Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q68WV8

- SYL_RICTY

UniProt

Q68WV8 - SYL_RICTY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei598 – 5981ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-429-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:RT0407
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 828828Leucine--tRNA ligasePRO_0000152076Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0407.

Structurei

3D structure databases

ProteinModelPortaliQ68WV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 4611"HIGH" regionAdd
BLAST
Motifi595 – 5995"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVVHCDAC.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68WV8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHKIEQKWQK IWKEEKAFQV SNDSSKPKYY VLEMLPYPSG KIHIGHIRNY
60 70 80 90 100
SIGDVIARFM TMQGFNVLHP MGWDAFGLPA ENAAIQNNSR PQDWTYSNIE
110 120 130 140 150
YMKKQLQSMG FSYDWTREIN SCDPQYYKHE QKFFLELYDR DLVYQKESLV
160 170 180 190 200
NWDPVDNTVL ANEQVVNGRG WRSGAIIEKR YLNQWFLKIT NYAEELLNEI
210 220 230 240 250
QNLKDWPEAV RVMQEEWIGK STGVNFHFKI KYHENSTIEV FSTKPETIFG
260 270 280 290 300
ASFIGIAFNH PIIEQLIFKT DEIANFITKC SYITKSSELE KSEKEGVFTG
310 320 330 340 350
LYVIHPFDAN IILPVIITNF VLMDYGTGAI FGCPAHDKRD HELAMKMNLP
360 370 380 390 400
IKKVIGTDNT QEEVLINSDW LNGLTSSEAK QKVISKFETL GIGKRSVNYR
410 420 430 440 450
LKDWGISRQR FWGCPIPIIY CETCGIVPVP YKDLPVTLPD DVSFDNNYNP
460 470 480 490 500
LEHHPSWKHV NCPKCDNHAI RETDTFDTFF ESSWYFTRYC NNNAVEMTDS
510 520 530 540 550
KACNYWLPVD KYIGGIEHAV MHLLYARFFT KLMNEHHYVS IREPFKGLFT
560 570 580 590 600
QGMVLHATYK DENNNWLYPA EVVKNGNEFF HKETNTRVVQ GRIEKMSKSK
610 620 630 640 650
KNIIDLETIQ EQYSADAIRL FVLSDSPPEK DLQWSASGIE GCSRFIHKLD
660 670 680 690 700
NMFEVISSLK DDMNNEINTE LNRLIHFTIK HVADDIKTFS LNRAIARMRT
710 720 730 740 750
LTNAIYCEIS KDKIDVRTIK YGFNVLIQLL NPFIPHITEE IWQKLGNKER
760 770 780 790 800
LYKSVFAEFD DSMLEFSTYI MAVQVNGKLR DTYEFNTDIS EDEVKQITVN
810 820
LPKIQKFLAG KEPNKIILVP RKIVNIII
Length:828
Mass (Da):96,495
Last modified:October 11, 2004 - v1
Checksum:i5981B26469952B26
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03884.1.
RefSeqiYP_067366.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03884; AAU03884; RT0407.
GeneIDi2958622.
KEGGirty:RT0407.
PATRICi17910048. VBIRicTyp34752_0436.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03884.1 .
RefSeqi YP_067366.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68WV8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0407.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03884 ; AAU03884 ; RT0407 .
GeneIDi 2958622.
KEGGi rty:RT0407.
PATRICi 17910048. VBIRicTyp34752_0436.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VVHCDAC.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-429-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiSYL_RICTY
AccessioniPrimary (citable) accession number: Q68WV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3