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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei598ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRTYP257363:G1G0L-415-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:RT0407
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000000604 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520761 – 828Leucine--tRNA ligaseAdd BLAST828

Proteomic databases

PRIDEiQ68WV8

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0407

Structurei

3D structure databases

ProteinModelPortaliQ68WV8
SMRiQ68WV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 46"HIGH" regionAdd BLAST11
Motifi595 – 599"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q68WV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKIEQKWQK IWKEEKAFQV SNDSSKPKYY VLEMLPYPSG KIHIGHIRNY
60 70 80 90 100
SIGDVIARFM TMQGFNVLHP MGWDAFGLPA ENAAIQNNSR PQDWTYSNIE
110 120 130 140 150
YMKKQLQSMG FSYDWTREIN SCDPQYYKHE QKFFLELYDR DLVYQKESLV
160 170 180 190 200
NWDPVDNTVL ANEQVVNGRG WRSGAIIEKR YLNQWFLKIT NYAEELLNEI
210 220 230 240 250
QNLKDWPEAV RVMQEEWIGK STGVNFHFKI KYHENSTIEV FSTKPETIFG
260 270 280 290 300
ASFIGIAFNH PIIEQLIFKT DEIANFITKC SYITKSSELE KSEKEGVFTG
310 320 330 340 350
LYVIHPFDAN IILPVIITNF VLMDYGTGAI FGCPAHDKRD HELAMKMNLP
360 370 380 390 400
IKKVIGTDNT QEEVLINSDW LNGLTSSEAK QKVISKFETL GIGKRSVNYR
410 420 430 440 450
LKDWGISRQR FWGCPIPIIY CETCGIVPVP YKDLPVTLPD DVSFDNNYNP
460 470 480 490 500
LEHHPSWKHV NCPKCDNHAI RETDTFDTFF ESSWYFTRYC NNNAVEMTDS
510 520 530 540 550
KACNYWLPVD KYIGGIEHAV MHLLYARFFT KLMNEHHYVS IREPFKGLFT
560 570 580 590 600
QGMVLHATYK DENNNWLYPA EVVKNGNEFF HKETNTRVVQ GRIEKMSKSK
610 620 630 640 650
KNIIDLETIQ EQYSADAIRL FVLSDSPPEK DLQWSASGIE GCSRFIHKLD
660 670 680 690 700
NMFEVISSLK DDMNNEINTE LNRLIHFTIK HVADDIKTFS LNRAIARMRT
710 720 730 740 750
LTNAIYCEIS KDKIDVRTIK YGFNVLIQLL NPFIPHITEE IWQKLGNKER
760 770 780 790 800
LYKSVFAEFD DSMLEFSTYI MAVQVNGKLR DTYEFNTDIS EDEVKQITVN
810 820
LPKIQKFLAG KEPNKIILVP RKIVNIII
Length:828
Mass (Da):96,495
Last modified:October 11, 2004 - v1
Checksum:i5981B26469952B26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA Translation: AAU03884.1
RefSeqiWP_011190868.1, NC_006142.1

Genome annotation databases

EnsemblBacteriaiAAU03884; AAU03884; RT0407
KEGGirty:RT0407

Similar proteinsi

Entry informationi

Entry nameiSYL_RICTY
AccessioniPrimary (citable) accession number: Q68WV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health