Q68WV5 (CDSA_RICTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidate cytidylyltransferase
EC=2.7.7.41

Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name=CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase

Gene names

Name:	cdsA
Ordered Locus Names:	RT0410

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia typhi

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Phospholipid biosynthesis Phospholipid metabolism
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	CDP-diacylglycerol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 228	228	Phosphatidate cytidylyltransferase		PRO_0000281059
Regions
	Transmembrane	31 – 51	21	Helical; Potential
	Transmembrane	65 – 85	21	Helical; Potential
	Transmembrane	93 – 113	21	Helical; Potential
	Transmembrane	131 – 151	21	Helical; Potential
	Transmembrane	165 – 185	21	Helical; Potential
	Transmembrane	206 – 226	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q68WV5 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 44225A1426C3E856	FASTA	228	25,817
	10 20 30 40 50 60 MITQKEKEHL AKDKQNIYLR IISGIVLVSL FVVAILWFKT LFYILMILVG LGMLSEWCNM 70 80 90 100 110 120 TSSSIHYLLI GFIIIPIPIS LLIFLSTQES NRLVIMLYFC IIWSVDTFAM IGGKTFKGTK 130 140 150 160 170 180 LAPKISPKKT WTGLIIGTIS AGLIAVLVSL IPYYHIENYY FSNKIYLFII SCILALIAQS 190 200 210 220 SDLFISYFKR KFNIKDSGHI IPGHGGVLDR FDSIILTAPV FFGINIYL

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU03887.1.
RefSeq	YP_067369.1. NC_006142.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	257363.RT0410.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAU03887; AAU03887; RT0410.
GeneID	2958598.
KEGG	rty:RT0410.
PATRIC	17910054. VBIRicTyp34752_0439.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0575.
HOGENOM	HOG000006169.
KO	K00981.
OMA	VELFNIM.
ProtClustDB	CLSK870917.
Enzyme and pathway databases
BioCyc	RTYP257363:GJEQ-432-MONOMER.
UniPathway	UPA00557; UER00614.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_RICTY

Accession

Primary (citable) accession number: Q68WV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program