Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q68WV5 (CDSA_RICTY)

Last modified November 3, 2009. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthetase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthetase
    CDP-DAG synthase
Gene names
Name: cdsA
Ordered Locus Names: RT0410
OrganismRickettsia typhi [Complete proteome] [HAMAP]
Taxonomic identifier785 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathway

Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the CDS family.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionphosphatidate cytidylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 228228Phosphatidate cytidylyltransferase
PRO_0000281059

Regions

Transmembrane31 – 5121 Potential
Transmembrane65 – 8521 Potential
Transmembrane93 – 11321 Potential
Transmembrane131 – 15121 Potential
Transmembrane165 – 18521 Potential
Transmembrane206 – 22621 Potential

Sequences

Sequence LengthMass (Da)Tools
Q68WV5-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 44225A1426C3E856

FASTA22825,817
        10         20         30         40         50         60 
MITQKEKEHL AKDKQNIYLR IISGIVLVSL FVVAILWFKT LFYILMILVG LGMLSEWCNM 

        70         80         90        100        110        120 
TSSSIHYLLI GFIIIPIPIS LLIFLSTQES NRLVIMLYFC IIWSVDTFAM IGGKTFKGTK 

       130        140        150        160        170        180 
LAPKISPKKT WTGLIIGTIS AGLIAVLVSL IPYYHIENYY FSNKIYLFII SCILALIAQS 

       190        200        210        220 
SDLFISYFKR KFNIKDSGHI IPGHGGVLDR FDSIILTAPV FFGINIYL 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

AE017197 Genomic DNA. Translation: AAU03887.1.
RefSeqYP_067369.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2958598.
GenomeReviewsGene locus RT0410 in contig AE017197_GR.
KEGGrty:RT0410.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ68WV5.
OMACTIFGSI.

Enzyme and pathway databases

BioCycRTYP257363:RT0410-MON.
BRENDA2.7.7.41. 281221.

Family and domain databases

InterProIPR000374. PC_trans.
[Graphical view]
PfamPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDSA_RICTY
AccessionPrimary (citable) accession number: Q68WV5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2004
Last modified: November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents