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Q68WZ5 (KDSB_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-deoxy-manno-octulosonate cytidylyltransferase

EC=2.7.7.38
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthase
Short name=CKS
Short name=CMP-KDO synthase
Gene names
Name:kdsB
Ordered Locus Names:RT0368
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria By similarity. HAMAP-Rule MF_00057

Catalytic activity

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. HAMAP-Rule MF_00057

Pathway

Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1. HAMAP-Rule MF_00057

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP-Rule MF_00057

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00057.

Sequence similarities

Belongs to the KdsB family.

Ontologies

Keywords
   Biological processLipopolysaccharide biosynthesis
   Cellular componentCytoplasm
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processCMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

keto-3-deoxy-D-manno-octulosonic acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-deoxy-manno-octulosonate cytidylyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2412413-deoxy-manno-octulosonate cytidylyltransferase HAMAP-Rule MF_00057
PRO_0000274835

Sequences

Sequence LengthMass (Da)Tools
Q68WZ5 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: D978CC820BFDA4A5

FASTA24127,435
        10         20         30         40         50         60 
MKNQNVAIII PSRLNSTRLI QKPLQLIGSI TLIERVFKQV NKANIQHTYV ATDSEEIANI 

        70         80         90        100        110        120 
IKKIGGKVIL TDSDIPTGTD RTYEAFKLIP NNNNIHYIIN VQGDIPFIEH RSILKIIEYL 

       130        140        150        160        170        180 
KNSEYDIVTP VVRVDRESIE ASSNVTVAVD YMGKALYFSR SLIPHGAEEL LYHLGIYGFR 

       190        200        210        220        230        240 
KNALEKFVSL KQTFLEKTER LEQLRILENG MTIGTCLVED VPISVDTEED LKKAIKFCRE 


N 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU03847.1.
RefSeqYP_067329.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68WZ5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0368.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU03847; AAU03847; RT0368.
GeneID2958720.
KEGGrty:RT0368.
PATRIC17909940. VBIRicTyp34752_0384.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1212.
HOGENOMHOG000007602.
KOK00979.
OMAPIPHRRA.
OrthoDBEOG6KT2SK.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-386-MONOMER.
UniPathwayUPA00030.
UPA00358; UER00476.

Family and domain databases

Gene3D3.90.550.10. 1 hit.
HAMAPMF_00057. CMP_KDO_synth.
InterProIPR003329. Cytidylyl_trans.
IPR004528. KdsB.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERPTHR21485:SF4. PTHR21485:SF4. 1 hit.
PfamPF02348. CTP_transf_3. 1 hit.
[Graphical view]
SUPFAMSSF53448. SSF53448. 1 hit.
TIGRFAMsTIGR00466. kdsB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKDSB_RICTY
AccessionPrimary (citable) accession number: Q68WZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways