Q68WU5 (SUCC_RICTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Succinyl-CoA ligase [ADP-forming] subunit beta
EC=6.2.1.5

Alternative name(s):
Succinyl-CoA synthetase subunit beta
Short name=SCS-beta

Gene names

Name:	sucC
Ordered Locus Names:	RT0420

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia typhi

Protein attributes

Sequence length	386 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. HAMAP-Rule MF_00558
Cofactor	Binds 1 magnesium or manganese ion per subunit By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. HAMAP-Rule MF_00558
Subunit structure	Heterotetramer of two alpha and two beta subunits By similarity.
Sequence similarities	Belongs to the succinate/malate CoA ligase beta subunit family. Contains 1 ATP-grasp domain.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: HAMAP succinate-CoA ligase (ADP-forming) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 386	386	Succinyl-CoA ligase [ADP-forming] subunit beta HAMAP-Rule MF_00558		PRO_0000102852
Regions
	Domain	9 – 244	236	ATP-grasp
	Nucleotide binding	35 – 108	74	ATP By similarity
Sites
	Metal binding	197	1	Magnesium or manganese By similarity
	Metal binding	199	1	Magnesium or manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q68WU5 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 8FDEB965DDCC45EF	FASTA	386	41,904
	10 20 30 40 50 60 MNIHEYQAKE ILRKYGVPTS TGLVVTKTEK INEAIDKLNT KVYVVKAQIH AGGRGKAGGV 70 80 90 100 110 120 KVVKSKEEAK KVAHDMFGIN LVTHQTGPQG QKVNHLYIES GCDILKEYYF SIVFDRSASC 130 140 150 160 170 180 ITFIASTEGG VDIEAVAEKM PEKIIKFAVD PATGLQDFHM RGIAYGLGFK DSQAKQMKEI 190 200 210 220 230 240 VKSVYNAFIE TDATQIEINP LIINSYKNLL ALDAKITFDD NGLFKHPNIT AMRDHDEEDP 250 260 270 280 290 300 LETRAANAGL SYVKMDGNIG CMVNGAGLAM ATMDIIKLYG ASPANFLDVG GGADRERVKE 310 320 330 340 350 360 ALKIILSDKE VKGILVNIFG GIMRCDIIAE GIIAAARDIG ITVPLVVRLA GTNVEKGKEI 370 380 LSNSNLKIIP AHDLADAANK IVEAIR

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU03897.1.
RefSeq	YP_067379.1. NC_006142.1.
3D structure databases
ProteinModelPortal	Q68WU5.
SMR	Q68WU5. Positions 1-385.
ModBase	Search...
Protein-protein interaction databases
STRING	257363.RT0420.
Proteomic databases
PRIDE	Q68WU5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAU03897; AAU03897; RT0420.
GeneID	2958771.
KEGG	rty:RT0420.
PATRIC	17910072. VBIRicTyp34752_0448.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0045.
HOGENOM	HOG000007059.
KO	K01903.
OMA	QPVTKIL.
ProtClustDB	PRK00696.
Enzyme and pathway databases
BioCyc	RTYP257363:GJEQ-442-MONOMER.
UniPathway	UPA00223; UER00999.
Family and domain databases
Gene3D	3.30.1490.20. 1 hit. 3.30.470.20. 1 hit. 3.40.50.261. 1 hit.
HAMAP	MF_00558. Succ_CoA_beta.
InterPro	IPR011761. ATP-grasp. IPR013650. ATP-grasp_succ-CoA_synth-type. IPR013815. ATP_grasp_subdomain_1. IPR013816. ATP_grasp_subdomain_2. IPR005811. CoA_ligase. IPR017866. Succ-CoA_synthase_bsu_CS. IPR005809. Succ_CoA_synthase_bsu. IPR016102. Succinyl-CoA_synth-like. [Graphical view]
PANTHER	PTHR11815. PTHR11815. 1 hit.
Pfam	PF08442. ATP-grasp_2. 1 hit. PF00549. Ligase_CoA. 1 hit. [Graphical view]
PIRSF	PIRSF001554. SucCS_beta. 1 hit.
SUPFAM	SSF52210. CoA_ligase. 1 hit.
TIGRFAMs	TIGR01016. sucCoAbeta. 1 hit.
PROSITE	PS50975. ATP_GRASP. 1 hit. PS01217. SUCCINYL_COA_LIG_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUCC_RICTY

Accession

Primary (citable) accession number: Q68WU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program