Reviewed, UniProtKB/Swiss-Prot Q68WV5 (CDSA_RICTY)

Names and origin

Protein names

Recommended name:
    Phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthetase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthetase
    CDP-DAG synthase

Gene names

Name:	cdsA
Ordered Locus Names:	RT0410

Organism

Rickettsia typhi [Complete proteome] [HAMAP]

Taxonomic identifier

785 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 228	228	Phosphatidate cytidylyltransferase		PRO_0000281059
Regions
	Transmembrane	31 – 51	21	Potential
	Transmembrane	65 – 85	21	Potential
	Transmembrane	93 – 113	21	Potential
	Transmembrane	131 – 151	21	Potential
	Transmembrane	165 – 185	21	Potential
	Transmembrane	206 – 226	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q68WV5-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 44225A1426C3E856	FASTA	228	25,817
	10 20 30 40 50 60 MITQKEKEHL AKDKQNIYLR IISGIVLVSL FVVAILWFKT LFYILMILVG LGMLSEWCNM 70 80 90 100 110 120 TSSSIHYLLI GFIIIPIPIS LLIFLSTQES NRLVIMLYFC IIWSVDTFAM IGGKTFKGTK 130 140 150 160 170 180 LAPKISPKKT WTGLIIGTIS AGLIAVLVSL IPYYHIENYY FSNKIYLFII SCILALIAQS 190 200 210 220 SDLFISYFKR KFNIKDSGHI IPGHGGVLDR FDSIILTAPV FFGINIYL

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017197 Genomic DNA. Translation: AAU03887.1.
RefSeq	YP_067369.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2958598.
GenomeReviews	Gene locus RT0410 in contig AE017197_GR.
KEGG	rty:RT0410.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q68WV5.
OMA	CTIFGSI.
Enzyme and pathway databases
BioCyc	RTYP257363:RT0410-MON.
BRENDA	2.7.7.41. 281221.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_RICTY

Accession

Primary (citable) accession number: Q68WV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	October 11, 2004
Last modified:	November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)