Q68WZ5 (KDSB_RICTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferase
EC=2.7.7.38

Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthase
Short name=CKS
Short name=CMP-KDO synthase

Gene names

Name:	kdsB
Ordered Locus Names:	RT0368

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia typhi

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria By similarity. HAMAP-Rule MF_00057
Catalytic activity	CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. HAMAP-Rule MF_00057
Pathway	Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1. HAMAP-Rule MF_00057 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP-Rule MF_00057
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00057.
Sequence similarities	Belongs to the KdsB family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	3-deoxy-manno-octulosonate cytidylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	3-deoxy-manno-octulosonate cytidylyltransferase HAMAP-Rule MF_00057		PRO_0000274835

Sequences

	Sequence		Length	Mass (Da)
	Q68WZ5 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: D978CC820BFDA4A5	FASTA	241	27,435
	10 20 30 40 50 60 MKNQNVAIII PSRLNSTRLI QKPLQLIGSI TLIERVFKQV NKANIQHTYV ATDSEEIANI 70 80 90 100 110 120 IKKIGGKVIL TDSDIPTGTD RTYEAFKLIP NNNNIHYIIN VQGDIPFIEH RSILKIIEYL 130 140 150 160 170 180 KNSEYDIVTP VVRVDRESIE ASSNVTVAVD YMGKALYFSR SLIPHGAEEL LYHLGIYGFR 190 200 210 220 230 240 KNALEKFVSL KQTFLEKTER LEQLRILENG MTIGTCLVED VPISVDTEED LKKAIKFCRE N

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU03847.1.
RefSeq	YP_067329.1. NC_006142.1.
3D structure databases
HSSP	HSSP built from PDB template 1VIC based on UniProtKB P44490.
ProteinModelPortal	Q68WZ5.
ModBase	Search...
Protein-protein interaction databases
STRING	257363.RT0368.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAU03847; AAU03847; RT0368.
GeneID	2958720.
KEGG	rty:RT0368.
PATRIC	17909940. VBIRicTyp34752_0384.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1212.
HOGENOM	HOG000007602.
KO	K00979.
OMA	NSGTERC.
ProtClustDB	PRK05450.
Enzyme and pathway databases
BioCyc	RTYP257363:GJEQ-386-MONOMER.
UniPathway	UPA00030. UPA00358; UER00476.
Family and domain databases
HAMAP	MF_00057. CMP-KDO_synth.
InterPro	IPR003329. Cytidylyl_trans. IPR004528. KdsB. [Graphical view]
PANTHER	PTHR21485:SF4. PTHR21485:SF4. 1 hit.
Pfam	PF02348. CTP_transf_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR00466. kdsB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSB_RICTY

Accession

Primary (citable) accession number: Q68WZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program