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Q68WW9 (MURD_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase

EC=6.3.2.9
Alternative name(s):
D-glutamic acid-adding enzyme
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Gene names
Name:murD
Ordered Locus Names:RT0396
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity. HAMAP-Rule MF_00639

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. HAMAP-Rule MF_00639

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00639

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00639.

Sequence similarities

Belongs to the MurCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457UDP-N-acetylmuramoylalanine--D-glutamate ligase HAMAP-Rule MF_00639
PRO_0000109074

Regions

Nucleotide binding111 – 1177ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q68WW9 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 3EDA3153E473EF65

FASTA45751,346
        10         20         30         40         50         60 
MNAYTKQKIG IFGLGKTGIS VYEELKNKYD LIVYDDLKAK RDIFEKLFGN KLITILSDSR 

        70         80         90        100        110        120 
WQDLDKIVLS PGVPLTHEVV RIAHHFNIPI ISDIDLLFEK SKNLKFIAIT GTNGKSTTAA 

       130        140        150        160        170        180 
LISHILNSNG LDYTVAGNIG VPALQAKASK DGYVLELSSF QLDLVKIFTV KVAVLLNITP 

       190        200        210        220        230        240 
DHLDRYQDMN GYIAAKAKIF DRMDKDSYAV INIDNDYCRK IFLLLQREQL IKLIPFSVTK 

       250        260        270        280        290        300 
ILNNGISIVD DKIHDNNLTY KLPLNKNLQG LHNCENIAAS YAVSKIIGVE SKKILESISS 

       310        320        330        340        350        360 
FQSLHHRMQY IGSINNISFY NDSKATNAIS ALQSIKALDN IYWLAGGIPK EGGIEGIKPY 

       370        380        390        400        410        420 
FNKIKKAYFY GQAKTMFANT AKNIIDCVIC DNLEYAFNIA YKDAVSDNTE IKNILLAPSC 

       430        440        450 
SSYDQFKNFE ERGELFIKLS KNVIGSNYLL SNLRIFD 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU03873.1.
RefSeqYP_067355.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68WW9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0396.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU03873; AAU03873; RT0396.
GeneID2959266.
KEGGrty:RT0396.
PATRIC17910024. VBIRicTyp34752_0424.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0771.
HOGENOMHOG000049428.
KOK01925.
OMAAPFAGNI.
OrthoDBEOG6PKFCR.
ProtClustDBPRK01368.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-418-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPMF_00639. MurD.
InterProIPR018109. Folylpolyglutamate_synth_CS.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
PANTHERPTHR23135:SF2. PTHR23135:SF2. 1 hit.
PfamPF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsTIGR01087. murD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURD_RICTY
AccessionPrimary (citable) accession number: Q68WW9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways