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Protein

NAD kinase

Gene

nadK

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44Proton acceptorUniRule annotation1
Binding sitei49NADUniRule annotation1
Binding sitei144NADUniRule annotation1
Binding sitei152NAD; via carbonyl oxygenUniRule annotation1
Binding sitei216NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 45NADUniRule annotation2
Nucleotide bindingi114 – 115NADUniRule annotation2
Nucleotide bindingi155 – 160NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciRTYP257363:G1G0L-434-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:RT0427
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000000604 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002296841 – 255NAD kinaseAdd BLAST255

Proteomic databases

PRIDEiQ68WT8

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0427

Structurei

3D structure databases

ProteinModelPortaliQ68WT8
SMRiQ68WT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000139847
KOiK00858
OMAiNGIERMS
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 1 hit
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q68WT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTNKIALIY NKNSKHLAII EEIKKLFNYC KIEDAEVIII IGGDGELLHN
60 70 80 90 100
IHRYMHLNIP FYGLNLGSLG FLMNPLDTKK LLQNIYESTV SVLNPLLMQA
110 120 130 140 150
EDTNGQIYKA LAINEVSIFR KTNQAAKFRI DINGVERMSE LVADGALVAT
160 170 180 190 200
PAGSSAYNLS AGGPILPLAS NMLCLTPICS FRPRRWHGAL LLSSATIKFE
210 220 230 240 250
ILNITKRPVN ATADFQEFNN ITRVTVKSTK DQHIKLLFNK NHTLEDRIIK

EQFGE
Length:255
Mass (Da):28,597
Last modified:October 11, 2004 - v1
Checksum:i496C7ED4D02A7DD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA Translation: AAU03904.1
RefSeqiWP_011190888.1, NC_006142.1

Genome annotation databases

EnsemblBacteriaiAAU03904; AAU03904; RT0427
KEGGirty:RT0427

Similar proteinsi

Entry informationi

Entry nameiNADK_RICTY
AccessioniPrimary (citable) accession number: Q68WT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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