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Q68WW9

- MURD_RICTY

UniProt

Q68WW9 - MURD_RICTY

Protein

UDP-N-acetylmuramoylalanine--D-glutamate ligase

Gene

murD

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).UniRule annotation

    Catalytic activityi

    ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi111 – 1177ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tetrahydrofolylpolyglutamate synthase activity Source: InterPro
    3. UDP-N-acetylmuramoylalanine-D-glutamate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-418-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylmuramoylalanine--D-glutamate ligaseUniRule annotation (EC:6.3.2.9UniRule annotation)
    Alternative name(s):
    D-glutamic acid-adding enzymeUniRule annotation
    UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUniRule annotation
    Gene namesi
    Name:murDUniRule annotation
    Ordered Locus Names:RT0396
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 457457UDP-N-acetylmuramoylalanine--D-glutamate ligasePRO_0000109074Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi257363.RT0396.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68WW9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MurCDEF family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0771.
    HOGENOMiHOG000049428.
    KOiK01925.
    OMAiFVCYPSK.
    OrthoDBiEOG6PKFCR.

    Family and domain databases

    Gene3Di3.40.1190.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPiMF_00639. MurD.
    InterProiIPR018109. Folylpolyglutamate_synth_CS.
    IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR016040. NAD(P)-bd_dom.
    IPR005762. UDP-N-AcMur-Glu_ligase.
    [Graphical view]
    PfamiPF08245. Mur_ligase_M. 1 hit.
    [Graphical view]
    SUPFAMiSSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsiTIGR01087. murD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q68WW9-1 [UniParc]FASTAAdd to Basket

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    MNAYTKQKIG IFGLGKTGIS VYEELKNKYD LIVYDDLKAK RDIFEKLFGN    50
    KLITILSDSR WQDLDKIVLS PGVPLTHEVV RIAHHFNIPI ISDIDLLFEK 100
    SKNLKFIAIT GTNGKSTTAA LISHILNSNG LDYTVAGNIG VPALQAKASK 150
    DGYVLELSSF QLDLVKIFTV KVAVLLNITP DHLDRYQDMN GYIAAKAKIF 200
    DRMDKDSYAV INIDNDYCRK IFLLLQREQL IKLIPFSVTK ILNNGISIVD 250
    DKIHDNNLTY KLPLNKNLQG LHNCENIAAS YAVSKIIGVE SKKILESISS 300
    FQSLHHRMQY IGSINNISFY NDSKATNAIS ALQSIKALDN IYWLAGGIPK 350
    EGGIEGIKPY FNKIKKAYFY GQAKTMFANT AKNIIDCVIC DNLEYAFNIA 400
    YKDAVSDNTE IKNILLAPSC SSYDQFKNFE ERGELFIKLS KNVIGSNYLL 450
    SNLRIFD 457
    Length:457
    Mass (Da):51,346
    Last modified:October 11, 2004 - v1
    Checksum:i3EDA3153E473EF65
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03873.1.
    RefSeqiYP_067355.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03873; AAU03873; RT0396.
    GeneIDi2959266.
    KEGGirty:RT0396.
    PATRICi17910024. VBIRicTyp34752_0424.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03873.1 .
    RefSeqi YP_067355.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68WW9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0396.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03873 ; AAU03873 ; RT0396 .
    GeneIDi 2959266.
    KEGGi rty:RT0396.
    PATRICi 17910024. VBIRicTyp34752_0424.

    Phylogenomic databases

    eggNOGi COG0771.
    HOGENOMi HOG000049428.
    KOi K01925.
    OMAi FVCYPSK.
    OrthoDBi EOG6PKFCR.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci RTYP257363:GJEQ-418-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPi MF_00639. MurD.
    InterProi IPR018109. Folylpolyglutamate_synth_CS.
    IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR016040. NAD(P)-bd_dom.
    IPR005762. UDP-N-AcMur-Glu_ligase.
    [Graphical view ]
    Pfami PF08245. Mur_ligase_M. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsi TIGR01087. murD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiMURD_RICTY
    AccessioniPrimary (citable) accession number: Q68WW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3