFIEH RSILKIIEYL KNSEYDIVTP VVRVDRESIE ASSNVTVAVD 150
YMGKALYFSR SLIPHGAEEL LYHLGIYGFR KNALEKFVSL KQTFLEKTER 200
LEQLRILENG MTIGTCLVED VPISVDTEED LKKAIKFCRE N 241
Length:241
Mass (Da):27,435
Last modified:October 11, 2004 - v1
Checksum:iD978CC820BFDA4A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03847.1.
RefSeqiYP_067329.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03847; AAU03847; RT0368.
GeneIDi2958720.
KEGGirty:RT0368.
PATRICi17909940. VBIRicTyp34752_0384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03847.1 .
RefSeqi YP_067329.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68WZ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0368.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03847 ; AAU03847 ; RT0368 .
GeneIDi 2958720.
KEGGi rty:RT0368.
PATRICi 17909940. VBIRicTyp34752_0384.

Phylogenomic databases

eggNOGi COG1212.
HOGENOMi HOG000007602.
KOi K00979.
OMAi PIPHRRA.
OrthoDBi EOG6KT2SK.

Enzyme and pathway databases

UniPathwayi UPA00030 .
UPA00358 ; UER00476 .
BioCyci RTYP257363:GJEQ-386-MONOMER.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
HAMAPi MF_00057. CMP_KDO_synth.
InterProi IPR003329. Cytidylyl_trans.
IPR004528. KdsB.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
PANTHERi PTHR21485:SF4. PTHR21485:SF4. 1 hit.
Pfami PF02348. CTP_transf_3. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR00466. kdsB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiKDSB_RICTY
AccessioniPrimary (citable) accession number: Q68WZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi