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Q68WZ5

- KDSB_RICTY

UniProt

Q68WZ5 - KDSB_RICTY

Protein

3-deoxy-manno-octulosonate cytidylyltransferase

Gene

kdsB

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.UniRule annotation

    Catalytic activityi

    CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 3-deoxy-manno-octulosonate cytidylyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-UniPathway
    2. keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-386-MONOMER.
    UniPathwayiUPA00030.
    UPA00358; UER00476.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-deoxy-manno-octulosonate cytidylyltransferaseUniRule annotation (EC:2.7.7.38UniRule annotation)
    Alternative name(s):
    CMP-2-keto-3-deoxyoctulosonic acid synthaseUniRule annotation
    Short name:
    CKSUniRule annotation
    Short name:
    CMP-KDO synthaseUniRule annotation
    Gene namesi
    Name:kdsBUniRule annotation
    Ordered Locus Names:RT0368
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2412413-deoxy-manno-octulosonate cytidylyltransferasePRO_0000274835Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi257363.RT0368.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68WZ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the KdsB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1212.
    HOGENOMiHOG000007602.
    KOiK00979.
    OMAiPIPHRRA.
    OrthoDBiEOG6KT2SK.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    HAMAPiMF_00057. CMP_KDO_synth.
    InterProiIPR003329. Cytidylyl_trans.
    IPR004528. KdsB.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PANTHERiPTHR21485:SF4. PTHR21485:SF4. 1 hit.
    PfamiPF02348. CTP_transf_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR00466. kdsB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q68WZ5-1 [UniParc]FASTAAdd to Basket

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    MKNQNVAIII PSRLNSTRLI QKPLQLIGSI TLIERVFKQV NKANIQHTYV    50
    ATDSEEIANI IKKIGGKVIL TDSDIPTGTD RTYEAFKLIP NNNNIHYIIN 100
    VQGDIPFIEH RSILKIIEYL KNSEYDIVTP VVRVDRESIE ASSNVTVAVD 150
    YMGKALYFSR SLIPHGAEEL LYHLGIYGFR KNALEKFVSL KQTFLEKTER 200
    LEQLRILENG MTIGTCLVED VPISVDTEED LKKAIKFCRE N 241
    Length:241
    Mass (Da):27,435
    Last modified:October 11, 2004 - v1
    Checksum:iD978CC820BFDA4A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03847.1.
    RefSeqiYP_067329.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03847; AAU03847; RT0368.
    GeneIDi2958720.
    KEGGirty:RT0368.
    PATRICi17909940. VBIRicTyp34752_0384.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03847.1 .
    RefSeqi YP_067329.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68WZ5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0368.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03847 ; AAU03847 ; RT0368 .
    GeneIDi 2958720.
    KEGGi rty:RT0368.
    PATRICi 17909940. VBIRicTyp34752_0384.

    Phylogenomic databases

    eggNOGi COG1212.
    HOGENOMi HOG000007602.
    KOi K00979.
    OMAi PIPHRRA.
    OrthoDBi EOG6KT2SK.

    Enzyme and pathway databases

    UniPathwayi UPA00030 .
    UPA00358 ; UER00476 .
    BioCyci RTYP257363:GJEQ-386-MONOMER.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    HAMAPi MF_00057. CMP_KDO_synth.
    InterProi IPR003329. Cytidylyl_trans.
    IPR004528. KdsB.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    PANTHERi PTHR21485:SF4. PTHR21485:SF4. 1 hit.
    Pfami PF02348. CTP_transf_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR00466. kdsB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiKDSB_RICTY
    AccessioniPrimary (citable) accession number: Q68WZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3