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Q68WW9

- MURD_RICTY

UniProt

Q68WW9 - MURD_RICTY

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Protein
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Gene
murD, RT0396
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity.UniRule annotation

Catalytic activityi

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi111 – 1177ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. UDP-N-acetylmuramoylalanine-D-glutamate ligase activity Source: UniProtKB-HAMAP
  3. tetrahydrofolylpolyglutamate synthase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  4. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-418-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC:6.3.2.9)
Alternative name(s):
D-glutamic acid-adding enzyme
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Gene namesi
Name:murD
Ordered Locus Names:RT0396
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457UDP-N-acetylmuramoylalanine--D-glutamate ligaseUniRule annotation
PRO_0000109074Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0396.

Structurei

3D structure databases

ProteinModelPortaliQ68WW9.

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.

Phylogenomic databases

eggNOGiCOG0771.
HOGENOMiHOG000049428.
KOiK01925.
OMAiFVCYPSK.
OrthoDBiEOG6PKFCR.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00639. MurD.
InterProiIPR018109. Folylpolyglutamate_synth_CS.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
PfamiPF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01087. murD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68WW9-1 [UniParc]FASTAAdd to Basket

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MNAYTKQKIG IFGLGKTGIS VYEELKNKYD LIVYDDLKAK RDIFEKLFGN    50
KLITILSDSR WQDLDKIVLS PGVPLTHEVV RIAHHFNIPI ISDIDLLFEK 100
SKNLKFIAIT GTNGKSTTAA LISHILNSNG LDYTVAGNIG VPALQAKASK 150
DGYVLELSSF QLDLVKIFTV KVAVLLNITP DHLDRYQDMN GYIAAKAKIF 200
DRMDKDSYAV INIDNDYCRK IFLLLQREQL IKLIPFSVTK ILNNGISIVD 250
DKIHDNNLTY KLPLNKNLQG LHNCENIAAS YAVSKIIGVE SKKILESISS 300
FQSLHHRMQY IGSINNISFY NDSKATNAIS ALQSIKALDN IYWLAGGIPK 350
EGGIEGIKPY FNKIKKAYFY GQAKTMFANT AKNIIDCVIC DNLEYAFNIA 400
YKDAVSDNTE IKNILLAPSC SSYDQFKNFE ERGELFIKLS KNVIGSNYLL 450
SNLRIFD 457
Length:457
Mass (Da):51,346
Last modified:October 11, 2004 - v1
Checksum:i3EDA3153E473EF65
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03873.1.
RefSeqiYP_067355.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03873; AAU03873; RT0396.
GeneIDi2959266.
KEGGirty:RT0396.
PATRICi17910024. VBIRicTyp34752_0424.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03873.1 .
RefSeqi YP_067355.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68WW9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 257363.RT0396.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03873 ; AAU03873 ; RT0396 .
GeneIDi 2959266.
KEGGi rty:RT0396.
PATRICi 17910024. VBIRicTyp34752_0424.

Phylogenomic databases

eggNOGi COG0771.
HOGENOMi HOG000049428.
KOi K01925.
OMAi FVCYPSK.
OrthoDBi EOG6PKFCR.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci RTYP257363:GJEQ-418-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPi MF_00639. MurD.
InterProi IPR018109. Folylpolyglutamate_synth_CS.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view ]
Pfami PF08245. Mur_ligase_M. 1 hit.
[Graphical view ]
SUPFAMi SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsi TIGR01087. murD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiMURD_RICTY
AccessioniPrimary (citable) accession number: Q68WW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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